Binding of Gbeta/gamma to GIRK/Kir3 channels

Stable Identifier
R-HSA-1013012
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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Binding of Gbeta/gamma to GIRK/Kir3 channels
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The release of G beta gamma from Gi/o enables binding of G beta gamma to GIRK/Kir3 K+ channels.
Literature References
PubMed ID Title Journal Year
20655490 GABAB-GIRK2-mediated signaling in Down syndrome

Cramer, NP, Best, TK, Stoffel, M, Siarey, RJ, Galdzicki, Z

Adv Pharmacol 2010
Participants
Input
Output
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as an event of
Catalyst Activity

G protein-coupled GABA receptor activity of GABBR1:GABBR2:GABA [plasma membrane]

Physical Entity
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
Activity
G protein-coupled GABA receptor activity (GO:0004965)
Orthologous Events
Binding of Gbeta/gamma to GIRK/Kir3 channels (Bos taurus)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Caenorhabditis elegans)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Canis familiaris)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Drosophila melanogaster)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Mus musculus)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Rattus norvegicus)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Sus scrofa)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Xenopus tropicalis)
Authored
Mahajan, SS  (2010-11-26)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2010-11-12)
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