Binding of Gbeta/gamma to GIRK/Kir3 channels

Stable Identifier
R-HSA-1013012
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Binding of Gbeta/gamma to GIRK/Kir3 channels
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The release of G beta gamma from Gi/o enables binding of G beta gamma to GIRK/Kir3 K+ channels.

Literature References
PubMed ID Title Journal Year
20655490 GABAB-GIRK2-mediated signaling in Down syndrome

Cramer, NP, Siarey, RJ, Stoffel, M, Galdzicki, Z, Best, TK

Adv Pharmacol 2010
Participants
Input
Output
Participates
as an event of
Catalyst Activity

G protein-coupled GABA receptor activity of GABBR1:GABBR2:GABA [plasma membrane]

Physical Entity
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
Activity
G protein-coupled GABA receptor activity (GO:0004965)
Orthologous Events
Binding of Gbeta/gamma to GIRK/Kir3 channels (Bos taurus)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Caenorhabditis elegans)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Canis familiaris)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Danio rerio)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Drosophila melanogaster)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Gallus gallus)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Mus musculus)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Rattus norvegicus)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Sus scrofa)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Xenopus tropicalis)
Authored
Mahajan, SS  (2010-11-26)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2010-11-12)
Cite Us!