Activation of GABAB receptors

Stable Identifier
R-HSA-991365
Type
Pathway
Species
Homo sapiens
Compartment
cytosol, extracellular region
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Activation of GABAB receptors
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GABA B receptors are metabotropic receptors that are functionally linked to C type G protein coupled receptors.? GABA B receptors are activated upon ligand binding. The GABA B1 subunit binds ligand and GABA B2 subunit modulates the activity of adenylate cyclase via the intracellular loop.? GABA B receptors show inhibitory activity via Galpha/G0 subunits via the inhibition of adenylate cyclase or via the activity of Gbeta/gamma subunits that mediate the inhibition of voltage gated Ca2+ channels.

Literature References
PubMed ID Title Journal Year
20655481 GABAB receptor coupling to G-proteins and ion channels

Padgett, CL, Slesinger, PA

Adv Pharmacol 2010
Participants
Events
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Orthologous Events
Activation of GABAB receptors (Bos taurus)
Activation of GABAB receptors (Caenorhabditis elegans)
Activation of GABAB receptors (Canis familiaris)
Activation of GABAB receptors (Danio rerio)
Activation of GABAB receptors (Dictyostelium discoideum)
Activation of GABAB receptors (Drosophila melanogaster)
Activation of GABAB receptors (Gallus gallus)
Activation of GABAB receptors (Mus musculus)
Activation of GABAB receptors (Rattus norvegicus)
Activation of GABAB receptors (Sus scrofa)
Activation of GABAB receptors (Xenopus tropicalis)
Authored
Mahajan, SS  (2010-11-08)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2010-11-03)