Reactome | TBX21 [nucleoplasm]

TBX21 [nucleoplasm]

Stable Identifier

R-HSA-9942502

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

T-box transcription factor TBX21, TBX21_HUMAN, T-BET

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UL17 TBX21

Gene Names

TBX21, TBET, TBLYM

Chain

chain:1-535

Reference Genes

BioGPS Gene:30009 TBX21

COSMIC - genes:TBX21 TBX21

CTD Gene:30009 TBX21

dbSNP Gene:30009 TBX21

ENSEMBL:ENSG00000073861 TBX21

HGNC:11599 TBX21

KEGG:hsa:30009 TBX21

Monarch:30009 TBX21

NCBI Gene:30009 TBX21

OMIM:604895 TBX21

UCSC:Q9UL17 TBX21

Reference Transcript

RefSeq:NM_013351.2 TBX21

Other Identifiers

11732538_at

16835313

220684_PM_at

220684_at

30009

3724863

3724864

3724865

3724866

3724867

3724868

3724869

3724870

3724871

3724872

3724873

3724874

3724875

8008029

82450_at

A_23_P141555

GE80261

GO:0000122

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001227

GO:0001228

GO:0001708

GO:0002296

GO:0002376

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0006355

GO:0006357

GO:0009615

GO:0010628

GO:0030154

GO:0030163

GO:0030217

GO:0032703

GO:0043025

GO:0043161

GO:0043565

GO:0045580

GO:0045892

GO:0045893

GO:0045944

GO:0048304

GO:0048870

GO:0050776

GO:0072676

GO:1990837

GO:2000320

GO:2000329

GO:2000552

GO:2000556

HMNXSV003029748

ILMN_1692714

PH_hs_0014075

TC17000613.hg

g7019548_3p_at

g7019548_3p_x_at

Participates

as an input of

as a component of

as an output of

STAT proteins and NFATC1 positively regulate expression of TBX21 during differentiation of T helper 1 cells (Th1 cells) (Homo sapiens)

This entity regulates

Positively

TBX21 positively regulates expression of Protein-tyrosine sulfotransferase 2 (TPST2) (Homo sapiens)

Cross References

RefSeq

NP_037483.1

ENSEMBL

ENSG00000073861, ENST00000177694, ENSP00000177694

OpenTargets

ENSG00000073861

GeneCards

TBX21

HPA

ENSG00000073861-TBX21

PRO

Q9UL17

Pharos - Targets

Q9UL17

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.576	6
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.576	4
UniProt:Q92793 CREBBP	4	CREBBP [nucleoplasm] (R-HSA-193545) CREBBP [cytosol] (R-HSA-9756493) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877)	0.524	4
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.499	5

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