STAT proteins and NFATC1 positively regulate expression of TBX21 during differentiation of T helper 1 cells (Th1 cells)

Stable Identifier
R-HSA-9942499
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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STAT proteins and NFATC1 positively regulate expression of TBX21 during differentiation of T helper 1 cells (Th1 cells)
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The initial phase of TBX21 expression in naive CD4+ T cells cells is activated by STAT1 dimers phosphorylated on serine-727 that result from IFNG signaling (inferred from mouse homologs in Lighvani et al. 2001, Afkarian et al. 2002, Maldonado et al. 2009) and NFATC1 that result from T cell receptor (TCR) signaling (inferred from mouse homologs in Zhong et al. 2025). A second phase of expression occurs after cessation of TCR signaling and is activated by IL12 acting via IL12RB2 and STAT4 (inferred from mouse cells in Schulz et al. 2009).
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-Y693-STAT4 dimer:p-STAT1 dimer:NFATC1:TBX21 gene [nucleoplasm] (Homo sapiens)
Active Unit
p-Y693-STAT4 dimer [nucleoplasm]
Regulator
p-STAT1:NFATC1:TBX21 gene [nucleoplasm] (Homo sapiens)
Active Unit
p-STAT1 homodimer [nucleoplasm]
p-S257-NFATC1 [nucleoplasm]
Inferred From
Stat proteins and Nfatc1 positively regulate expression of Tbx21 in CD+ naive T cells (Mus musculus)
Authored
May, B  (2025-03-17)
Reviewed
Barbutti, I  (2025-08-04)
Lord, GM  (2025-08-05)
Created
May, B  (2025-03-17)
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