TBX21 binds the Tumor necrosis factor (TNF) gene

Stable Identifier
R-HSA-9942910
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TBX21 binds the Tumor necrosis factor (TNF) gene
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In T helper 1 cells (Th1 cells), TBX21 binds the super enhancer of the tumor necrosis factor alpha (TNF-alpha, TNF) gene (Jenner et al. 2009, Henderson et al. 2021) and upregulates expression (Jenner et al. 2009).
Literature References
PubMed ID Title Journal Year
34531288 The Th1 cell regulatory circuitry is largely conserved between human and mouse

Henderson, S, Pullabhatla, V, Hertweck, A, de Rinaldis, E, Herrero, J, Lord, GM, Jenner, RG

Life Sci Alliance 2021
19805038 The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes

Jenner, RG, Townsend, MJ, Jackson, I, Sun, K, Bouwman, RD, Young, RA, Glimcher, LH, Lord, GM

Proc Natl Acad Sci U S A 2009
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Tbx21 binds the Tumor necrosis factor (Tnf) gene (Mus musculus)
Authored
May, B  (2025-03-19)
Reviewed
Barbutti, I  (2025-08-04)
Lord, GM  (2025-08-05)
Created
May, B  (2025-03-19)
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