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NR1D1 gene [nucleoplasm]
Stable Identifier
R-HSA-5641202
Type
DNA Sequence [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Heme signaling (Homo sapiens)
Expression of NR1D1 (REV-ERBA) (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1:heme:Corepressors:NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
RORA:Coactivator:NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
p-BMAL1:p-CLOCK,NPAS2:NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1 (REV-ERBA) binds heme, the NR1D1 gene, and recruits corepressors (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1:heme:Corepressors:NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
Circadian clock (Homo sapiens)
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes (Homo sapiens)
Phosphorylated BMAL1:CLOCK positively regulates expression of NR1D1 (REV-ERBA) (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the NR1D1 (REV-ERBA) gene (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters (Homo sapiens)
CLOCK acetylates BMAL1 on lysine-538 (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
p-T451,T461-CLOCK is phosphorylated on serines-440,441,446 (Homo sapiens)
p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression (Homo sapiens)
NR1D1 (REV-ERBA) binds heme, the NR1D1 gene, and recruits corepressors (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1:heme:Corepressors:NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
RORA,C and coactivators bind the NR1D1 (REV-ERBA) gene (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
RORA,C:Coactivator:NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
RORA,C positively regulate expression and NR1D1 negatively regulates expression of NR1D1 (REV-ERBA) (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1:heme:Corepressors:NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
RORA,C:Coactivator:NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex (Homo sapiens)
CSNK1D,E phosphorylates CLOCK in p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-538-BMAL:p-2T,3S-CLOCK:target gene (Homo sapiens)
p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-K538-BMAL1:p-3S,2T-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-K538-BMAL1:p-4S,2T-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-4S,2T-CLOCK:Target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-S,T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S-CRY:p-S-PER:CSNK1D,E binds p-S90,Ac-K538-BMAL1:p-2T,3S-CLOCK:target gene (Homo sapiens)
p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-K538-BMAL1:p-3S,2T-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-538-BMAL1:p-4S,2T-CLOCK dissociates from target gene (Homo sapiens)
Target gene of BMAL1:CLOCK [nucleoplasm] (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-K538-BMAL1:p-4S,2T-CLOCK:target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-4S,2T-CLOCK:Target gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-S,T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1 gene [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
ENSEMBL:ENSG00000126368 NR1D1
Gene Names
NR1D1, EAR1, HREV, THRAL
Participates
as a component of
p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
RORA,C:Coactivator:NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-S,T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] (Homo sapiens)
RORA:Coactivator:NR1D1 gene [nucleoplasm] (Homo sapiens)
p-BMAL1:p-CLOCK,NPAS2:NR1D1 gene [nucleoplasm] (Homo sapiens)
NR1D1:heme:Corepressors:NR1D1 gene [nucleoplasm] (Homo sapiens)
as an input of
RORA,C and coactivators bind the NR1D1 (REV-ERBA) gene (Homo sapiens)
RORA,C positively regulate expression and NR1D1 negatively regulates expression of NR1D1 (REV-ERBA) (Homo sapiens)
Phosphorylated BMAL1:CLOCK positively regulates expression of NR1D1 (REV-ERBA) (Homo sapiens)
NR1D1 (REV-ERBA) binds heme, the NR1D1 gene, and recruits corepressors (Homo sapiens)
p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the NR1D1 (REV-ERBA) gene (Homo sapiens)
Expression of NR1D1 (REV-ERBA) (Homo sapiens)
as a member of
Target gene of BMAL1:CLOCK [nucleoplasm] (Homo sapiens)
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