p-S97-Bmal1:p-T451,T461-Clock and coactivators bind the Nr1d1 (Rev-erba) gene

Stable Identifier
R-MMU-9926618
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-S97-Bmal1:p-T451,T461-Clock and coactivators bind the Nr1d1 (Rev-erba) gene
Phosphorylated Bmal1:Clock heterodimers bind at least two (Ripperger 2006) and possibly seven (Koike et al. 2012) E-boxes in the promoter of the Nr1d1 (Rev-erba) gene (also inferred from the rat homolog in Triqueneaux et al. 2004). The Bmal1:Clock heterodimers recruit the histone methyltransferase Kmt2a (inferred from Bmal1:Clock at the Per2 promoter in Katada and Sassone-Corsi 2010) and the histone acetyltransferase Crebbp (Koike et al. 2012).
Literature References
PubMed ID Title Journal Year
22936566 Transcriptional architecture and chromatin landscape of the core circadian clock in mammals

Koike, N, Yoo, SH, Huang, HC, Kumar, V, Lee, C, Kim, TK, Takahashi, JS

Science 2012
16687287 Mapping of binding regions for the circadian regulators BMAL1 and CLOCK within the mouse Rev-erbalpha gene

Ripperger, JA

Chronobiol Int 2006
Participants
Input
Output
Orthologous Events
p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the NR1D1 (REV-ERBA) gene (Homo sapiens)
Authored
May, B  (2024-11-01)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-11-01)
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