Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy

Stable Identifier
R-HSA-9857377
Type
Pathway
Species
Homo sapiens
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5/5
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Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
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MITF regulates biogenesis of organelles such as the lysosome and endosomes through its regulation of components of the V-ATPase that is required for organelle acidification and function (Zhang et al, 2015; Ploper et al, 2015a; reviewed in Ploper et al, 2015b). MITF-dependent targets also contribute to autophagy when cells are stressed for nutrients (Möller et al, 2019). MITF additionally controls expression of the lysosome-resident acid ceramidase ASAH1 that has roles in sphingolipid metabolism and cellular proliferation in melanoma (Leclerc et al, 2019; Realini et al, 2016).
Literature References
PubMed ID Title Journal Year
30705290 MITF has a central role in regulating starvation-induced autophagy in melanoma

Möller, K, Sigurbjornsdottir, S, Arnthorsson, AO, Pogenberg, V, Dilshat, R, Fock, V, Brynjolfsdottir, SH, Bindesboll, C, Bessadottir, M, Ogmundsdottir, HM, Simonsen, A, Larue, L, Wilmanns, M, Thorsson, V, Steingrímsson, E, Ogmundsdóttir, MH

Sci Rep 2019
26092939 Mitf is a master regulator of the v-ATPase, forming a control module for cellular homeostasis with v-ATPase and TORC1

Zhang, T, Zhou, Q, Ogmundsdottir, MH, Möller, K, Siddaway, R, Larue, L, Hsing, M, Kong, SW, Goding, CR, Palsson, A, Steingrímsson, E, Pignoni, F

J Cell Sci 2015
26003288 The MITF family of transcription factors: Role in endolysosomal biogenesis, Wnt signaling, and oncogenesis

Ploper, D, De Robertis, EM

Pharmacol Res 2015
26553872 Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION

Realini, N, Palese, F, Pizzirani, D, Pontis, S, Basit, A, Bach, A, Ganesan, A, Piomelli, D

J Biol Chem 2016
30254208 Lysosomal acid ceramidase ASAH1 controls the transition between invasive and proliferative phenotype in melanoma cells

Leclerc, J, Garandeau, D, Pandiani, C, Gaudel, C, Bille, K, Nottet, N, Garcia, V, Colosetti, P, Pagnotta, S, Bahadoran, P, Tondeur, G, Mograbi, B, Dalle, S, Caramel, J, Levade, T, Ballotti, R, Andrieu-Abadie, N, Bertolotto, C

Oncogene 2019
25605940 MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells

Ploper, D, Taelman, VF, Robert, L, Perez, BS, Titz, B, Chen, HW, Graeber, TG, von Euw, E, Ribas, A, De Robertis, EM

Proc Natl Acad Sci U S A 2015
Participants
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as an event of
Authored
Rothfels, K  (2023-12-21)
Reviewed
Arnheiter, H  (2024-02-26)
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-01-04)
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