MITF-M dimer binds the ASAH1 gene

Stable Identifier
R-HSA-9859098
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M dimer binds the ASAH1 gene
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ASAH1 encodes a lysosomal ceramidase that cleaves sphingolipids into sphingosine and fatty acids. Melanocytes and proliferating melanoma cells have higher levels of ASAH1 than other skin cells and non-melanoma cancer cells, and corresponding lower levels of ceramide (Realini et al, 2016). Ectopic expression of ASAH1 rescues the cell cycle defect associated with MITF depletion in melanoma cells, consistent with a role for MITF and ASAH1 in promoting proliferation (Realini et al, 2016; LeClerc et al, 2019). ASAH1 is a direct target of MITF as assessed by ChIP-seq and reporter assay, and MITF binding at the promoter overlaps with regions of H3K27ac and H3K4me3, associated with active transcription (LeClerc et al, 2019).
Literature References
PubMed ID Title Journal Year
26553872 Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION

Piomelli, D, Bach, A, Palese, F, Basit, A, Realini, N, Pontis, S, Pizzirani, D, Ganesan, A

J Biol Chem 2016
30254208 Lysosomal acid ceramidase ASAH1 controls the transition between invasive and proliferative phenotype in melanoma cells

Bertolotto, C, Pagnotta, S, Gaudel, C, Andrieu-Abadie, N, Tondeur, G, Caramel, J, Garandeau, D, Mograbi, B, Dalle, S, Bille, K, Pandiani, C, Ballotti, R, Leclerc, J, Nottet, N, Colosetti, P, Levade, T, Bahadoran, P, Garcia, V

Oncogene 2019
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Output
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Authored
Rothfels, K  (2023-12-21)
Reviewed
de la Serna, IL  (2024-05-21)
Arnheiter, H  (2024-02-26)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2024-01-15)
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