MITF-M-dependent ASAH1 expression

Stable Identifier
R-HSA-9859104
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, lysosomal lumen
ReviewStatus
5/5
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MITF-M-dependent ASAH1 expression
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ASAH1 is a ceramidase that cleaves ceramides into sphingosine and free fatty acids. ASAH1 expression is high in melanocytes and melanoma cells and has been implicated in regulation of MITF-M-dependent cellular proliferation (LeClerc et al, 2019; Realini et al, 2016; reviewed in Goding and Arnheiter, 2019). Ectopic expression of ASAH1 rescues the proliferation defect of MITF-depleted melanoma cells, while depletion of ASAH1 decreases cellular proliferation rates and increases cell invasiveness, consistent with the phenotypes seen with MITF (LeClerc et al, 2019).
Literature References
PubMed ID Title Journal Year
31123060 MITF-the first 25 years

Arnheiter, H, Goding, CR

Genes Dev 2019
26553872 Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION

Piomelli, D, Bach, A, Palese, F, Basit, A, Realini, N, Pontis, S, Pizzirani, D, Ganesan, A

J Biol Chem 2016
30254208 Lysosomal acid ceramidase ASAH1 controls the transition between invasive and proliferative phenotype in melanoma cells

Bertolotto, C, Pagnotta, S, Gaudel, C, Andrieu-Abadie, N, Tondeur, G, Caramel, J, Garandeau, D, Mograbi, B, Dalle, S, Bille, K, Pandiani, C, Ballotti, R, Leclerc, J, Nottet, N, Colosetti, P, Levade, T, Bahadoran, P, Garcia, V

Oncogene 2019
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MITF-M dimer:ASAH1 gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF-M dimer [nucleoplasm]
Authored
Rothfels, K  (2023-12-21)
Reviewed
de la Serna, IL  (2024-05-21)
Arnheiter, H  (2024-02-26)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2024-01-15)
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