Positive Regulation of CDH1 Gene Transcription

Stable Identifier
R-HSA-9764790
Type
Pathway
Species
Homo sapiens
ReviewStatus
3/5
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Positive Regulation of CDH1 Gene Transcription
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Numerous transcription factors have been identified as direct positive regulators of transcription of CDH1 gene (also known as E-cadherin, epithelial cadherin, Cadherin-1, CADH1, or uvomorulin). Only those transcription factors reported to directly stimulate CDH1 gene transcription in at least two studies have been annotated in this pathway. These include ARID1A (Yan et al. 2014; Baldi et al. 2022), FOXA2 (Zhang et al. 2015; Bow et al. 2020; Liu et al. 2021), FOXJ2 (Martin de Lara et al. 2008; Zhang et al. 2018), KLF4 (Yori et al. 2010; Bjerke et al. 2011; Koopmansch et al. 2013; Lee et al. 2014; Lin et al. 2018), KLF9 (Zhong et al. 2018; Bai et al. 2021), RB1 (Batsche et al. 1998; Decary et al. 2002; Arima et al. 2008), SP1 (Mauro et al. 2007; Jin and Datta 2014; Zhang et al. 2022), and TFAP2A (Faraldo et al. 1997; Batsche et al. 1998; Decary et al. 2002; Schwartz et al. 2007; Arima et al. 2008).

Transcription factors implicated in direct upregulation of CDH1 gene transcription by a single study are not shown in the pathway diagram. These include CREB1 (Mauro et al. 2007), GATA3 (Yan et al. 2010), GRHL2 (Werth et al. 2010), GRHL3 (Alotaibi et al. 2015), MITF (Mansky et al. 2002), MSX2 (Lin et al. 2018), NACC1 (Faiola et al. 2017), PDX1 (Marty Santos et al. 2016), RUNX2 (Li et al. 2018), and TFAP2C (Wang et al. 2020).

Literature References
PubMed ID Title Journal Year
36420658 ARID1A downregulation promotes cell proliferation and migration of colon cancer via VIM activation and CDH1 suppression

Baldi, S, Zhang, Q, Zhang, Z, Safi, M, Khamgan, H, Wu, H, Zhang, M, Qian, Y, Gao, Y, Shopit, A, Al-Danakh, A, Alradhi, M, Al-Nusaif, M, Zuo, Y

J Cell Mol Med 2022
23376074 Interplay between KLF4 and ZEB2/SIP1 in the regulation of E-cadherin expression

Koopmansch, B, Berx, G, Foidart, JM, Gilles, C, Winkler, R

Biochem Biophys Res Commun 2013
9632747 RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2

Batsché, E, Muchardt, C, Behrens, J, Hurst, HC, Crémisi, C

Mol Cell Biol 1998
25138274 Nuclear factor I-C (NFIC) regulates dentin sialophosphoprotein (DSPP) and E-cadherin via control of Krüppel-like factor 4 (KLF4) during dentinogenesis

Lee, HK, Lee, DS, Park, SJ, Cho, KH, Bae, HS, Park, JC

J Biol Chem 2014
24293408 Reduced expression of the chromatin remodeling gene ARID1A enhances gastric cancer cell migration and invasion via downregulation of E-cadherin transcription

Yan, HB, Wang, XF, Zhang, Q, Tang, ZQ, Jiang, YH, Fan, HZ, Sun, YH, Yang, PY, Liu, F

Carcinogenesis 2014
34727382 Transcriptional repression of E-cadherin in nickel-exposed lung epithelial cells mediated by loss of Sp1 binding at the promoter

Zhang, X, Tanwar, VS, Jose, CC, Lee, HW, Cuddapah, S

Mol Carcinog 2022
25779673 FOXA2 attenuates the epithelial to mesenchymal transition by regulating the transcription of E-cadherin and ZEB2 in human breast cancer

Zhang, Z, Yang, C, Gao, W, Chen, T, Qian, T, Hu, J, Tan, Y

Cancer Lett 2015
28781078 NAC1 Regulates Somatic Cell Reprogramming by Controlling Zeb1 and E-cadherin Expression

Faiola, F, Yin, N, Fidalgo, M, Huang, X, Saunders, A, Ding, J, Guallar, D, Dang, B, Wang, J

Stem Cell Reports 2017
34354866 Krüppel-like factor 9 upregulates E-cadherin transcription and represses breast cancer invasion and metastasis

Bai, X, Jiang, X, Liu, Y, Wang, Y, Jiang, X, Song, G, Qiu, H, Zhang, Q

Am J Cancer Res 2021
9328434 Analysis of the E-cadherin and P-cadherin promoters in murine keratinocyte cell lines from different stages of mouse skin carcinogenesis

Faraldo, ML, Rodrigo, I, Behrens, J, Birchmeier, W, Cano, A

Mol Carcinog 1997
33718155 FOXA2-Interacting FOXP2 Prevents Epithelial-Mesenchymal Transition of Breast Cancer Cells by Stimulating E-Cadherin and PHF2 Transcription

Liu, Y, Chen, T, Guo, M, Li, Y, Zhang, Q, Tan, G, Yu, L, Tan, Y

Front Oncol 2021
30097516 The homeobox transcription factor MSX2 partially mediates the effects of bone morphogenetic protein 4 (BMP4) on somatic cell reprogramming

Lin, L, Liang, L, Yang, X, Sun, H, Li, Y, Pei, D, Zheng, H

J Biol Chem 2018
31957176 Silencing of FOXA2 decreases E-cadherin expression and is associated with lymph node metastasis in oral cancer

Bow, YD, Wang, YY, Chen, YK, Su, CW, Hsu, CW, Xiao, LY, Yuan, SS, Li, RN

Oral Dis 2020
21746878 Cooperative transcriptional activation by Klf4, Meis2, and Pbx1

Bjerke, GA, Hyman-Walsh, C, Wotton, D

Mol Cell Biol 2011
20356845 Kruppel-like factor 4 inhibits epithelial-to-mesenchymal transition through regulation of E-cadherin gene expression

Yori, JL, Johnson, E, Zhou, G, Jain, MK, Keri, RA

J Biol Chem 2010
17224907 Loss of AP-2alpha results in deregulation of E-cadherin and MMP-9 and an increase in tumorigenicity of colon cancer cells in vivo

Schwartz, B, Melnikova, VO, Tellez, C, Mourad-Zeidan, A, Blehm, K, Zhao, YJ, McCarty, M, Adam, L, Bar-Eli, M

Oncogene 2007
25483064 Oncogenic STRAP functions as a novel negative regulator of E-cadherin and p21(Cip1) by modulating the transcription factor Sp1

Jin, L, Datta, PK

Cell Cycle 2014
26657766 Pdx1 regulates pancreas tubulogenesis and E-cadherin expression

Marty-Santos, L, Cleaver, O

Development 2016
30542730 Expression of KLF9 in pancreatic cancer and its effects on the invasion, migration, apoptosis, cell cycle distribution, and proliferation of pancreatic cancer cell lines

Zhong, Z, Zhou, F, Wang, D, Wu, M, Zhou, W, Zou, Y, Li, J, Wu, L, Yin, X

Oncol Rep 2018
20189993 GATA3 inhibits breast cancer metastasis through the reversal of epithelial-mesenchymal transition

Yan, W, Cao, QJ, Arenas, RB, Bentley, B, Shao, R

J Biol Chem 2010
29416798 RUNX2 promotes epithelial differentiation of ADSCs and burn wound healing via targeting E-cadherin

Li, Q, Zhao, H, Xia, S, Wei, H, Chen, F, Jin, P

Oncotarget 2018
18726704 Biological effects of FoxJ2 over-expression

Martín-de-Lara, F, Sánchez-Aparicio, P, Arias de la Fuente, C, Rey-Campos, J

Transgenic Res 2008
11818451 The microphthalmia transcription factor (MITF) contains two N-terminal domains required for transactivation of osteoclast target promoters and rescue of mi mutant osteoclasts

Mansky, KC, Marfatia, K, Purdom, GH, Luchin, A, Hume, DA, Ostrowski, MC

J Leukoc Biol 2002
30206221 ARHGAP9 suppresses the migration and invasion of hepatocellular carcinoma cells through up-regulating FOXJ2/E-cadherin

Zhang, H, Zhang, H, Tang, QF, Sun, MY, Zhang, CY, Zhu, JY, Shen, YL, Zhao, B, Shao, ZY, Zhang, LJ

Cell Death Dis 2018
12391156 The retinoblastoma protein binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2

Decary, S, Decesse, JT, Ogryzko, V, Reed, JC, Naguibneva, I, Harel-Bellan, A, Cremisi, CE

Mol Cell Biol 2002
18593909 Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition

Arima, Y, Inoue, Y, Shibata, T, Hayashi, H, Nagano, O, Saya, H, Taya, Y

Cancer Res 2008
25652130 Enhancer cooperativity as a novel mechanism underlying the transcriptional regulation of E-cadherin during mesenchymal to epithelial transition

Alotaibi, H, Basilicata, MF, Shehwana, H, Kosowan, T, Schreck, I, Braeutigam, C, Konu, O, Brabletz, T, Stemmler, MP

Biochim Biophys Acta 2015
17409452 Evidences that leptin up-regulates E-cadherin expression in breast cancer: effects on tumor growth and progression

Mauro, L, Catalano, S, Bossi, G, Pellegrino, M, Barone, I, Morales, S, Giordano, C, Bartella, V, Casaburi, I, Andó, S

Cancer Res 2007
32587258 TFAP2C facilitates somatic cell reprogramming by inhibiting c-Myc-dependent apoptosis and promoting mesenchymal-to-epithelial transition

Wang, Y, Chen, S, Jiang, Q, Deng, J, Cheng, F, Lin, Y, Cheng, L, Ye, Y, Chen, X, Yao, Y, Zhang, X, Shi, G, Dai, L, Su, X, Peng, Y, Deng, H

Cell Death Dis 2020
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Orlic-Milacic, M  (2022-02-14)
Created
Orlic-Milacic, M  (2022-02-14)
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