FOXA2 stimulates CDH1 gene transcription

Stable Identifier
R-HSA-9765372
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
3/5
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FOXA2 stimulates CDH1 gene transcription
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FOXA2 directly stimulates transcription of the CDH1 gene (Zhang et al. 2015, Bow et al. 2020). In cancer, FOXA2-mediated stimulation of CDH1 gene expression is suggested to inhibit epithelial-to-mesenchymal transition (EMT) and invasiveness (Zhang et al. 2015, Bow et al. 2020). FOXA2 may stimulate the CDH1 gene expression together with its interaction partner FOXP2 (Liu et al. 2021), whose protein expression level has been reported to correlate with CDH1 protein levels by immunohistochemistry (Yan et al. 2015).
Literature References
PubMed ID Title Journal Year
25779673 FOXA2 attenuates the epithelial to mesenchymal transition by regulating the transcription of E-cadherin and ZEB2 in human breast cancer

Zhang, Z, Yang, C, Gao, W, Chen, T, Qian, T, Hu, J, Tan, Y

Cancer Lett 2015
31957176 Silencing of FOXA2 decreases E-cadherin expression and is associated with lymph node metastasis in oral cancer

Bow, YD, Wang, YY, Chen, YK, Su, CW, Hsu, CW, Xiao, LY, Yuan, SS, Li, RN

Oral Dis 2020
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
FOXA2:CDH1 gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXA2 [nucleoplasm]
Regulator
FOXP2 [nucleoplasm] (Homo sapiens)
Authored
Orlic-Milacic, M  (2022-02-15)
Created
Orlic-Milacic, M  (2022-02-15)
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