KLF9 stimulates CDH1 gene transcription

Stable Identifier
R-HSA-9764863
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
3/5
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KLF9 stimulates CDH1 gene transcription
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The transcription factor Kruppel-like factor 9 (KLF9) positively regulates CDH1 gene transcription (Zhong et al. 2018; Bai et al. 2021), acting as a direct transcriptional activator of the CDH1 gene (Bai et al. 2021). In both pancreatic (Zhong et al. 2018) and breast (Bai et al. 2021) cancer, decreased KLF9 levels are associated with reduced CDH1 expression and increased tumor invasiveness.
Literature References
PubMed ID Title Journal Year
30542730 Expression of KLF9 in pancreatic cancer and its effects on the invasion, migration, apoptosis, cell cycle distribution, and proliferation of pancreatic cancer cell lines

Zhong, Z, Zhou, F, Wang, D, Wu, M, Zhou, W, Zou, Y, Li, J, Wu, L, Yin, X

Oncol Rep 2018
34354866 Krüppel-like factor 9 upregulates E-cadherin transcription and represses breast cancer invasion and metastasis

Bai, X, Jiang, X, Liu, Y, Wang, Y, Jiang, X, Song, G, Qiu, H, Zhang, Q

Am J Cancer Res 2021
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
KLF9:CDH1 gene [nucleoplasm] (Homo sapiens)
Active Unit
KLF9 [nucleoplasm]
Authored
Orlic-Milacic, M  (2022-02-14)
Created
Orlic-Milacic, M  (2022-02-14)
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