KLF4 binds CDH1 gene promoter

Stable Identifier
R-HSA-9765326
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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KLF4 binds CDH1 gene promoter
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The transcription factor Kruppel-like factor 4 (KLF4) directly binds to the GC-rich/E-box region in the CDH1 gene promoter to activate CDH1 gene transcription (Yori et al. 2010, Koopmansch et al. 2013). The KLF4 binding site in the CDH1 gene promoter partially overlaps with the ZEB2 binding site. Binding of ZEB2, a transcriptional repressor of the CDH1 gene, interferes with KLF4 binding (Koopmansch et al. 2013). Transcription factors PBX1 and MEIS2 may form a complex with KLF4 and facilitate KLF4 binding to the CDH1 gene promoter (Bjerke et al. 2011). Direct binding of KLF4 to the CDH1 gene promoter is evolutionarily conserved in mouse, where KLF4-mediated upregulation of CDH1 occurs downstream of the nuclear factor I-C (NFIC) during dentogenesis (Lee et al. 2014). KLF4 may bind to the CDH1 gene promoter cooperatively with the homeobox transcription factor MSX2 (Lin et al. 2018). Depending on the cellular context, KLF4 binding to the CDH1 gene promoter may have a repressive effect on the CDH1 gene transcription (Lai et al. 2012).
Literature References
PubMed ID Title Journal Year
22854048 Krüppel-like factor 4 is involved in cell scattering induced by hepatocyte growth factor

Lai, JK, Wu, HC, Shen, YC, Hsieh, HY, Yang, SY, Chang, CC

J Cell Sci 2012
20356845 Kruppel-like factor 4 inhibits epithelial-to-mesenchymal transition through regulation of E-cadherin gene expression

Yori, JL, Johnson, E, Zhou, G, Jain, MK, Keri, RA

J Biol Chem 2010
23376074 Interplay between KLF4 and ZEB2/SIP1 in the regulation of E-cadherin expression

Koopmansch, B, Berx, G, Foidart, JM, Gilles, C, Winkler, R

Biochem Biophys Res Commun 2013
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
ZEB2:CDH1 gene [nucleoplasm] (Homo sapiens)
Active Unit
ZEB2 [nucleoplasm]
Authored
Orlic-Milacic, M  (2022-02-15)
Created
Orlic-Milacic, M  (2022-02-15)
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