F-box proteins were first characterized as components of SCF ubiquitin-ligase complexes (named after their main components, SkpI, Cullin, and an F-box protein), in which they bind substrates for ubiquitin-mediated proteolysis. The F-box motif links the F-box protein to other components of the SCF complex by binding the core SCF component SkpI.
Guardavaccaro, D, Chiaur, DS, Vidal, M, Pagano, M, Parks, W, Cenciarelli, C
Bennett, EJ, Gygi, SP, Rush, J, Harper, JW
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