F-box protein

Stable Identifier
R-HSA-976085
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Synonyms
substrate recognition component of a SCF E3 ligase complex
Locations in the PathwayBrowser
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Summation

F-box proteins were first characterized as components of SCF ubiquitin-ligase complexes (named after their main components, SkpI, Cullin, and an F-box protein), in which they bind substrates for ubiquitin-mediated proteolysis. The F-box motif links the F-box protein to other components of the SCF complex by binding the core SCF component SkpI.

Literature References
PubMed ID Title Journal Year
21145461 Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics

Bennett, EJ, Rush, J, Gygi, SP, Harper, JW

Cell 2010
10531035 Identification of a family of human F-box proteins

Cenciarelli, C, Chiaur, DS, Guardavaccaro, D, Parks, W, Vidal, M, Pagano, M

Curr. Biol. 1999
Participants
members
Participant Of
hasComponent
Inferred To
Ghost homologue of F-box protein [cytosol] (Plasmodium falciparum)
F-box protein [cytosol] (Arabidopsis thaliana)
F-box protein [cytosol] (Bos taurus)
F-box protein [cytosol] (Caenorhabditis elegans)
F-box protein [cytosol] (Canis familiaris)
F-box protein [cytosol] (Danio rerio)
F-box protein [cytosol] (Dictyostelium discoideum)
F-box protein [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Gallus gallus)
F-box protein [cytosol] (Mus musculus)
F-box protein [cytosol] (Oryza sativa)
F-box protein [cytosol] (Rattus norvegicus)
F-box protein [cytosol] (Saccharomyces cerevisiae)
F-box protein [cytosol] (Schizosaccharomyces pombe)
F-box protein [cytosol] (Sus scrofa)
F-box protein [cytosol] (Taeniopygia guttata)
F-box protein [cytosol] (Xenopus tropicalis)