F-box proteins were first characterized as components of SCF ubiquitin-ligase complexes (named after their main components, SkpI, Cullin, and an F-box protein), in which they bind substrates for ubiquitin-mediated proteolysis. The F-box motif links the F-box protein to other components of the SCF complex by binding the core SCF component SkpI.
Bennett, EJ, Rush, J, Gygi, SP, Harper, JW
Cenciarelli, C, Chiaur, DS, Guardavaccaro, D, Parks, W, Vidal, M, Pagano, M
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