Reactome | FBXO27 [cytosol]

FBXO27 [cytosol]

Stable Identifier

R-HSA-976039

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

F-box only protein 27, FBX27_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO27 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO27 [cytosol] (Homo sapiens)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO27 [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO27 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO27 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO27 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO27 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO27 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO27 [cytosol] (Homo sapiens)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO27 [cytosol] (Homo sapiens)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO27 [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO27 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO27 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8NI29 FBXO27

Gene Names

FBXO27, FBG5, FBX27

Chain

chain:1-283

Reference Genes

BioGPS Gene:126433 FBXO27

COSMIC (genes):FBXO27 FBXO27

CTD Gene:126433 FBXO27

dbSNP Gene:126433 FBXO27

ENSEMBL:ENSG00000161243 FBXO27

HGNC:18753 FBXO27

KEGG Gene (Homo sapiens):126433 FBXO27

Monarch:126433 FBXO27

NCBI Gene:126433 FBXO27

OMIM:609099 FBXO27

UCSC:Q8NI29 FBXO27

Reference Transcript

RefSeq:NM_178820.4 FBXO27

Other Identifiers

0003290008

11734106_x_at

11750774_x_at

126433

16872166

235169_at

3861836

3861837

3861838

3861839

3861840

3861841

3861842

3861844

3861846

3861847

3861848

46800

62242

67668_at

8036689

A0A384MR61

A_24_P113264

AAH14527

AAH30060

AAM27918

ADO22561

AF436061

BC014527

BC030060

CCDS12527

CH471126

EAW56856

ENSG00000161243

ENSP00000292853

ENSP00000437662

ENST00000292853

ENST00000292853.8

ENST00000509137

ENST00000509137.6

EntrezGene:126433

EntrezGene:FBXO27

FBXO27

FBXO27-201

FBXO27-202

GE84622

GO:0000209

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0006464

GO:0006516

GO:0006950

GO:0008150

GO:0009056

GO:0019005

GO:0030433

GO:0031146

GO:0032991

GO:0043687

GO:0061630

GQ901044

HGNC:18753

HPA046800

HPA062242

Hs.187461.0.A1_3p_at

ILMN_1721360

ILMN_1783528

IPR001810

IPR007397

IPR008979

IPR036047

IPR039752

M0QYQ6

M0R1C3

MIM:609099

NM_178820

NP_849142

PF00646

PF04300

PH_hs_0010957

SM00256

SM01198

TC19001511.hg

UPI0000073006

XM_017026290

XP_016881779

Participant Of

hasMember

F-box protein [cytosol]

hasCandidate

E3 ligases in proteasomal degradation [cytosol]

Inferred To

FBXO27 [cytosol] (Bos taurus)

FBXO27 [cytosol] (Caenorhabditis elegans)

FBXO27 [cytosol] (Canis familiaris)

FBXO27 [cytosol] (Danio rerio)

FBXO27 [cytosol] (Rattus norvegicus)

FBXO27 [cytosol] (Sus scrofa)

Fbxo27 [cytosol] (Mus musculus)

Cross References

RefSeq

NP_849142.1

OpenTargets

ENSG00000161243

GeneCards

Q8NI29

HPA

ENSG00000161243-FBXO27

Ensembl

ENSG00000161243, ENSP00000437662, ENST00000292853, ENSP00000292853, ENST00000509137

PRO

Q8NI29

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.556	3

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