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FBXL13 [cytosol]
Stable Identifier
R-HSA-8862616
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
F-box/LRR-repeat protein 13, FXL13_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL13 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
24035498
Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover
Bennett, EJ
,
Lim, HJ
,
Shi, Y
,
Tan, MK
,
Harper, JW
Mol. Cell
2013
External Reference Information
External Reference
UniProt:Q8NEE6 FBXL13
Gene Names
FBXL13, DRC6, FBL13
Chain
chain:1-735
Reference Genes
BioGPS Gene:222235 FBXL13
COSMIC (genes):FBXL13 FBXL13
CTD Gene:222235 FBXL13
dbSNP Gene:222235 FBXL13
ENSEMBL:ENSG00000161040 FBXL13
HGNC:21658 FBXL13
KEGG:hsa:222235 FBXL13
Monarch:222235 FBXL13
NCBI Gene:222235 FBXL13
OMIM:609080 FBXL13
UCSC:Q8NEE6 FBXL13
Reference Transcript
RefSeq:XM_017011853.1 FBXL13
RefSeq:XM_011515930.2 FBXL13
RefSeq:XM_005250209.2 FBXL13
RefSeq:NM_145032.3 FBXL13
RefSeq:NM_001111038.1 FBXL13
RefSeq:NM_001287150.1 FBXL13
Other Identifiers
11737032_x_at
11740804_a_at
1553798_PM_a_at
1553798_a_at
17061156
222235
3065404
3065406
3065408
3065409
3065410
3065411
3065412
3065413
3065417
3065418
3065421
3065425
3065426
3065429
3065430
3065431
3065432
3065433
3065440
3065442
3065444
3065447
3065448
3065449
3065458
3065460
3065461
3065462
3065465
3065466
3065467
3065468
3065472
3065473
3065474
3882005
8141846
A_23_P379071
GE906249
GO:0005515
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005929
GO:0019005
GO:0030163
GO:0031146
GO:0031514
GO:0043226
HMNXSV003030131
HMNXSV003051791
Hs2.336025.1.S1_3p_a_at
ILMN_1791253
PH_hs_0016520
TC07001714.hg
Participates
as a member of
F-box protein [cytosol] (Homo sapiens)
Inferred To
Fbxl13 [cytosol]
(Mus musculus)
Homologues of FBXL13 [cytosol]
(Saccharomyces cerevisiae)
FBXL13 [cytosol]
(Bos taurus)
FBXL13 [cytosol]
(Gallus gallus)
FBXL13 [cytosol]
(Plasmodium falciparum)
FBXL13 [cytosol]
(Saccharomyces cerevisiae)
FBXL13 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001104508.1
,
XP_005250266.1
,
XP_016867342.1
,
NP_001274079.1
,
XP_011514232.1
,
NP_659469.3
ENSEMBL
ENST00000313221
,
ENSP00000321927
OpenTargets
ENSG00000161040
HPA
ENSG00000161040-FBXL13
PRO
Q8NEE6
Pharos - Targets
Q8NEE6
GlyGen
Q8NEE6
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