Reactome | FBXL12 [cytosol]

FBXL12

Stable Identifier

R-HSA-8862611

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

F-box/LRR-repeat protein 12, FXL12_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
      - Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)
      - Polyubiquitination of substrate (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)
        
        E3:Ub:substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)
      - Release of E3 from polyubiquitinated substrate (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)
      - Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)
        
        E3:Ub:substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXL12 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NXK8 FBXL12

Gene Names

FBXL12, FBL12

Chain

chain:1-326

Reference Genes

BioGPS Gene:54850 FBXL12

COSMIC (genes):FBXL12 FBXL12

CTD Gene:54850 FBXL12

dbSNP Gene:54850 FBXL12

ENSEMBL:ENSG00000127452 FBXL12

HGNC:13611 FBXL12

KEGG Gene (Homo sapiens):hsa:54850 FBXL12

Monarch:54850 FBXL12

NCBI Gene:54850 FBXL12

OMIM:609079 FBXL12

UCSC:Q9NXK8 FBXL12

Reference Transcript

Other Identifiers

0001660537

11754567_a_at

16868472

220127_s_at

2843

3849866

3849867

3849868

3849869

3849872

3849873

3849877

3849879

3849880

3849881

51676_at

53743_at

54850

8033813

89375_s_at

A_23_P78554

A_23_P78557

AAH01586

AK000195

AK027004

AK093760

BAA91002

BAB15622

BAG52760

BC001586

CCDS12218

CCDS82287

CH471106

EAW84051

ENSG00000127452

ENSP00000247977

ENSP00000467359

ENSP00000468369

ENST00000247977

ENST00000585379

ENST00000591009

EntrezGene:54850

FBXL12

FBXL12-201

FBXL12-202

FBXL12-211

g8923178_3p_a_at

GE55392

GO:0000151

GO:0000209

GO:0003674

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0006464

GO:0006511

GO:0008150

GO:0009056

GO:0016567

GO:0043687

HGNC:13611

HPA002843

ILMN_1693438

IPR001810

IPR032675

IPR036047

MIM:609079

NM_001316936

NM_001316937

NM_001316938

NM_001316939

NM_001316940

NM_001316941

NM_001316942

NM_017703

NP_001303865

NP_001303866

NP_001303867

NP_001303868

NP_001303869

NP_001303870

NP_001303871

NP_060173

PF12937

PH_hs_0001180

SM00256

TC19001154.hg

uc002mme.3

uc060tca.1

uc060tcb.1

UPI000006EBD0

UPI00000713C3

Participant Of

hasMember

F-box protein [cytosol]

Inferred To

FBXL12 [cytosol] (Bos taurus)

FBXL12 [cytosol] (Canis familiaris)

FBXL12 [cytosol] (Gallus gallus)

FBXL12 [cytosol] (Mus musculus)

FBXL12 [cytosol] (Rattus norvegicus)

FBXL12 [cytosol] (Sus scrofa)

FBXL12 [cytosol] (Xenopus tropicalis)

Homologues of FBXL12 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001303870.1, NP_001303868.1, NP_001303871.1, NP_060173.1, NP_001303867.1, NP_001303865.1, NP_001303866.1, NP_001303869.1

GeneCards

Q9NXK8

PRO

Q9NXK8

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.709	6
UniProt:P52286	2	SKP1 [nucleoplasm] (R-SCE-187538) SKP1 [cytosol] (R-SCE-174150)	0.556	3