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FBXL12
Stable Identifier
R-HSA-8862611
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
F-box/LRR-repeat protein 12, FXL12_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL12 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NXK8 FBXL12
Gene Names
FBXL12, FBL12
Chain
chain:1-326
Reference Genes
BioGPS Gene:54850 FBXL12
COSMIC (genes):FBXL12 FBXL12
CTD Gene:54850 FBXL12
dbSNP Gene:54850 FBXL12
ENSEMBL:ENSG00000127452 FBXL12
HGNC:13611 FBXL12
KEGG Gene (Homo sapiens):hsa:54850 FBXL12
Monarch:54850 FBXL12
NCBI Gene:54850 FBXL12
OMIM:609079 FBXL12
UCSC:Q9NXK8 FBXL12
Reference Transcript
RefSeq:NM_001316941.1 FBXL12
RefSeq:NM_001316940.1 FBXL12
RefSeq:NM_001316942.1 FBXL12
RefSeq:NM_017703.2 FBXL12
RefSeq:NM_001316937.1 FBXL12
RefSeq:NM_001316938.1 FBXL12
RefSeq:NM_001316936.1 FBXL12
RefSeq:NM_001316939.1 FBXL12
Other Identifiers
0001660537
11754567_a_at
16868472
220127_s_at
2843
3849866
3849867
3849868
3849869
3849872
3849873
3849877
3849879
3849880
3849881
51676_at
53743_at
54850
8033813
89375_s_at
A_23_P78554
A_23_P78557
CCDS12218
CCDS82287
ENSG00000127452
ENSP00000247977
ENSP00000467359
ENSP00000468369
ENST00000247977
ENST00000585379
ENST00000591009
EntrezGene:54850
FBXL12
FBXL12-201
FBXL12-202
FBXL12-211
g8923178_3p_a_at
GE55392
GO:0000151
GO:0000209
GO:0004842
GO:0005515
GO:0005737
GO:0005829
GO:0006511
GO:0016567
GO:0043687
HGNC:13611
HPA002843
Hs.12439
ILMN_1693438
NM_001316936
NM_001316937
NM_001316938
NM_001316939
NM_001316940
NM_001316941
NM_001316942
NM_017703
NP_001303865
NP_001303866
NP_001303867
NP_001303868
NP_001303869
NP_001303870
NP_001303871
NP_060173
PF12937
PH_hs_0001180
SM00256
TC19001154.hg
uc002mme.3
uc060tca.1
uc060tcb.1
UPI000006EBD0
UPI00000713C3
Participant Of
hasMember
F-box protein [cytosol]
Inferred To
FBXL12 [cytosol] (Bos taurus)
FBXL12 [cytosol] (Canis familiaris)
FBXL12 [cytosol] (Gallus gallus)
FBXL12 [cytosol] (Mus musculus)
FBXL12 [cytosol] (Rattus norvegicus)
FBXL12 [cytosol] (Sus scrofa)
FBXL12 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_001303869.1
,
NP_060173.1
,
NP_001303867.1
,
NP_001303870.1
,
NP_001303866.1
,
NP_001303865.1
,
NP_001303868.1
,
NP_001303871.1
GeneCards
Q9NXK8
PRO
Q9NXK8
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63208 SKP1
2
SKP1 [cytosol]
(R-HSA-174150)
SKP1 [nucleoplasm]
(R-HSA-187538)
0.709
8
UniProt:P52286
2
SKP1 [nucleoplasm]
(R-SCE-187538)
SKP1 [cytosol]
(R-SCE-174150)
0.556
3
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