AcK-NFE2L2-dependent TXNRD1 gene expression

Stable Identifier
R-HSA-9759364
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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AcK-NFE2L2-dependent TXNRD1 gene expression
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TXNRD1 gene expression is upregulated in response to oxidative and electrophilic stressors in a way that depends on the KEAP1-NFE2L2 pathway (Kwak et al, 2003; Kim et al, 2001; Malhotra et al, 2010; reviewed in Baird and Yamamoto, 2020).
Literature References
PubMed ID Title Journal Year
20460467 Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

Shyr, C, Srivastava, S, Wakabayashi, N, Wasserman, WW, Singh, A, Malhotra, D, Biswal, S, Happel, C, Portales-Casamar, E, Kensler, TW, Arenillas, D

Nucleic Acids Res 2010
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Yamamoto, M, Baird, L

Mol Cell Biol 2020
17234762 Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology

Park, YM, Ahn, JY, Ip, C, Kim, YJ, Zhang, Y, Liang, P

Cancer Res 2007
12506115 Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

Motohashi, H, Yamamoto, M, Wakabayashi, N, Itoh, K, Kwak, MK, Kensler, TW

J Biol Chem 2003
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
TXNRD1 gene:p-AcK-NFE2L2 [nucleoplasm] (Homo sapiens)
Active Unit
p-NFE2L2 [nucleoplasm]
Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2021-12-02)
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