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NFE2L2 regulating anti-oxidant/detoxification enzymes
Stable Identifier
R-HSA-9818027
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Homo sapiens)
General
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Subpathway representing cytoprotective genes regulated by NFE2L2 (NRF2). NFE2L2 is well-studied for its role in oxidative stress where it gets activated by ROS and then induces a plethora of gene expression regulation the oxidative damage. It induces genes/enzymes that regulate the phase 2 detoxification system (eg. GSTs and Glutathione system), ROS scavenging (SODs,PRDX1 ) and cytoprotection (HO1) by regulating inflammation and tissue damage (Tonelli et al, 2018; Shaw et al, 2020)
Participants
Events
NFE2L2 binds the GSR gene
(Homo sapiens)
NFE2L2-dependent GSR gene expression
(Homo sapiens)
NFE2L2 binds the PRDX1 promoter
(Homo sapiens)
NFE2L2-dependent PRDX1 gene expression
(Homo sapiens)
NFE2L2 binds the SRXN1 gene
(Homo sapiens)
NFE2L2-dependent SRXN1 gene expression
(Homo sapiens)
NFE2L2 and MAFK bind the HMOX1 gene
(Homo sapiens)
NFE2L2-dependent HMOX1 gene expression
(Homo sapiens)
AcK-NFE2L2 and MAFK bind NQO1 gene
(Homo sapiens)
AcK-NFE2L2- dependent NQO1 gene expression
(Homo sapiens)
AcK-NFE2L2 and MAFK bind the GSTA1 gene
(Homo sapiens)
AcK-NFE2L2-dependent GSTA1 gene expression
(Homo sapiens)
NFE2L2 binds the GSTA3 promoter
(Homo sapiens)
NFE2L2-dependent GSTA3 gene expression
(Homo sapiens)
AcK-NFE2L2 binds the GCLC gene
(Homo sapiens)
AcK-NFE2L2-dependent GCLC gene expression
(Homo sapiens)
AcK-NFE2L2 binds the GCLM gene
(Homo sapiens)
AcK-NFE2L2-dependent GCLM gene expression
(Homo sapiens)
AcK-NFE2L2 binds the TXNRD1 promoter
(Homo sapiens)
AcK-NFE2L2-dependent TXNRD1 gene expression
(Homo sapiens)
AcK-NFE2L2 binds the SOD3 gene
(Homo sapiens)
NFE2L2 dependent SOD3 expression
(Homo sapiens)
AcK-NFE2L2 binds the TXN gene
(Homo sapiens)
NFE2L2 dependent TXN expression
(Homo sapiens)
AcK-NFE2L2 and ATF4 bind the SLC7A11 gene
(Homo sapiens)
AcK-NFE2L2-dependent SLC7A11 expression
(Homo sapiens)
PRDX1 overoxidizes
(Homo sapiens)
SRXN1 reduces hyperoxidized PRDX1 dimer
(Homo sapiens)
Participates
as an event of
Nuclear events mediated by NFE2L2 (Homo sapiens)
Orthologous Events
NFE2L2 regulating anti-oxidant/detoxification enzymes (Bos taurus)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Caenorhabditis elegans)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Canis familiaris)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Danio rerio)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Dictyostelium discoideum)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Drosophila melanogaster)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Gallus gallus)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Mus musculus)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Rattus norvegicus)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Saccharomyces cerevisiae)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Schizosaccharomyces pombe)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Sus scrofa)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Xenopus tropicalis)
Authored
Tiwari, K (2022-10-10)
Created
Tiwari, K (2022-10-10)
© 2024
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