Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
N4BP1 [cytosol]
Stable Identifier
R-HSA-9757941
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
IKBKG:N4BP1 [cytosol] (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
IKBKG:N4BP1 [cytosol] (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
IKBKG:N4BP1 [cytosol] (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
IKBKG:N4BP1 [cytosol] (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
IKBKG:N4BP1 [cytosol] (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
IKBKG:N4BP1 [cytosol] (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
IKBKG:N4BP1 [cytosol] (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
IKBKG:N4BP1 [cytosol] (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
IKBKG:N4BP1 [cytosol] (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
IKBKG:N4BP1 [cytosol] (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
N4BP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75113 N4BP1
Gene Names
N4BP1, KIAA0615
Chain
chain:1-896
Reference Genes
BioGPS Gene:9683 N4BP1
COSMIC (genes):N4BP1 N4BP1
CTD Gene:9683 N4BP1
dbSNP Gene:9683 N4BP1
ENSEMBL:ENSG00000102921 N4BP1
HGNC:29850 N4BP1
KEGG:hsa:9683 N4BP1
Monarch:9683 N4BP1
NCBI Gene:9683 N4BP1
OMIM:619138 N4BP1
UCSC:O75113 N4BP1
Reference Transcript
RefSeq:NM_153029.3 N4BP1
Other Identifiers
11720843_at
11720844_at
16826367
204601_PM_at
204601_at
221867_PM_at
221867_at
32069_PM_at
32069_at
3690598
3690599
3690600
3690601
3690602
3690603
3690605
3690606
3690608
3690609
3690610
3690611
3690612
3690614
3690615
3690616
3690621
3690622
3690623
3690624
48612_PM_at
48612_at
4875898C_3p_s_at
8001317
9683
A_23_P432610
A_23_P66085
GE81951
GO:0001818
GO:0002376
GO:0003723
GO:0003729
GO:0003824
GO:0004518
GO:0004540
GO:0005515
GO:0005634
GO:0005730
GO:0005737
GO:0005829
GO:0016605
GO:0016787
GO:0031397
GO:0032435
GO:0034644
GO:0043130
GO:0043226
GO:0045071
GO:0045087
GO:0045088
GO:0098542
GO:0140098
HMNXSV003017092
HMNXSV003017349
Hs.296338.0.A1_3p_at
Hs.296338.0.A1_3p_x_at
ILMN_1706225
ILMN_2201966
PH_hs_0016111
PH_hs_0041169
TC16001098.hg
g7662203_3p_s_at
Participates
as an input of
CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)
N4BP1 binds IKBKG (Homo sapiens)
as a component of
IKBKG:N4BP1 [cytosol] (Homo sapiens)
Other forms of this molecule
N4BP1(1-490) [cytosol]
N4BP1(1-424) [cytosol]
Inferred To
CG13588 [cytosol]
(Drosophila melanogaster)
rde-8 [cytosol]
(Caenorhabditis elegans)
mps-1 [cytosol]
(Caenorhabditis elegans)
n4bp1 [cytosol]
(Danio rerio)
n4bp1 [cytosol]
(Xenopus tropicalis)
N4BP1 [cytosol]
(Bos taurus)
N4BP1 [cytosol]
(Caenorhabditis elegans)
N4BP1 [cytosol]
(Canis familiaris)
N4BP1 [cytosol]
(Gallus gallus)
N4BP1 [cytosol]
(Sus scrofa)
Homologues of N4BP1 [cytosol]
(Caenorhabditis elegans)
Homologues of N4BP1 [cytosol]
(Drosophila melanogaster)
N4bp1 [cytosol]
(Mus musculus)
N4bp1 [cytosol]
(Rattus norvegicus)
Regnase-1 [cytosol]
(Drosophila melanogaster)
nyn-3 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_694574.3
ENSEMBL
ENST00000262384
,
ENSP00000262384
OpenTargets
ENSG00000102921
HPA
ENSG00000102921-N4BP1
PRO
O75113
Pharos - Targets
O75113
GlyGen
O75113
PDB
6Q3V
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96J02 ITCH
2
Ub-C871-ITCH [cytosol]
(R-HSA-8864515)
ITCH [cytosol]
(R-HSA-975995)
0.591
3
UniProt:O15344 MID1
1
MID1 [cytosol]
(R-HSA-976027)
0.556
3
UniProt:Q99732 LITAF
0.556
3
UniProt:P46935
1
Nedd4 [cytosol]
(R-MMU-975992)
0.527
2
IntAct:EBI-4399559 UBIQ
0.524
2
UniProt:Q9QYP6 AZI2
0.499
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text