Reactome | IKBKG:N4BP1 [cytosol]

IKBKG:N4BP1 [cytosol]

Stable Identifier

R-HSA-9757950

Type

Complex

Species

Homo sapiens

Compartment

cytosol

Synonyms

NEMO:N4BP1

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-1 family signaling (Homo sapiens)
      - Interleukin-1 signaling (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        N4BP1 binds IKBKG (Homo sapiens)
        
        IKBKG:N4BP1 [cytosol] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        N4BP1 binds IKBKG (Homo sapiens)
        
        IKBKG:N4BP1 [cytosol] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        N4BP1 binds IKBKG (Homo sapiens)
        
        IKBKG:N4BP1 [cytosol] (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        N4BP1 binds IKBKG (Homo sapiens)
        
        IKBKG:N4BP1 [cytosol] (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        N4BP1 binds IKBKG (Homo sapiens)
        
        IKBKG:N4BP1 [cytosol] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        N4BP1 binds IKBKG (Homo sapiens)
        
        IKBKG:N4BP1 [cytosol] (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        N4BP1 binds IKBKG (Homo sapiens)
        
        IKBKG:N4BP1 [cytosol] (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        N4BP1 binds IKBKG (Homo sapiens)
        
        IKBKG:N4BP1 [cytosol] (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        N4BP1 binds IKBKG (Homo sapiens)
        
        IKBKG:N4BP1 [cytosol] (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        N4BP1 binds IKBKG (Homo sapiens)
        
        IKBKG:N4BP1 [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
33654074	N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization Shi, H, Sun, L, Wang, Y, Liu, A, Zhan, X, Li, X, Tang, M, Anderton, P, Hildebrand, S, Quan, J, Ludwig, S, Moresco, EMY, Beutler, B	Nat Commun	2021

Participants

components

Participates

as an output of

N4BP1 binds IKBKG (Homo sapiens)

Inferred To

IKBKG:N4BP1 [cytosol] (Bos taurus)

IKBKG:N4BP1 [cytosol] (Canis familiaris)

IKBKG:N4BP1 [cytosol] (Danio rerio)

IKBKG:N4BP1 [cytosol] (Drosophila melanogaster)

IKBKG:N4BP1 [cytosol] (Gallus gallus)

IKBKG:N4BP1 [cytosol] (Mus musculus)

IKBKG:N4BP1 [cytosol] (Rattus norvegicus)

IKBKG:N4BP1 [cytosol] (Sus scrofa)

IKBKG:N4BP1 [cytosol] (Xenopus tropicalis)