Reactome | PON1,3 hydrolyse ATVL to ATV

PON1,3 hydrolyse ATVL to ATV

Stable Identifier

R-HSA-9756177

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Serum paraoxonase/arylesterase 1 and Serum paraoxonase/lactonase 3 (PON1 and PON3 respectively) were identified as the major enzymes involved in the hydrolysis of atorvastatin-lactone (ATVL) to atorvastatin (ATV) in human liver (Riedmaier et al. 2011). They are predominantly associated with the ER membrane (Gonzalvo et al. 1998, Riedmaier et al. 2011). It is very likely that these two enzymes also convert the corresponding hydroxyl-metabolites.

Literature References

PubMed ID	Title	Journal	Year
9414488	Human liver paraoxonase (PON1): subcellular distribution and characterization Villanueva, E, Pla, A, Gil, F, Rodrigo, L, Gonzalvo, MC, Hernandez, AF	J Biochem Mol Toxicol	1998
21852972	Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis Hofmann, U, Winter, S, Klein, K, Schwab, M, Zanger, UM, Riedmaier, S	Front Pharmacol	2011