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ATV [cytosol]
Stable Identifier
R-ALL-9705596
Type
ChemicalDrug
Compartment
cytosol
Synonyms
atorvastatin
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Drug ADME (Bos taurus)
Atorvastatin ADME (Bos taurus)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Bos taurus)
ATVs [cytosol]
ATV [cytosol]
CYP3A4 monooxygenates ATV to 2-OH-ATV (Bos taurus)
ATV [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Bos taurus)
ATV [cytosol]
PON1,3 hydrolyse ATVL to ATV (Bos taurus)
ATV [cytosol]
SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Bos taurus)
ATV [cytosol]
UGT1A3 lactonizes ATV to ATVL (Bos taurus)
ATV [cytosol]
Metabolism (Bos taurus)
Metabolism of lipids (Bos taurus)
Metabolism of steroids (Bos taurus)
Cholesterol biosynthesis (Bos taurus)
HMGCR dimer binds statins (Bos taurus)
statins [cytosol]
ATV [cytosol]
HMGCR dimer:statins [endoplasmic reticulum membrane] (Bos taurus)
statins [cytosol]
ATV [cytosol]
Drug ADME (Caenorhabditis elegans)
Atorvastatin ADME (Caenorhabditis elegans)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Caenorhabditis elegans)
ATVs [cytosol]
ATV [cytosol]
PON1,3 hydrolyse ATVL to ATV (Caenorhabditis elegans)
ATV [cytosol]
SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Caenorhabditis elegans)
ATV [cytosol]
Metabolism (Caenorhabditis elegans)
Metabolism of lipids (Caenorhabditis elegans)
Metabolism of steroids (Caenorhabditis elegans)
Cholesterol biosynthesis (Caenorhabditis elegans)
HMGCR dimer binds statins (Caenorhabditis elegans)
statins [cytosol]
ATV [cytosol]
HMGCR dimer:statins [endoplasmic reticulum membrane] (Caenorhabditis elegans)
statins [cytosol]
ATV [cytosol]
Drug ADME (Canis familiaris)
Atorvastatin ADME (Canis familiaris)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Canis familiaris)
ATVs [cytosol]
ATV [cytosol]
CYP3A4 monooxygenates ATV to 2-OH-ATV (Canis familiaris)
ATV [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Canis familiaris)
ATV [cytosol]
PON1,3 hydrolyse ATVL to ATV (Canis familiaris)
ATV [cytosol]
SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Canis familiaris)
ATV [cytosol]
Metabolism (Canis familiaris)
Metabolism of lipids (Canis familiaris)
Metabolism of steroids (Canis familiaris)
Cholesterol biosynthesis (Canis familiaris)
HMGCR dimer binds statins (Canis familiaris)
statins [cytosol]
ATV [cytosol]
HMGCR dimer:statins [endoplasmic reticulum membrane] (Canis familiaris)
statins [cytosol]
ATV [cytosol]
Drug ADME (Danio rerio)
Atorvastatin ADME (Danio rerio)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Danio rerio)
ATVs [cytosol]
ATV [cytosol]
CYP3A4 monooxygenates ATV to 2-OH-ATV (Danio rerio)
ATV [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Danio rerio)
ATV [cytosol]
PON1,3 hydrolyse ATVL to ATV (Danio rerio)
ATV [cytosol]
SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Danio rerio)
ATV [cytosol]
Metabolism (Danio rerio)
Metabolism of lipids (Danio rerio)
Metabolism of steroids (Danio rerio)
Cholesterol biosynthesis (Danio rerio)
HMGCR dimer binds statins (Danio rerio)
statins [cytosol]
ATV [cytosol]
HMGCR dimer:statins [endoplasmic reticulum membrane] (Danio rerio)
statins [cytosol]
ATV [cytosol]
Drug ADME (Dictyostelium discoideum)
Atorvastatin ADME (Dictyostelium discoideum)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Dictyostelium discoideum)
ATVs [cytosol]
ATV [cytosol]
UGT1A3 lactonizes ATV to ATVL (Dictyostelium discoideum)
ATV [cytosol]
Metabolism (Dictyostelium discoideum)
Metabolism of lipids (Dictyostelium discoideum)
Metabolism of steroids (Dictyostelium discoideum)
Cholesterol biosynthesis (Dictyostelium discoideum)
HMGCR dimer binds statins (Dictyostelium discoideum)
statins [cytosol]
ATV [cytosol]
HMGCR dimer:statins [endoplasmic reticulum membrane] (Dictyostelium discoideum)
statins [cytosol]
ATV [cytosol]
Drug ADME (Drosophila melanogaster)
Atorvastatin ADME (Drosophila melanogaster)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Drosophila melanogaster)
ATVs [cytosol]
ATV [cytosol]
SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Drosophila melanogaster)
ATV [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of lipids (Drosophila melanogaster)
Metabolism of steroids (Drosophila melanogaster)
Cholesterol biosynthesis (Drosophila melanogaster)
HMGCR dimer binds statins (Drosophila melanogaster)
statins [cytosol]
ATV [cytosol]
HMGCR dimer:statins [endoplasmic reticulum membrane] (Drosophila melanogaster)
statins [cytosol]
ATV [cytosol]
Drug ADME (Gallus gallus)
Atorvastatin ADME (Gallus gallus)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Gallus gallus)
ATVs [cytosol]
ATV [cytosol]
CYP3A4 monooxygenates ATV to 2-OH-ATV (Gallus gallus)
ATV [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Gallus gallus)
ATV [cytosol]
PON1,3 hydrolyse ATVL to ATV (Gallus gallus)
ATV [cytosol]
SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Gallus gallus)
ATV [cytosol]
UGT1A3 lactonizes ATV to ATVL (Gallus gallus)
ATV [cytosol]
Metabolism (Gallus gallus)
Metabolism of lipids (Gallus gallus)
Metabolism of steroids (Gallus gallus)
Cholesterol biosynthesis (Gallus gallus)
HMGCR dimer binds statins (Gallus gallus)
statins [cytosol]
ATV [cytosol]
HMGCR dimer:statins [endoplasmic reticulum membrane] (Gallus gallus)
statins [cytosol]
ATV [cytosol]
Drug ADME (Homo sapiens)
Atorvastatin ADME (Homo sapiens)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Homo sapiens)
ATVs [cytosol]
ATV [cytosol]
CYP3A4 monooxygenates ATV to 2-OH-ATV (Homo sapiens)
ATV [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Homo sapiens)
ATV [cytosol]
PON1,3 hydrolyse ATVL to ATV (Homo sapiens)
ATV [cytosol]
SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Homo sapiens)
ATV [cytosol]
UGT1A3 lactonizes ATV to ATVL (Homo sapiens)
ATV [cytosol]
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Cholesterol biosynthesis (Homo sapiens)
HMGCR dimer binds statins (Homo sapiens)
statins [cytosol]
ATV [cytosol]
HMGCR dimer:statins [endoplasmic reticulum membrane] (Homo sapiens)
statins [cytosol]
ATV [cytosol]
Drug ADME (Mus musculus)
Atorvastatin ADME (Mus musculus)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Mus musculus)
ATVs [cytosol]
ATV [cytosol]
CYP3A4 monooxygenates ATV to 2-OH-ATV (Mus musculus)
ATV [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Mus musculus)
ATV [cytosol]
PON1,3 hydrolyse ATVL to ATV (Mus musculus)
ATV [cytosol]
SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Mus musculus)
ATV [cytosol]
UGT1A3 lactonizes ATV to ATVL (Mus musculus)
ATV [cytosol]
Metabolism (Mus musculus)
Metabolism of lipids (Mus musculus)
Metabolism of steroids (Mus musculus)
Cholesterol biosynthesis (Mus musculus)
HMGCR dimer binds statins (Mus musculus)
statins [cytosol]
ATV [cytosol]
HMGCR dimer:statins [endoplasmic reticulum membrane] (Mus musculus)
statins [cytosol]
ATV [cytosol]
Drug ADME (Plasmodium falciparum)
Atorvastatin ADME (Plasmodium falciparum)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Plasmodium falciparum)
ATVs [cytosol]
ATV [cytosol]
Drug ADME (Rattus norvegicus)
Atorvastatin ADME (Rattus norvegicus)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Rattus norvegicus)
ATVs [cytosol]
ATV [cytosol]
CYP3A4 monooxygenates ATV to 2-OH-ATV (Rattus norvegicus)
ATV [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Rattus norvegicus)
ATV [cytosol]
PON1,3 hydrolyse ATVL to ATV (Rattus norvegicus)
ATV [cytosol]
SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Rattus norvegicus)
ATV [cytosol]
UGT1A3 lactonizes ATV to ATVL (Rattus norvegicus)
ATV [cytosol]
Metabolism (Rattus norvegicus)
Metabolism of lipids (Rattus norvegicus)
Metabolism of steroids (Rattus norvegicus)
Cholesterol biosynthesis (Rattus norvegicus)
HMGCR dimer binds statins (Rattus norvegicus)
statins [cytosol]
ATV [cytosol]
HMGCR dimer:statins [endoplasmic reticulum membrane] (Rattus norvegicus)
statins [cytosol]
ATV [cytosol]
Drug ADME (Saccharomyces cerevisiae)
Atorvastatin ADME (Saccharomyces cerevisiae)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Saccharomyces cerevisiae)
ATVs [cytosol]
ATV [cytosol]
Metabolism (Saccharomyces cerevisiae)
Metabolism of lipids (Saccharomyces cerevisiae)
Metabolism of steroids (Saccharomyces cerevisiae)
Cholesterol biosynthesis (Saccharomyces cerevisiae)
HMGCR dimer binds statins (Saccharomyces cerevisiae)
statins [cytosol]
ATV [cytosol]
HMGCR dimer:statins [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)
statins [cytosol]
ATV [cytosol]
Drug ADME (Schizosaccharomyces pombe)
Atorvastatin ADME (Schizosaccharomyces pombe)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Schizosaccharomyces pombe)
ATVs [cytosol]
ATV [cytosol]
Metabolism (Schizosaccharomyces pombe)
Metabolism of lipids (Schizosaccharomyces pombe)
Metabolism of steroids (Schizosaccharomyces pombe)
Cholesterol biosynthesis (Schizosaccharomyces pombe)
HMGCR dimer binds statins (Schizosaccharomyces pombe)
statins [cytosol]
ATV [cytosol]
HMGCR dimer:statins [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)
statins [cytosol]
ATV [cytosol]
Drug ADME (Sus scrofa)
Atorvastatin ADME (Sus scrofa)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Sus scrofa)
ATVs [cytosol]
ATV [cytosol]
CYP3A4 monooxygenates ATV to 2-OH-ATV (Sus scrofa)
ATV [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Sus scrofa)
ATV [cytosol]
PON1,3 hydrolyse ATVL to ATV (Sus scrofa)
ATV [cytosol]
SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Sus scrofa)
ATV [cytosol]
UGT1A3 lactonizes ATV to ATVL (Sus scrofa)
ATV [cytosol]
Metabolism (Sus scrofa)
Metabolism of lipids (Sus scrofa)
Metabolism of steroids (Sus scrofa)
Cholesterol biosynthesis (Sus scrofa)
HMGCR dimer binds statins (Sus scrofa)
statins [cytosol]
ATV [cytosol]
HMGCR dimer:statins [endoplasmic reticulum membrane] (Sus scrofa)
statins [cytosol]
ATV [cytosol]
Drug ADME (Xenopus tropicalis)
Atorvastatin ADME (Xenopus tropicalis)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Xenopus tropicalis)
ATVs [cytosol]
ATV [cytosol]
CYP3A4 monooxygenates ATV to 2-OH-ATV (Xenopus tropicalis)
ATV [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Xenopus tropicalis)
ATV [cytosol]
PON1,3 hydrolyse ATVL to ATV (Xenopus tropicalis)
ATV [cytosol]
SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Xenopus tropicalis)
ATV [cytosol]
Metabolism (Xenopus tropicalis)
Metabolism of lipids (Xenopus tropicalis)
Metabolism of steroids (Xenopus tropicalis)
Cholesterol biosynthesis (Xenopus tropicalis)
HMGCR dimer binds statins (Xenopus tropicalis)
statins [cytosol]
ATV [cytosol]
HMGCR dimer:statins [endoplasmic reticulum membrane] (Xenopus tropicalis)
statins [cytosol]
ATV [cytosol]
External Reference Information
External Reference
atorvastatin [Guide to Pharmacology:2949]
Participates
as an input of
UGT1A3 lactonizes ATV to ATVL (Homo sapiens)
UGT1A3 lactonizes ATV to ATVL (Mus musculus)
UGT1A3 lactonizes ATV to ATVL (Rattus norvegicus)
UGT1A3 lactonizes ATV to ATVL (Bos taurus)
UGT1A3 lactonizes ATV to ATVL (Sus scrofa)
UGT1A3 lactonizes ATV to ATVL (Gallus gallus)
UGT1A3 lactonizes ATV to ATVL (Dictyostelium discoideum)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Homo sapiens)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Mus musculus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Rattus norvegicus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Canis familiaris)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Bos taurus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Sus scrofa)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Danio rerio)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Xenopus tropicalis)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Gallus gallus)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Homo sapiens)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Mus musculus)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Rattus norvegicus)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Canis familiaris)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Bos taurus)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Sus scrofa)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Danio rerio)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Xenopus tropicalis)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Gallus gallus)
as an output of
PON1,3 hydrolyse ATVL to ATV (Caenorhabditis elegans)
PON1,3 hydrolyse ATVL to ATV (Gallus gallus)
PON1,3 hydrolyse ATVL to ATV (Xenopus tropicalis)
PON1,3 hydrolyse ATVL to ATV (Danio rerio)
SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Homo sapiens)
SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Mus musculus)
SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Rattus norvegicus)
SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Canis familiaris)
SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Bos taurus)
SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Sus scrofa)
SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Danio rerio)
SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Xenopus tropicalis)
SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Gallus gallus)
SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Drosophila melanogaster)
SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Caenorhabditis elegans)
PON1,3 hydrolyse ATVL to ATV (Homo sapiens)
PON1,3 hydrolyse ATVL to ATV (Mus musculus)
PON1,3 hydrolyse ATVL to ATV (Rattus norvegicus)
PON1,3 hydrolyse ATVL to ATV (Canis familiaris)
PON1,3 hydrolyse ATVL to ATV (Bos taurus)
PON1,3 hydrolyse ATVL to ATV (Sus scrofa)
as a member of
ATVs [cytosol]
statins [cytosol]
Other forms of this molecule
ATV [extracellular region]
Disease
Name
Identifier
Synonyms
familial hypercholesterolemia
DOID:13810
Fredrickson type IIa hyperlipoproteinemia, type II hyperlipidemia, hyperbetalipoproteinemia, familial hypercholesteremia, familial hyperbetalipoproteinaemia, Fredrickson type IIa lipidaemia
cardiovascular system disease
DOID:1287
disease of subdivision of hemolymphoid system
Cross References
ChEBI
50690
PharmacoDB
PDBC02200
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