Reactome | PON1,3 hydrolyse 2-OH-ATVL to 2-OH-ATV

PON1,3 hydrolyse 2-OH-ATVL to 2-OH-ATV

Stable Identifier

R-HSA-9756136

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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Serum paraoxonase/arylesterase 1 and Serum paraoxonase/lactonase 3 (PON1 and PON3 respectively) were identified as the major enzymes involved in the hydrolysis of atorvastatin-lactone (ATVL) to atorvastatin (ATV) in human liver (Riedmaier et al. 2011). They are predominantly associated with the ER membrane (Gonzalvo et al. 1998, Riedmaier et al. 2011). It is very likely that these two enzymes also convert the corresponding 2-hydroxyl-metabolite.

Literature References

PubMed ID	Title	Journal	Year
9414488	Human liver paraoxonase (PON1): subcellular distribution and characterization Gonzalvo, MC, Gil, F, Hernandez, AF, Rodrigo, L, Villanueva, E, Pla, A	J Biochem Mol Toxicol	1998
21852972	Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis Riedmaier, S, Klein, K, Winter, S, Hofmann, U, Schwab, M, Zanger, UM	Front Pharmacol	2011