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ATVL [cytosol]
Stable Identifier
R-ALL-9756319
Type
ChemicalDrug
Compartment
cytosol
Synonyms
atorvastatin lactone
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Drug ADME (Bos taurus)
Atorvastatin ADME (Bos taurus)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Bos taurus)
ATVs [cytosol]
ATVL [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Bos taurus)
ATVL [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Bos taurus)
ATVL [cytosol]
PON1,3 hydrolyse ATVL to ATV (Bos taurus)
ATVL [cytosol]
UGT1A3 lactonizes ATV to ATVL (Bos taurus)
ATVL [cytosol]
Drug ADME (Caenorhabditis elegans)
Atorvastatin ADME (Caenorhabditis elegans)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Caenorhabditis elegans)
ATVs [cytosol]
ATVL [cytosol]
PON1,3 hydrolyse ATVL to ATV (Caenorhabditis elegans)
ATVL [cytosol]
Drug ADME (Canis familiaris)
Atorvastatin ADME (Canis familiaris)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Canis familiaris)
ATVs [cytosol]
ATVL [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Canis familiaris)
ATVL [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Canis familiaris)
ATVL [cytosol]
PON1,3 hydrolyse ATVL to ATV (Canis familiaris)
ATVL [cytosol]
Drug ADME (Danio rerio)
Atorvastatin ADME (Danio rerio)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Danio rerio)
ATVs [cytosol]
ATVL [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Danio rerio)
ATVL [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Danio rerio)
ATVL [cytosol]
PON1,3 hydrolyse ATVL to ATV (Danio rerio)
ATVL [cytosol]
Drug ADME (Dictyostelium discoideum)
Atorvastatin ADME (Dictyostelium discoideum)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Dictyostelium discoideum)
ATVs [cytosol]
ATVL [cytosol]
UGT1A3 lactonizes ATV to ATVL (Dictyostelium discoideum)
ATVL [cytosol]
Drug ADME (Drosophila melanogaster)
Atorvastatin ADME (Drosophila melanogaster)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Drosophila melanogaster)
ATVs [cytosol]
ATVL [cytosol]
Drug ADME (Gallus gallus)
Atorvastatin ADME (Gallus gallus)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Gallus gallus)
ATVs [cytosol]
ATVL [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Gallus gallus)
ATVL [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Gallus gallus)
ATVL [cytosol]
PON1,3 hydrolyse ATVL to ATV (Gallus gallus)
ATVL [cytosol]
UGT1A3 lactonizes ATV to ATVL (Gallus gallus)
ATVL [cytosol]
Drug ADME (Homo sapiens)
Atorvastatin ADME (Homo sapiens)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Homo sapiens)
ATVs [cytosol]
ATVL [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Homo sapiens)
ATVL [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Homo sapiens)
ATVL [cytosol]
PON1,3 hydrolyse ATVL to ATV (Homo sapiens)
ATVL [cytosol]
UGT1A3 lactonizes ATV to ATVL (Homo sapiens)
ATVL [cytosol]
Drug ADME (Mus musculus)
Atorvastatin ADME (Mus musculus)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Mus musculus)
ATVs [cytosol]
ATVL [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Mus musculus)
ATVL [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Mus musculus)
ATVL [cytosol]
PON1,3 hydrolyse ATVL to ATV (Mus musculus)
ATVL [cytosol]
UGT1A3 lactonizes ATV to ATVL (Mus musculus)
ATVL [cytosol]
Drug ADME (Plasmodium falciparum)
Atorvastatin ADME (Plasmodium falciparum)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Plasmodium falciparum)
ATVs [cytosol]
ATVL [cytosol]
Drug ADME (Rattus norvegicus)
Atorvastatin ADME (Rattus norvegicus)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Rattus norvegicus)
ATVs [cytosol]
ATVL [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Rattus norvegicus)
ATVL [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Rattus norvegicus)
ATVL [cytosol]
PON1,3 hydrolyse ATVL to ATV (Rattus norvegicus)
ATVL [cytosol]
UGT1A3 lactonizes ATV to ATVL (Rattus norvegicus)
ATVL [cytosol]
Drug ADME (Saccharomyces cerevisiae)
Atorvastatin ADME (Saccharomyces cerevisiae)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Saccharomyces cerevisiae)
ATVs [cytosol]
ATVL [cytosol]
Drug ADME (Schizosaccharomyces pombe)
Atorvastatin ADME (Schizosaccharomyces pombe)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Schizosaccharomyces pombe)
ATVs [cytosol]
ATVL [cytosol]
Drug ADME (Sus scrofa)
Atorvastatin ADME (Sus scrofa)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Sus scrofa)
ATVs [cytosol]
ATVL [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Sus scrofa)
ATVL [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Sus scrofa)
ATVL [cytosol]
PON1,3 hydrolyse ATVL to ATV (Sus scrofa)
ATVL [cytosol]
UGT1A3 lactonizes ATV to ATVL (Sus scrofa)
ATVL [cytosol]
Drug ADME (Xenopus tropicalis)
Atorvastatin ADME (Xenopus tropicalis)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Xenopus tropicalis)
ATVs [cytosol]
ATVL [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Xenopus tropicalis)
ATVL [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Xenopus tropicalis)
ATVL [cytosol]
PON1,3 hydrolyse ATVL to ATV (Xenopus tropicalis)
ATVL [cytosol]
External Reference Information
External Reference
atorvastatin lactone [Guide to Pharmacology:2957]
Participates
as an input of
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Gallus gallus)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Xenopus tropicalis)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Danio rerio)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Sus scrofa)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Bos taurus)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Canis familiaris)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Rattus norvegicus)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Mus musculus)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Homo sapiens)
PON1,3 hydrolyse ATVL to ATV (Caenorhabditis elegans)
PON1,3 hydrolyse ATVL to ATV (Gallus gallus)
PON1,3 hydrolyse ATVL to ATV (Xenopus tropicalis)
PON1,3 hydrolyse ATVL to ATV (Danio rerio)
PON1,3 hydrolyse ATVL to ATV (Sus scrofa)
PON1,3 hydrolyse ATVL to ATV (Bos taurus)
PON1,3 hydrolyse ATVL to ATV (Canis familiaris)
PON1,3 hydrolyse ATVL to ATV (Rattus norvegicus)
PON1,3 hydrolyse ATVL to ATV (Mus musculus)
PON1,3 hydrolyse ATVL to ATV (Homo sapiens)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Gallus gallus)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Xenopus tropicalis)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Danio rerio)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Sus scrofa)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Bos taurus)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Canis familiaris)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Rattus norvegicus)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Mus musculus)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Homo sapiens)
as a member of
ATVs [cytosol]
as an output of
UGT1A3 lactonizes ATV to ATVL (Dictyostelium discoideum)
UGT1A3 lactonizes ATV to ATVL (Gallus gallus)
UGT1A3 lactonizes ATV to ATVL (Sus scrofa)
UGT1A3 lactonizes ATV to ATVL (Bos taurus)
UGT1A3 lactonizes ATV to ATVL (Rattus norvegicus)
UGT1A3 lactonizes ATV to ATVL (Mus musculus)
UGT1A3 lactonizes ATV to ATVL (Homo sapiens)
Other forms of this molecule
ATVL [extracellular region]
Disease
Name
Identifier
Synonyms
cardiovascular system disease
DOID:1287
disease of subdivision of hemolymphoid system
familial hypercholesterolemia
DOID:13810
Fredrickson type IIa hyperlipoproteinemia, type II hyperlipidemia, hyperbetalipoproteinemia, familial hypercholesteremia, familial hyperbetalipoproteinaemia, Fredrickson type IIa lipidaemia
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