Reactome | HTR3C [plasma membrane]

HTR3C [plasma membrane]

Stable Identifier

R-HSA-975312

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

5-hydroxytryptamine receptor 3C, 5HT3C_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Homo sapiens)
      - HTR3 pentamers:5HT [plasma membrane] (Homo sapiens)
        
        HTR3 pentamers [plasma membrane] (Homo sapiens)
        
        2xHTR3A:3xHTR3C [plasma membrane] (Homo sapiens)
        
        HTR3C [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8WXA8 HTR3C

Gene Names

HTR3C

Chain

signal peptide:1-27, chain:28-447

Reference Genes

BioGPS Gene:170572 HTR3C

COSMIC (genes):HTR3C HTR3C

CTD Gene:170572 HTR3C

dbSNP Gene:170572 HTR3C

ENSEMBL:ENSG00000178084 HTR3C

HGNC:24003 HTR3C

KEGG:hsa:170572 HTR3C

Monarch:170572 HTR3C

NCBI Gene:170572 HTR3C

OMIM:610121 HTR3C

UCSC:Q8WXA8 HTR3C

Reference Transcript

RefSeq:NM_130770.2 HTR3C

Other Identifiers

11741929_at

16948648

170572

2655319

2655320

2655327

2655328

2655329

2655330

2655331

2655332

2655333

2655335

2655336

2655337

2655347

8084275

A_14_P134187

GE486397

GO:0004888

GO:0005215

GO:0005216

GO:0005230

GO:0005231

GO:0005515

GO:0005886

GO:0006811

GO:0007210

GO:0016020

GO:0022850

GO:0034220

GO:0043005

GO:0045202

GO:0045211

GO:0055085

GO:0060078

GO:0060079

GO:0060089

GO:0098662

GO:0140227

GO:1902495

GO:1904315

GO:1904602

HMNXSV003010709

ILMN_1739275

PH_hs_0017041

TC03000990.hg

Participates

as a component of

2xHTR3A:3xHTR3C [plasma membrane] (Homo sapiens)

Inferred To

lgc-7 [plasma membrane] (Caenorhabditis elegans)

lgc-9 [plasma membrane] (Caenorhabditis elegans)

lgc-4 [plasma membrane] (Caenorhabditis elegans)

HTR3C [plasma membrane] (Canis familiaris)

HTR3C [plasma membrane] (Sus scrofa)

lgc-12 [plasma membrane] (Caenorhabditis elegans)

lgc-31 [plasma membrane] (Caenorhabditis elegans)

lgc-6 [plasma membrane] (Caenorhabditis elegans)

acr-20 [plasma membrane] (Caenorhabditis elegans)

lgc-11 [plasma membrane] (Caenorhabditis elegans)

lgc-8 [plasma membrane] (Caenorhabditis elegans)

Homologues of HTR3C [plasma membrane] (Caenorhabditis elegans)

deg-3 [plasma membrane] (Caenorhabditis elegans)

acr-23 [plasma membrane] (Caenorhabditis elegans)

acr-5 [plasma membrane] (Caenorhabditis elegans)

lgc-10 [plasma membrane] (Caenorhabditis elegans)

acr-24 [plasma membrane] (Caenorhabditis elegans)

acr-21 [plasma membrane] (Caenorhabditis elegans)

lgc-5 [plasma membrane] (Caenorhabditis elegans)

des-2 [plasma membrane] (Caenorhabditis elegans)

lgc-30 [plasma membrane] (Caenorhabditis elegans)

Cross References

Guide to Pharmacology - Targets

375

ENSEMBL

ENSP00000322617, ENST00000318351, ENSG00000178084

OpenTargets

ENSG00000178084

GeneCards

HTR3C

HPA

ENSG00000178084-HTR3C

PRO

Q8WXA8

Pharos - Targets

Q8WXA8

HMDB Protein

HMDBP12055

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BTN0 LRFN3	1	SALM4 [plasma membrane] (R-HSA-197704)	0.527	2
UniProt:P17302 GJA1	7	GJA1 [Golgi-associated vesicle membrane] (R-HSA-190544) GJA1 [plasma membrane] (R-HSA-158058) p-Y265-GJA1 [plasma membrane] (R-HSA-191657) GJA1 [lysosomal membrane] (R-HSA-196173) GJA1 [endoplasmic reticulum membrane] (R-HSA-190654) GJA1 [Golgi membrane] (R-HSA-190649) p-S373-GJA1 [plasma membrane] (R-HSA-9857671)	0.527	2
UniProt:Q14118 DAG1	15	DAG1(654-895) [plasma membrane] (R-HSA-2328154) DAG1(30-653) [extracellular region] (R-HSA-2328152) DAG1(30-653) [cytosol] (R-HSA-5615641) DAG1(30-653) [endoplasmic reticulum lumen] (R-HSA-8931890) Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-5615647) GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931673) GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931656) GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931659) Man-DAG1 [Golgi lumen] (R-HSA-8931888) GlcNAc,1,2-Man-DAG1 [Golgi lumen] (R-HSA-5617087) GlcNAc-1,6-(GlcNAc-1,2)-Man-DAG1 [extracellular region] (R-HSA-9913190) GlcNAc-1,6-(GlcNAc-1,2)-Man-DAG1 [Golgi lumen] (R-HSA-8932424) DAG1(654-895) [Golgi membrane] (R-HSA-9913184) DAG1(654-895) [endoplasmic reticulum membrane] (R-HSA-9913257) DAG1 [endoplasmic reticulum membrane] (R-HSA-9913254)	0.527	2

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