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GJA1 [lysosomal membrane]
Stable Identifier
R-HSA-196173
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal membrane
Synonyms
Connexin 43
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Gap junction trafficking and regulation (Homo sapiens)
Gap junction trafficking (Homo sapiens)
Gap junction degradation (Homo sapiens)
Internalization of gap junction plaques (Homo sapiens)
Invaginating gap junction plaques [lysosomal membrane] (Homo sapiens)
planar gap junction plaques containing Dab2 [lysosomal membrane] (Homo sapiens)
junctional plaque prior to invagination [lysosomal membrane] (Homo sapiens)
gap junction plaque [lysosomal membrane] (Homo sapiens)
Junctional channel [lysosomal membrane] (Homo sapiens)
Hemi-channels [lysosomal membrane] (Homo sapiens)
Connexin 43 hemi-channel [lysosomal membrane] (Homo sapiens)
GJA1 [lysosomal membrane] (Homo sapiens)
Lysosomal degradation of gap junction plaques (Homo sapiens)
Invaginating gap junction plaques [lysosomal membrane] (Homo sapiens)
planar gap junction plaques containing Dab2 [lysosomal membrane] (Homo sapiens)
junctional plaque prior to invagination [lysosomal membrane] (Homo sapiens)
gap junction plaque [lysosomal membrane] (Homo sapiens)
Junctional channel [lysosomal membrane] (Homo sapiens)
Hemi-channels [lysosomal membrane] (Homo sapiens)
Connexin 43 hemi-channel [lysosomal membrane] (Homo sapiens)
GJA1 [lysosomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17302 GJA1
Gene Names
GJA1, GJAL
Chain
chain:1-382
Reference Genes
BioGPS Gene:2697 GJA1
COSMIC (genes):GJA1 GJA1
CTD Gene:2697 GJA1
dbSNP Gene:2697 GJA1
ENSEMBL:ENSG00000152661 GJA1
HGNC:4274 GJA1
KEGG Gene (Homo sapiens):2697 GJA1
Monarch:2697 GJA1
NCBI Gene:2697 GJA1
OMIM:121014 GJA1
UCSC:P17302 GJA1
Reference Transcript
RefSeq:NM_000165.4 GJA1
Other Identifiers
0002650471
10753
11716326_a_at
11716327_x_at
11716328_a_at
11716329_s_at
17012148
201667_at
2018_at
2697
2870350
2923662
2923665
2923667
2923668
2LL2
32531_at
35097
47551
69245
8121749
A_14_P200744
A_24_P55295
AAA52131
AAD37802
AAH26329
AF151980
AK312324
AL139098
BAG35246
BC026329
CAA37122
CAB010753
CAG46461
CCDS5123
CH471051
CR541660
EAW48178
ENSG00000152661
ENSP00000282561
ENSP00000497283
ENSP00000497367
ENSP00000497565
ENST00000282561
ENST00000282561.4
ENST00000647564
ENST00000647564.1
ENST00000649003
ENST00000649003.1
ENST00000650427
ENST00000650427.1
EntrezGene:2697
EntrezGene:GJA1
g4755136_3p_at
GE58210
GJA1
GJA1-201
GJA1-202
GJA1-203
GJA1-204
GO:0000003
GO:0000132
GO:0000139
GO:0000278
GO:0000902
GO:0001937
GO:0002544
GO:0002931
GO:0003013
GO:0003104
GO:0003158
GO:0003674
GO:0005243
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005741
GO:0005764
GO:0005768
GO:0005769
GO:0005770
GO:0005771
GO:0005773
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0005887
GO:0005916
GO:0005921
GO:0005922
GO:0005925
GO:0006259
GO:0006810
GO:0006915
GO:0006936
GO:0006950
GO:0007010
GO:0007049
GO:0007154
GO:0007165
GO:0007204
GO:0007267
GO:0007283
GO:0007507
GO:0008013
GO:0008092
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0009056
GO:0009058
GO:0009268
GO:0009749
GO:0009790
GO:0010232
GO:0010644
GO:0010652
GO:0014047
GO:0014704
GO:0015031
GO:0015075
GO:0015562
GO:0015631
GO:0015867
GO:0016020
GO:0016021
GO:0016264
GO:0016324
GO:0017124
GO:0019904
GO:0022607
GO:0022857
GO:0022898
GO:0030054
GO:0030154
GO:0030165
GO:0030308
GO:0030660
GO:0031410
GO:0032024
GO:0032277
GO:0032355
GO:0032496
GO:0032526
GO:0032991
GO:0034220
GO:0034330
GO:0034405
GO:0034613
GO:0034634
GO:0034641
GO:0040007
GO:0040011
GO:0042592
GO:0042981
GO:0043123
GO:0043226
GO:0043231
GO:0043434
GO:0044291
GO:0045121
GO:0045732
GO:0045907
GO:0046697
GO:0046849
GO:0048646
GO:0048812
GO:0048856
GO:0048870
GO:0051259
GO:0051924
GO:0055077
GO:0055085
GO:0060044
GO:0060348
GO:0061045
GO:0065003
GO:0070160
GO:0071253
GO:0071260
GO:0071374
GO:0086014
GO:0086064
GO:0086075
GO:0097718
GO:0097755
GO:0120162
GO:0140115
GO:1901164
GO:1903763
GO:1904646
GO:1905332
GO:1905772
GO:1905867
GO:2000279
GO:2000648
GO:2000810
GO:2000987
HGNC:4274
HPA035097
HPA047551
HPA069245
ILMN_1727087
IPR000500
IPR002261
IPR013092
IPR013124
IPR017990
IPR019570
IPR034634
IPR035091
IPR038359
M65188
MIM:104100
MIM:121014
MIM:164200
MIM:186100
MIM:218400
MIM:241550
MIM:257850
MIM:600309
MIM:617525
NM_000165
NP_000156
PF00029
PF03508
PH_hs_0028961
PR00206
PR01132
SM00037
SM01089
TC06000945.hg
U64573_s_at
UPI000013DCEC
X52947
X52947_at
Participant Of
hasComponent
Connexin 43 hemi-channel [lysosomal membrane]
Other forms of this molecule
GJA1 [endoplasmic reticulum membrane]
GJA1 [Golgi membrane]
p-Y265-GJA1 [plasma membrane]
GJA1 [Golgi-associated vesicle membrane]
GJA1 [plasma membrane]
Inferred To
GJA1 [lysosomal membrane] (Danio rerio)
GJA1 [lysosomal membrane] (Mus musculus)
GJA1 [lysosomal membrane] (Rattus norvegicus)
GJA1 [lysosomal membrane] (Sus scrofa)
GJA1 [lysosomal membrane] (Xenopus tropicalis)
Cross References
RefSeq
NP_000156.1
OpenTargets
ENSG00000152661
GeneCards
P17302
PRO
P17302
Orphanet
16125
PDB
2LL2
HMDB Protein
HMDBP01740
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43889-2 CREB3
0.666
4
UniProt:Q07157 TJP1
5
TJP1 [plasma membrane]
(R-HSA-3209845)
TJP1 [cytosol]
(R-HSA-532659)
TJP1 (?-?) [plasma membrane]
(R-HSA-3209844)
TJP1 [cell junction]
(R-HSA-8936023)
TJP1 [Golgi-associated vesicle membrane]
(R-HSA-3209843)
0.646
3
UniProt:Q5BJH2-2 TMEM128
0.488
2
UniProt:Q5VZY2 PLPP4
1
PPAPDC1A [plasma membrane]
(R-HSA-2029082)
0.488
2
UniProt:Q9NZG7 NINJ2
0.488
2
UniProt:Q8N661 TMEM86B
1
TMEM86B [endoplasmic reticulum membrane]
(R-HSA-8874443)
0.488
2
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