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p-Y265-GJA1 [plasma membrane]
Stable Identifier
R-HSA-191657
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
phospho-tyrosine 265 Cx43
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Gap junction trafficking and regulation (Homo sapiens)
Regulation of gap junction activity (Homo sapiens)
Closure of gap junction (Homo sapiens)
c-src-associated Cx43 junctional channel [plasma membrane] (Homo sapiens)
c-src associated cx43 hemi-channel [plasma membrane] (Homo sapiens)
p-Y265-GJA1 [plasma membrane] (Homo sapiens)
closed Cx43 junctional channel [plasma membrane] (Homo sapiens)
c-src associated cx43 hemi-channel [plasma membrane] (Homo sapiens)
p-Y265-GJA1 [plasma membrane] (Homo sapiens)
Phosphorylation of Cx43 by c-src (Homo sapiens)
phospho-Y265 Cx43:ZO-1 gap junction [plasma membrane] (Homo sapiens)
phospho-Y265 Cx43:ZO-1:c-src hemi-channel [plasma membrane] (Homo sapiens)
p-Y265-GJA1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17302 GJA1
Gene Names
GJA1, GJAL
Chain
initiator methionine:, chain:2-382
Reference Genes
BioGPS Gene:2697 GJA1
COSMIC (genes):GJA1 GJA1
CTD Gene:2697 GJA1
dbSNP Gene:2697 GJA1
ENSEMBL:ENSG00000152661 GJA1
ENSEMBL_homo_sapiens_GENE:ENSG00000152661.9 GJA1
HGNC:4274 GJA1
KEGG Gene (Homo sapiens):2697 GJA1
Monarch:2697 GJA1
NCBI Gene:2697 GJA1
OMIM:121014 GJA1
UCSC:P17302 GJA1
Reference Transcript
RefSeq:NM_000165.4 GJA1
Other Identifiers
11716326_a_at
11716327_x_at
11716328_a_at
11716329_s_at
17012148
201667_PM_at
201667_at
2018_at
2697
2870350
2923662
2923665
2923667
2923668
32531_at
8121749
A_14_P200744
A_24_P55295
GE58210
GO:0000132
GO:0000139
GO:0000278
GO:0001649
GO:0001701
GO:0001764
GO:0001947
GO:0002069
GO:0002088
GO:0002376
GO:0003012
GO:0003013
GO:0003161
GO:0003294
GO:0005102
GO:0005215
GO:0005243
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0005856
GO:0005882
GO:0005886
GO:0005911
GO:0005916
GO:0005921
GO:0005922
GO:0005925
GO:0007010
GO:0007154
GO:0007163
GO:0007165
GO:0007267
GO:0007283
GO:0007507
GO:0007512
GO:0008013
GO:0008016
GO:0008092
GO:0008104
GO:0008584
GO:0010628
GO:0010629
GO:0010643
GO:0010644
GO:0014047
GO:0014704
GO:0015075
GO:0015562
GO:0015631
GO:0016020
GO:0016264
GO:0016324
GO:0016328
GO:0022414
GO:0022857
GO:0023052
GO:0030054
GO:0030154
GO:0030308
GO:0030500
GO:0030660
GO:0031410
GO:0032277
GO:0034220
GO:0034330
GO:0034634
GO:0034775
GO:0035050
GO:0035633
GO:0042098
GO:0042110
GO:0042733
GO:0042908
GO:0043123
GO:0043226
GO:0043231
GO:0043292
GO:0043403
GO:0044291
GO:0045121
GO:0045216
GO:0045844
GO:0046849
GO:0046850
GO:0048487
GO:0048514
GO:0048856
GO:0048870
GO:0050886
GO:0055077
GO:0055085
GO:0060156
GO:0060307
GO:0060348
GO:0060371
GO:0060373
GO:0061337
GO:0070160
GO:0070161
GO:0071467
GO:0086014
GO:0086064
GO:0086075
GO:0097110
GO:0097402
GO:0120162
GO:0140115
GO:1901164
GO:1903763
GO:1904646
GO:1904707
GO:1905332
GO:1905772
GO:1990782
GO:2000648
HMNXSV003054192
ILMN_1727087
PH_hs_0028961
TC06000945.hg
U64573_s_at
X52947_at
g4755136_3p_at
Participates
as a component of
c-src associated cx43 hemi-channel [plasma membrane] (Homo sapiens)
phospho-Y265 Cx43:ZO-1:c-src hemi-channel [plasma membrane] (Homo sapiens)
Other forms of this molecule
GJA1 [Golgi membrane]
GJA1 [endoplasmic reticulum membrane]
GJA1 [lysosomal membrane]
GJA1 [plasma membrane]
GJA1 [Golgi-associated vesicle membrane]
Inferred To
phospho-Gja1 [plasma membrane]
(Mus musculus)
phospho-Gja1 [plasma membrane]
(Rattus norvegicus)
phospho-CXNK1 [plasma membrane]
(Canis familiaris)
phospho-GJA1 [plasma membrane]
(Bos taurus)
phospho-GJA1 [plasma membrane]
(Gallus gallus)
phospho-GJA1 [plasma membrane]
(Sus scrofa)
phospho-gja1 [plasma membrane]
(Danio rerio)
Modified Residues
Name
O4'-phospho-L-tyrosine at 265
Coordinate
265
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_000156.1
Guide to Pharmacology - Targets
728
OpenTargets
ENSG00000152661
GeneCards
P17302
HPA
ENSG00000152661-GJA1
Ensembl
ENSP00000497283
,
ENST00000282561
,
ENSG00000152661
,
ENST00000650427
,
ENSP00000282561
,
ENSP00000497367
,
ENSP00000497565
,
ENST00000649003
,
ENST00000647564
PRO
P17302
Pharos - Targets
P17302
Orphanet
16125
HMDB Protein
HMDBP01740
PDB
7XQF
,
7XQJ
,
7XQD
,
2LL2
,
7F94
,
7Z23
,
7Z22
,
7F93
,
7XQI
,
7XQB
,
7Z1T
,
7XQH
,
7F92
,
7XQG
,
7XQ9
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43889-2 CREB3
0.666
4
UniProt:Q07157 TJP1
5
TJP1 [cell junction]
(R-HSA-8936023)
TJP1 (?-?) [plasma membrane]
(R-HSA-3209844)
TJP1 [plasma membrane]
(R-HSA-3209845)
TJP1 [Golgi-associated vesicle membrane]
(R-HSA-3209843)
TJP1 [cytosol]
(R-HSA-532659)
0.646
3
UniProt:Q8N661 TMEM86B
1
TMEM86B [endoplasmic reticulum membrane]
(R-HSA-8874443)
0.556
3
UniProt:Q8TAB5 CA216
0.556
3
UniProt:Q5VZY2 PLPP4
1
PPAPDC1A [plasma membrane]
(R-HSA-2029082)
0.556
3
UniProt:Q9NP61 ARFGAP3
1
ARFGAP3 [cytosol]
(R-HSA-6807740)
0.556
3
UniProt:Q5BJH2-2 TMEM128
0.556
3
UniProt:P48730-2 CSNK1D
0.556
3
UniProt:Q9NZG7 NINJ2
0.556
3
UniProt:Q99679 GPR21
0.527
2
UniProt:P16444 DPEP1
1
DPEP1 [plasma membrane]
(R-HSA-2142820)
0.527
2
UniProt:Q401N2 ZACN
0.527
2
UniProt:Q8WXA8 HTR3C
1
HTR3C [plasma membrane]
(R-HSA-975312)
0.527
2
UniProt:Q8IZF4 AGRG5
0.527
2
UniProt:O43505 B4GAT1
1
B4GAT1 [Golgi membrane]
(R-HSA-916821)
0.527
2
UniProt:P21589 NT5E
1
NT5E [plasma membrane]
(R-HSA-49191)
0.527
2
UniProt:P08842 STS
3
STS [endoplasmic reticulum lumen]
(R-HSA-1614318)
OxA-STS [endoplasmic reticulum lumen]
(R-HSA-1614333)
OxA-STS [endoplasmic reticulum membrane]
(R-HSA-1606833)
0.527
2
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