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GJA1 [Golgi-associated vesicle membrane]
Stable Identifier
R-HSA-190544
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi-associated vesicle membrane
Synonyms
Connexin 43
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 targets PDZ proteins in cell-cell junction (Homo sapiens)
Association of Cx43 with TJP1 (Homo sapiens)
Connexin 43 connexon in Golgi transport vesicle [Golgi-associated vesicle membrane] (Homo sapiens)
GJA1 [Golgi-associated vesicle membrane] (Homo sapiens)
Cx43:TJP1 [Golgi-associated vesicle membrane] (Homo sapiens)
Connexin 43 connexon in Golgi transport vesicle [Golgi-associated vesicle membrane] (Homo sapiens)
GJA1 [Golgi-associated vesicle membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Gap junction trafficking and regulation (Homo sapiens)
Gap junction trafficking (Homo sapiens)
Gap junction assembly (Homo sapiens)
Docking of connexons into junctional, double-membrane spanning channels (Homo sapiens)
Docked Cx43-containing transport vesicles [plasma membrane] (Homo sapiens)
Connexin 43 connexon in Golgi transport vesicle [Golgi-associated vesicle membrane] (Homo sapiens)
GJA1 [Golgi-associated vesicle membrane] (Homo sapiens)
connexons in Golgi transport vesicle docked to microtubules [cytosol] (Homo sapiens)
Connexin 43 connexon in Golgi transport vesicle [Golgi-associated vesicle membrane] (Homo sapiens)
GJA1 [Golgi-associated vesicle membrane] (Homo sapiens)
Insertion of connexons into the plasma membrane resulting in the formation of hemi-channels (Homo sapiens)
Docked Cx43-containing transport vesicles [plasma membrane] (Homo sapiens)
Connexin 43 connexon in Golgi transport vesicle [Golgi-associated vesicle membrane] (Homo sapiens)
GJA1 [Golgi-associated vesicle membrane] (Homo sapiens)
Transport of connexons to the plasma membrane (Homo sapiens)
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane (Homo sapiens)
Association of Golgi transport vesicles with microtubules (Homo sapiens)
Connexin 43 connexon in Golgi transport vesicle [Golgi-associated vesicle membrane] (Homo sapiens)
GJA1 [Golgi-associated vesicle membrane] (Homo sapiens)
connexons in Golgi transport vesicle docked to microtubules [cytosol] (Homo sapiens)
Connexin 43 connexon in Golgi transport vesicle [Golgi-associated vesicle membrane] (Homo sapiens)
GJA1 [Golgi-associated vesicle membrane] (Homo sapiens)
Budding of connexon-containing transport vesicles from the Golgi (Homo sapiens)
Connexin 43 connexon in Golgi transport vesicle [Golgi-associated vesicle membrane] (Homo sapiens)
GJA1 [Golgi-associated vesicle membrane] (Homo sapiens)
Regulation of gap junction activity (Homo sapiens)
Association of Cx43 with TJP1 (Homo sapiens)
Connexin 43 connexon in Golgi transport vesicle [Golgi-associated vesicle membrane] (Homo sapiens)
GJA1 [Golgi-associated vesicle membrane] (Homo sapiens)
Cx43:TJP1 [Golgi-associated vesicle membrane] (Homo sapiens)
Connexin 43 connexon in Golgi transport vesicle [Golgi-associated vesicle membrane] (Homo sapiens)
GJA1 [Golgi-associated vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17302 GJA1
Gene Names
GJA1, GJAL
Chain
initiator methionine:1, chain:2-382
Reference Genes
BioGPS Gene:2697 GJA1
COSMIC (genes):GJA1 GJA1
CTD Gene:2697 GJA1
dbSNP Gene:2697 GJA1
ENSEMBL:ENSG00000152661.9 GJA1
HGNC:4274 GJA1
KEGG Gene (Homo sapiens):2697 GJA1
Monarch:2697 GJA1
NCBI Gene:2697 GJA1
OMIM:121014 GJA1
UCSC:P17302 GJA1
Reference Transcript
RefSeq:NM_000165.4 GJA1
Other Identifiers
11716326_a_at
11716327_x_at
11716328_a_at
11716329_s_at
17012148
201667_PM_at
201667_at
2018_at
2697
2870350
2923662
2923665
2923667
2923668
32531_at
8121749
A_14_P200744
A_24_P55295
GE58210
GO:0000132
GO:0000139
GO:0000278
GO:0003012
GO:0003013
GO:0003161
GO:0005215
GO:0005243
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0005921
GO:0005922
GO:0005925
GO:0007010
GO:0007154
GO:0007163
GO:0007165
GO:0007267
GO:0007283
GO:0007507
GO:0008013
GO:0008092
GO:0008104
GO:0010628
GO:0010644
GO:0014047
GO:0014704
GO:0015075
GO:0015562
GO:0015631
GO:0016020
GO:0016264
GO:0016324
GO:0022414
GO:0022857
GO:0023052
GO:0030054
GO:0030154
GO:0030308
GO:0030660
GO:0031410
GO:0032277
GO:0034220
GO:0034330
GO:0034634
GO:0034775
GO:0035633
GO:0042908
GO:0043123
GO:0043226
GO:0043231
GO:0044291
GO:0045121
GO:0046849
GO:0048856
GO:0048870
GO:0050886
GO:0055077
GO:0055085
GO:0060348
GO:0070160
GO:0070161
GO:0086014
GO:0086064
GO:0086075
GO:0120162
GO:0140115
GO:1901164
GO:1903763
GO:1904646
GO:1904707
GO:1905332
GO:1905772
GO:2000648
HMNXSV003054192
ILMN_1727087
PH_hs_0028961
TC06000945.hg
U64573_s_at
X52947_at
g4755136_3p_at
Participates
as a component of
Connexin 43 connexon in Golgi transport vesicle [Golgi-associated vesicle membrane] (Homo sapiens)
Other forms of this molecule
GJA1 [plasma membrane]
p-Y265-GJA1 [plasma membrane]
GJA1 [lysosomal membrane]
GJA1 [endoplasmic reticulum membrane]
GJA1 [Golgi membrane]
Inferred To
GJA1 [Golgi-associated vesicle membrane]
(Bos taurus)
GJA1 [Golgi-associated vesicle membrane]
(Canis familiaris)
GJA1 [Golgi-associated vesicle membrane]
(Gallus gallus)
GJA1 [Golgi-associated vesicle membrane]
(Sus scrofa)
gja1 [Golgi-associated vesicle membrane]
(Danio rerio)
gja1 [Golgi-associated vesicle membrane]
(Xenopus tropicalis)
Gja1 [Golgi-associated vesicle membrane]
(Mus musculus)
Gja1 [Golgi-associated vesicle membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_000156.1
Guide to Pharmacology - Targets
728
OpenTargets
ENSG00000152661
HPA
ENSG00000152661-GJA1
GeneCards
P17302
Ensembl
ENSP00000282561
,
ENSP00000497565
,
ENSP00000497367
,
ENST00000282561
,
ENSP00000497283
,
ENST00000650427
,
ENST00000649003
,
ENST00000647564
,
ENSG00000152661
PRO
P17302
Pharos - Targets
P17302
Orphanet
16125
HMDB Protein
HMDBP01740
PDB
7F93
,
7F92
,
7F94
,
2LL2
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43889-2 CREB3
0.666
4
UniProt:Q07157 TJP1
5
TJP1 [cell junction]
(R-HSA-8936023)
TJP1 (?-?) [plasma membrane]
(R-HSA-3209844)
TJP1 [plasma membrane]
(R-HSA-3209845)
TJP1 [Golgi-associated vesicle membrane]
(R-HSA-3209843)
TJP1 [cytosol]
(R-HSA-532659)
0.646
3
UniProt:Q9NP61 ARFGAP3
1
ARFGAP3 [cytosol]
(R-HSA-6807740)
0.556
3
UniProt:Q5BJH2-2 TMEM128
0.556
3
UniProt:Q8N661 TMEM86B
1
TMEM86B [endoplasmic reticulum membrane]
(R-HSA-8874443)
0.556
3
UniProt:Q9NZG7 NINJ2
0.556
3
UniProt:Q5VZY2 PLPP4
1
PPAPDC1A [plasma membrane]
(R-HSA-2029082)
0.556
3
UniProt:Q8TAB5 CA216
0.556
3
UniProt:P48730-2 CSNK1D
0.556
3
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