Reactome | GJA1 [Golgi-associated vesicle membrane]

GJA1 [Golgi-associated vesicle membrane]

Stable Identifier

R-HSA-190544

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi-associated vesicle membrane

Synonyms

Connexin 43

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 targets PDZ proteins in cell-cell junction (Homo sapiens)
        
        Association of Cx43 with TJP1 (Homo sapiens)
        
        Connexin 43 connexon in Golgi transport vesicle [Golgi-associated vesicle membrane] (Homo sapiens)
        
        GJA1 [Golgi-associated vesicle membrane] (Homo sapiens)
        
        Cx43:TJP1 [Golgi-associated vesicle membrane] (Homo sapiens)
        
        Connexin 43 connexon in Golgi transport vesicle [Golgi-associated vesicle membrane] (Homo sapiens)
        
        GJA1 [Golgi-associated vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P17302 GJA1

Gene Names

GJA1, GJAL

Chain

initiator methionine:, chain:2-382

Reference Genes

BioGPS Gene:2697 GJA1

COSMIC (genes):GJA1 GJA1

CTD Gene:2697 GJA1

dbSNP Gene:2697 GJA1

ENSEMBL:ENSG00000152661 GJA1

HGNC:4274 GJA1

KEGG:hsa:2697 GJA1

Monarch:2697 GJA1

NCBI Gene:2697 GJA1

OMIM:121014 GJA1

UCSC:P17302 GJA1

Reference Transcript

RefSeq:NM_000165.5 GJA1

Other Identifiers

11716326_a_at

11716327_x_at

11716328_a_at

11716329_s_at

17012148

201667_PM_at

201667_at

2018_at

2697

2870350

2923662

2923665

2923667

2923668

32531_at

8121749

A_14_P200744

A_24_P55295

GE58210

GO:0000132

GO:0000139

GO:0003161

GO:0005215

GO:0005243

GO:0005515

GO:0005654

GO:0005737

GO:0005739

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0005921

GO:0005922

GO:0005925

GO:0007010

GO:0007154

GO:0007165

GO:0007267

GO:0007283

GO:0007507

GO:0008013

GO:0008092

GO:0008104

GO:0010628

GO:0010644

GO:0014047

GO:0014704

GO:0015075

GO:0015562

GO:0015631

GO:0016264

GO:0016324

GO:0022414

GO:0022857

GO:0023052

GO:0030054

GO:0030308

GO:0030660

GO:0032277

GO:0034220

GO:0034330

GO:0034634

GO:0034775

GO:0035633

GO:0042908

GO:0043123

GO:0043226

GO:0043231

GO:0044291

GO:0045121

GO:0046849

GO:0048856

GO:0055077

GO:0055085

GO:0060348

GO:0070160

GO:0086014

GO:0086064

GO:0086075

GO:0120162

GO:0140115

GO:1901164

GO:1903763

GO:1904646

GO:1904707

GO:1905332

GO:1905772

GO:2000648

HMNXSV003054192

ILMN_1727087

PH_hs_0028961

TC06000945.hg

U64573_s_at

X52947_at

g4755136_3p_at

Participates

as a component of

Connexin 43 connexon in Golgi transport vesicle [Golgi-associated vesicle membrane] (Homo sapiens)

Other forms of this molecule

GJA1 [plasma membrane]

p-Y265-GJA1 [plasma membrane]

GJA1 [lysosomal membrane]

GJA1 [endoplasmic reticulum membrane]

GJA1 [Golgi membrane]

p-S373-GJA1 [plasma membrane]

Inferred To

CXNK1 [Golgi-associated vesicle membrane] (Canis familiaris)

GJA1 [Golgi-associated vesicle membrane] (Bos taurus)

GJA1 [Golgi-associated vesicle membrane] (Gallus gallus)

GJA1 [Golgi-associated vesicle membrane] (Sus scrofa)

gja1 [Golgi-associated vesicle membrane] (Danio rerio)

gja1 [Golgi-associated vesicle membrane] (Xenopus tropicalis)

Gja1 [Golgi-associated vesicle membrane] (Mus musculus)

Gja1 [Golgi-associated vesicle membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_000156.1

Guide to Pharmacology - Targets

728

ENSEMBL

ENST00000282561, ENST00000650427, ENSP00000497367, ENSP00000497565, ENST00000647564, ENSG00000152661, ENSP00000282561, ENSP00000497283, ENST00000649003

OpenTargets

ENSG00000152661

GeneCards

GJA1

HPA

ENSG00000152661-GJA1

PRO

P17302

Pharos - Targets

P17302

Orphanet

GJA1

HMDB Protein

HMDBP01740

PDB

8QKO, 7XQF, 7XQD, 7XQI, 7XQG, 2LL2, 7Z22, 7F92, 7F94, 7XQH, 7XQJ, 7F93, 7Z23, 7Z1T, 7XQ9, 7XQB

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43889-2 CREB3			0.666	4
UniProt:Q07157 TJP1	5	TJP1 [cytosol] (R-HSA-532659) TJP1 [Golgi-associated vesicle membrane] (R-HSA-3209843) TJP1 [plasma membrane] (R-HSA-3209845) TJP1 (?-?) [plasma membrane] (R-HSA-3209844) TJP1 [cell junction] (R-HSA-8936023)	0.646	3
UniProt:Q8IZF4 AGRG5			0.643	3
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3
UniProt:Q9NZG7 NINJ2			0.556	3
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:Q5BJH2-2 TMEM128			0.556	3
UniProt:Q9NP61 ARFGAP3	1	ARFGAP3 [cytosol] (R-HSA-6807740)	0.556	3
UniProt:Q5VZY2 PLPP4	1	PPAPDC1A [plasma membrane] (R-HSA-2029082)	0.556	3
UniProt:Q8TAB5 CA216			0.556	3
UniProt:P08842 STS	3	STS [endoplasmic reticulum lumen] (R-HSA-1614318) OxA-STS [endoplasmic reticulum lumen] (R-HSA-1614333) OxA-STS [endoplasmic reticulum membrane] (R-HSA-1606833)	0.527	2
UniProt:P21589 NT5E	1	NT5E [plasma membrane] (R-HSA-49191)	0.527	2
UniProt:Q29980 MICB	1	MICB [plasma membrane] (R-HSA-198083)	0.527	2
UniProt:O43505 B4GAT1	1	B4GAT1 [Golgi membrane] (R-HSA-916821)	0.527	2
UniProt:P43681 CHRNA4	1	CHRNA4 [plasma membrane] (R-HSA-507836)	0.527	2
UniProt:P46098 HTR3A	1	HTR3A [plasma membrane] (R-HSA-975301)	0.527	2
UniProt:Q8WXA8 HTR3C	1	HTR3C [plasma membrane] (R-HSA-975312)	0.527	2
UniProt:Q401N2 ZACN			0.527	2
UniProt:Q6P5W5 SLC39A4	9	SLC39A4 [plasma membrane] (R-HSA-442399) SLC39A4 1223_1227del [plasma membrane] (R-HSA-5654119) SLC39A4 L549del [plasma membrane] (R-HSA-5654135) SLC39A4 G330D [plasma membrane] (R-HSA-5654117) SLC39A4 P200L [plasma membrane] (R-HSA-5654131) SLC39A4 Q323Qfs*25 [plasma membrane] (R-HSA-5654109) SLC39A4 G512W [plasma membrane] (R-HSA-5654106) SLC39A4 G526R [plasma membrane] (R-HSA-5654120) SLC39A4 R95C [plasma membrane] (R-HSA-5654137)	0.527	2
UniProt:P16444 DPEP1	1	DPEP1 [plasma membrane] (R-HSA-2142820)	0.527	2
UniProt:Q99679 GPR21			0.527	2