Reactome | LAMC2 [extracellular region]

LAMC2 [extracellular region]

Stable Identifier

R-HSA-446012

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Laminin gamma-2 chain

Locations in the PathwayBrowser

Expand all

Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Type I hemidesmosome assembly (Homo sapiens)
    - BP180 interacts extracellularly with Laminin 332 (Homo sapiens)
      - Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
        
        Laminin-332 [extracellular region] (Homo sapiens)
        
        LAMC2 [extracellular region] (Homo sapiens)
      - Laminin-332 [extracellular region] (Homo sapiens)
        
        LAMC2 [extracellular region] (Homo sapiens)
    - BP230 interacts with keretin K5/K14 (Homo sapiens)
      - CD151:BP230:BP180:Plectin:Integrin alpha 6 beta 4: Laminin [plasma membrane] (Homo sapiens)
        
        BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
        
        Laminin-332 [extracellular region] (Homo sapiens)
        
        LAMC2 [extracellular region] (Homo sapiens)
      - Type II hemidesmosome [plasma membrane] (Homo sapiens)
        
        CD151:BP230:BP180:Plectin:Integrin alpha 6 beta 4: Laminin [plasma membrane] (Homo sapiens)
        
        BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
        
        Laminin-332 [extracellular region] (Homo sapiens)
        
        LAMC2 [extracellular region] (Homo sapiens)
    - BP230 is recruited to the hemidesmosome (Homo sapiens)
      - BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
        
        Laminin-332 [extracellular region] (Homo sapiens)
        
        LAMC2 [extracellular region] (Homo sapiens)
      - Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
        
        Laminin-332 [extracellular region] (Homo sapiens)
        
        LAMC2 [extracellular region] (Homo sapiens)
    - CD151 interacts with BP180 and the integrin alpha 6 subunit (Homo sapiens)
      - BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
        
        Laminin-332 [extracellular region] (Homo sapiens)
        
        LAMC2 [extracellular region] (Homo sapiens)
      - CD151:BP230:BP180:Plectin:Integrin alpha 6 beta 4: Laminin [plasma membrane] (Homo sapiens)
        
        BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
        
        Laminin-332 [extracellular region] (Homo sapiens)
        
        LAMC2 [extracellular region] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by MET (Homo sapiens)
    - MET promotes cell motility (Homo sapiens)
      - MET activates PTK2 signaling (Homo sapiens)
        
        PTK2 binds activated MET (Homo sapiens)
        
        Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Homo sapiens)
        
        Collagen, laminin, fibronectin [extracellular region] (Homo sapiens)
        
        Laminins [extracellular region] (Homo sapiens)
        
        Laminin-332 [extracellular region] (Homo sapiens)
        
        LAMC2 [extracellular region] (Homo sapiens)
        
        Laminin-522 [extracellular region] (Homo sapiens)
        
        LAMC2 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13753 LAMC2

Gene Names

LAMC2, LAMB2T, LAMNB2

Chain

signal peptide:1-21, chain:22-1193

Reference Genes

BioGPS Gene:3918 LAMC2

COSMIC (genes):LAMC2 LAMC2

CTD Gene:3918 LAMC2

dbSNP Gene:3918 LAMC2

ENSEMBL:ENSG00000058085 LAMC2

HGNC:6493 LAMC2

KEGG:hsa:3918 LAMC2

Monarch:3918 LAMC2

NCBI Gene:3918 LAMC2

OMIM:150292 LAMC2

UCSC:Q13753 LAMC2

Reference Transcript

Other Identifiers

11737323_at

11737324_x_at

11737325_a_at

11743514_a_at

11743515_s_at

11743516_s_at

11747923_s_at

16674845

202267_PM_at

202267_at

207517_3p_at

207517_PM_at

207517_at

2371145

2371146

2371150

2371152

2371153

2371155

2371157

2371158

2371159

2371160

2371161

2371162

2371164

2371165

2371166

2371167

2371169

2371170

2371171

2371172

2371173

2371174

2371175

2371176

2371177

2371178

2371179

2371180

2371182

2371183

2371184

2371185

2371186

2371187

2371188

2371189

2371190

35280_at

35281_at

3918

7908072

A_14_P121573

A_23_P160968

A_23_P201636

GE60355

GE82450

GO:0005198

GO:0005201

GO:0005576

GO:0005604

GO:0005607

GO:0005615

GO:0005938

GO:0007155

GO:0008201

GO:0008284

GO:0008544

GO:0030312

GO:0030335

GO:0031012

GO:0048471

GO:0048856

GO:0062023

HMNXSV003011006

HMNXSV003011007

ILMN_1653824

ILMN_1701424

ILMN_1706519

PH_hs_0003563

TC01001585.hg

U31201_cds1_at

U31201_cds2_s_at

g5031846_3p_at

g9845499_3p_at

Participates

as a component of

Other forms of this molecule

LAMC2(22-?) [extracellular region]

LAMC2(?-1193) [extracellular region]

Inferred To

Ghost homologue of LAMC2 [extracellular region] (Bos taurus)

Ghost homologue of LAMC2 [extracellular region] (Canis familiaris)

Ghost homologue of LAMC2 [extracellular region] (Mus musculus)

Ghost homologue of LAMC2 [extracellular region] (Rattus norvegicus)

Ghost homologue of LAMC2 [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_061486.2, NP_005553.2

ENSEMBL

ENST00000264144, ENSP00000432063, ENSP00000264144, ENST00000493293

OpenTargets

ENSG00000058085

HPA

ENSG00000058085-LAMC2

PRO

Q13753

Pharos - Targets

Q13753

GlyGen

Q13753

Orphanet

LAMC2

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