PI3K-binding ALK mutants [cytosol]

Stable Identifier
R-HSA-9711929
Type
Set [CandidateSet]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
18923524 Oncogenic mutations of ALK kinase in neuroblastoma

Chen, Y, Takita, J, Choi, YL, Kato, M, Ohira, M, Sanada, M, Wang, L, Soda, M, Kikuchi, A, Igarashi, T, Nakagawara, A, Hayashi, Y, Mano, H, Ogawa, S

Nature 2008
23139213 Characterization of rearrangements involving the ALK gene reveals a novel truncated form associated with tumor aggressiveness in neuroblastoma

Cazes, A, Louis-Brennetot, C, Mazot, P, Dingli, F, Lombard, B, Boeva, V, Daveau, R, Cappo, J, Combaret, V, Schleiermacher, G, Jouannet, S, Ferrand, S, Pierron, G, Barillot, E, Loew, D, Vigny, M, Delattre, O, Janoueix-Lerosey, I

Cancer Res 2013
18923525 Activating mutations in ALK provide a therapeutic target in neuroblastoma

George, RE, Sanda, T, Hanna, M, Fröhling, S, Luther, W, Zhang, J, Ahn, Y, Zhou, W, London, WB, McGrady, P, Xue, L, Zozulya, S, Gregor, VE, Webb, TR, Gray, NS, Gilliland, DG, Diller, L, Greulich, H, Morris, SW, Meyerson, M, Look, AT

Nature 2008
21656749 A novel KIF5B-ALK variant in nonsmall cell lung cancer

Wong, DW, Leung, EL, Wong, SK, Tin, VP, Sihoe, AD, Cheng, LC, Au, JS, Chung, LP, Wong, MP

Cancer 2011
24445538 Kinase fusions are frequent in Spitz tumours and spitzoid melanomas

Wiesner, T, He, J, Yelensky, R, Esteve-Puig, R, Botton, T, Yeh, I, Lipson, D, Otto, G, Brennan, K, Murali, R, Garrido, M, Miller, VA, Ross, JS, Berger, MF, Sparatta, A, Palmedo, G, Cerroni, L, Busam, KJ, Kutzner, H, Cronin, MT, Stephens, PJ, Bastian, BC

Nat Commun 2014
23104988 Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma

Chand, D, Yamazaki, Y, Ruuth, K, Schönherr, C, Martinsson, T, Kogner, P, Attiyeh, EF, Maris, J, Morozova, O, Marra, MA, Ohira, M, Nakagawara, A, Sandström, PE, Palmer, RH, Hallberg, B

Dis Model Mech 2013
11110708 Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway

Bai, RY, Ouyang, T, Miething, C, Morris, SW, Peschel, C, Duyster, J

Blood 2000
18594010 EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer

Koivunen, JP, Mermel, C, Zejnullahu, K, Murphy, C, Lifshits, E, Holmes, AJ, Choi, HG, Kim, J, Chiang, D, Thomas, R, Lee, J, Richards, WG, Sugarbaker, DJ, Ducko, C, Lindeman, N, Marcoux, JP, Engelman, JA, Gray, NS, Lee, C, Meyerson, M, Jänne, PA

Clin Cancer Res 2008
21415216 Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer

Takezawa, K, Okamoto, I, Nishio, K, Jänne, PA, Nakagawa, K

Clin. Cancer Res. 2011
22570254 Identification of anaplastic lymphoma kinase as a potential therapeutic target in ovarian cancer

Ren, H, Tan, ZP, Zhu, X, Crosby, K, Haack, H, Ren, JM, Beausoleil, S, Moritz, A, Innocenti, G, Rush, J, Zhang, Y, Zhou, XM, Gu, TL, Yang, YF, Comb, MJ

Cancer Res 2012
22249260 Aberrant activation of ALK kinase by a novel truncated form ALK protein in neuroblastoma

Okubo, J, Takita, J, Chen, Y, Oki, K, Nishimura, R, Kato, M, Sanada, M, Hiwatari, M, Hayashi, Y, Igarashi, T, Ogawa, S

Oncogene 2012
21494621 Inhibition of anaplastic lymphoma kinase (ALK) activity provides a therapeutic approach for CLTC-ALK-positive human diffuse large B cell lymphomas

Cerchietti, L, Damm-Welk, C, Vater, I, Klapper, W, Harder, L, Pott, C, Yang, SN, Reiter, A, Siebert, R, Melnick, A, Woessmann, W

PLoS One 2011
21596819 Anaplastic thyroid cancers harbor novel oncogenic mutations of the ALK gene

Murugan, AK, Xing, M

Cancer Res. 2011
21838707 Activating ALK mutations found in neuroblastoma are inhibited by Crizotinib and NVP-TAE684

Schönherr, C, Ruuth, K, Yamazaki, Y, Eriksson, T, Christensen, J, Palmer, RH, Hallberg, B

Biochem J 2011
18923523 Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

Janoueix-Lerosey, I, Lequin, D, Brugières, L, Ribeiro, A, de Pontual, L, Combaret, V, Raynal, V, Puisieux, A, Schleiermacher, G, Pierron, G, Valteau-Couanet, D, Frebourg, T, Michon, J, Lyonnet, S, Amiel, J, Delattre, O

Nature 2008
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Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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