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EML4(1-223)-p-7Y ALK(1059-1620) fusion dimer [cytosol]
Stable Identifier
R-HSA-9700018
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
ALK fusions phosphorylate FRS (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
EML4(1-223)-p-7Y ALK(1059-1620) fusion dimer [cytosol] (Homo sapiens)
ALK fusions phosphorylate IRS1 (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
EML4(1-223)-p-7Y ALK(1059-1620) fusion dimer [cytosol] (Homo sapiens)
ALK mutants bind PI3KCA (Homo sapiens)
ALK mutants:PIK3R1 [cytosol] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
EML4(1-223)-p-7Y ALK(1059-1620) fusion dimer [cytosol] (Homo sapiens)
PI3K-binding ALK fusions:PI3K [cytosol] (Homo sapiens)
ALK mutants:PIK3R1 [cytosol] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
EML4(1-223)-p-7Y ALK(1059-1620) fusion dimer [cytosol] (Homo sapiens)
ALK mutants bind PI3KR1 (Homo sapiens)
ALK mutants:PIK3R1 [cytosol] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
EML4(1-223)-p-7Y ALK(1059-1620) fusion dimer [cytosol] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
EML4(1-223)-p-7Y ALK(1059-1620) fusion dimer [cytosol] (Homo sapiens)
ALK mutants bind STAT3 (Homo sapiens)
STAT3-activating ALK mutants [cytosol] (Homo sapiens)
EML4(1-223)-p-7Y ALK(1059-1620) fusion dimer [cytosol] (Homo sapiens)
STAT3-activating ALK mutants:STAT3 [cytosol] (Homo sapiens)
STAT3-activating ALK mutants [cytosol] (Homo sapiens)
EML4(1-223)-p-7Y ALK(1059-1620) fusion dimer [cytosol] (Homo sapiens)
ALK mutants phosphorylate STAT3 (Homo sapiens)
STAT3-activating ALK mutants [cytosol] (Homo sapiens)
EML4(1-223)-p-7Y ALK(1059-1620) fusion dimer [cytosol] (Homo sapiens)
STAT3-activating ALK mutants:STAT3 [cytosol] (Homo sapiens)
STAT3-activating ALK mutants [cytosol] (Homo sapiens)
EML4(1-223)-p-7Y ALK(1059-1620) fusion dimer [cytosol] (Homo sapiens)
STAT3-activating ALK mutants:p-Y STAT3 [cytosol] (Homo sapiens)
STAT3-activating ALK mutants [cytosol] (Homo sapiens)
EML4(1-223)-p-7Y ALK(1059-1620) fusion dimer [cytosol] (Homo sapiens)
Autophosphorylation of ALK fusions (Homo sapiens)
p-7Y ALK fusion protein dimers [cytosol] (Homo sapiens)
EML4(1-223)-p-7Y ALK(1059-1620) fusion dimer [cytosol] (Homo sapiens)
PI3K synthesizes PIP3 downstream of ALK mutants (Homo sapiens)
PI3K-binding ALK fusions:PI3K [cytosol] (Homo sapiens)
ALK mutants:PIK3R1 [cytosol] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
EML4(1-223)-p-7Y ALK(1059-1620) fusion dimer [cytosol] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
EML4(1-223)-p-7Y ALK(1059-1620) fusion dimer [cytosol] (Homo sapiens)
pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants (Homo sapiens)
STAT3-activating ALK mutants:p-Y STAT3 [cytosol] (Homo sapiens)
STAT3-activating ALK mutants [cytosol] (Homo sapiens)
EML4(1-223)-p-7Y ALK(1059-1620) fusion dimer [cytosol] (Homo sapiens)
Participants
components
x 2
EML4(1-223)-p-7Y-ALK(1059-1620) fusion [cytosol]
(Homo sapiens)
Participates
as a member of
STAT3-activating ALK mutants [cytosol] (Homo sapiens)
p-7Y ALK fusion protein dimers [cytosol] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
Disease
Name
Identifier
Synonyms
non-small cell lung carcinoma
DOID:3908
Non-small cell lung cancer (disorder), NSCLC, NSCLC
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