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FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane]
Stable Identifier
R-HSA-9713501
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
ALK fusions phosphorylate FRS (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] (Homo sapiens)
ALK fusions phosphorylate IRS1 (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] (Homo sapiens)
ALK mutants bind PI3KCA (Homo sapiens)
ALK mutants:PIK3R1 [cytosol] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] (Homo sapiens)
PI3K-binding ALK fusions:PI3K [cytosol] (Homo sapiens)
ALK mutants:PIK3R1 [cytosol] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] (Homo sapiens)
ALK mutants bind PI3KR1 (Homo sapiens)
ALK mutants:PIK3R1 [cytosol] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] (Homo sapiens)
ALK mutants bind SHC (Homo sapiens)
ALK mutant dimers:SHC1 [cytosol] (Homo sapiens)
SHC-binding ALK mutant dimers [cytosol] (Homo sapiens)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] (Homo sapiens)
SHC-binding ALK mutant dimers [cytosol] (Homo sapiens)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] (Homo sapiens)
ALK mutants bind STAT3 (Homo sapiens)
STAT3-activating ALK mutants [cytosol] (Homo sapiens)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] (Homo sapiens)
STAT3-activating ALK mutants:STAT3 [cytosol] (Homo sapiens)
STAT3-activating ALK mutants [cytosol] (Homo sapiens)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] (Homo sapiens)
ALK mutants phosphorylate SHC1 (Homo sapiens)
ALK fusion dimers:p-3Y SHC1 [cytosol] (Homo sapiens)
SHC-binding ALK mutant dimers [cytosol] (Homo sapiens)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] (Homo sapiens)
ALK mutant dimers:SHC1 [cytosol] (Homo sapiens)
SHC-binding ALK mutant dimers [cytosol] (Homo sapiens)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] (Homo sapiens)
ALK mutants phosphorylate STAT3 (Homo sapiens)
STAT3-activating ALK mutants [cytosol] (Homo sapiens)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] (Homo sapiens)
STAT3-activating ALK mutants:STAT3 [cytosol] (Homo sapiens)
STAT3-activating ALK mutants [cytosol] (Homo sapiens)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] (Homo sapiens)
STAT3-activating ALK mutants:p-Y STAT3 [cytosol] (Homo sapiens)
STAT3-activating ALK mutants [cytosol] (Homo sapiens)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] (Homo sapiens)
ALK mutants:p-3Y SHC binds GRB2 (Homo sapiens)
ALK fusion dimers:p-3Y SHC1 [cytosol] (Homo sapiens)
SHC-binding ALK mutant dimers [cytosol] (Homo sapiens)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] (Homo sapiens)
ALK fusion dimers:p-3Y SHC1:GRB2 [cytosol] (Homo sapiens)
SHC-binding ALK mutant dimers [cytosol] (Homo sapiens)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] (Homo sapiens)
Autophosphorylation of ALK fusions (Homo sapiens)
p-7Y ALK fusion protein dimers [cytosol] (Homo sapiens)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] (Homo sapiens)
PI3K synthesizes PIP3 downstream of ALK mutants (Homo sapiens)
PI3K-binding ALK fusions:PI3K [cytosol] (Homo sapiens)
ALK mutants:PIK3R1 [cytosol] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] (Homo sapiens)
pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants (Homo sapiens)
STAT3-activating ALK mutants:p-Y STAT3 [cytosol] (Homo sapiens)
STAT3-activating ALK mutants [cytosol] (Homo sapiens)
FN1(32-1201)-p-7Y ALK(1022-1620) fusion dimer [plasma membrane] (Homo sapiens)
Participants
components
x 2
FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane]
(Homo sapiens)
Participates
as a member of
SHC-binding ALK mutant dimers [cytosol] (Homo sapiens)
STAT3-activating ALK mutants [cytosol] (Homo sapiens)
p-7Y ALK fusion protein dimers [cytosol] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
Disease
Name
Identifier
Synonyms
ovarian carcinoma
DOID:4001
Ovarian carcinoma
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