Regulation of HMOX1 expression and activity

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R-HSA-9707587
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Pathway
Species
Homo sapiens
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Heme oxygenase 1 (HMOX1) is regulated at the level of gene transcription, mRNA translation, localization and degradation. Its gene is often activated under a wide range of stressful conditions. The transcriptional control of HMOX1 is determined by inducible regulatory elements localized in the 5′ region of the promoter, so called antioxidant response elements (ARE)(Raghunath et al, 2018).

AREs on the HMOX1 gene are ultimately controlled by the enhancing NFE2L2:MAFK dimer and the repressing BACH1:MAFK dimer, both of which are influenced by a multitude of processes. Less specific enhancement occurs via AP-1 (FOS:JUN) dimers (Funes et al, 2020).

HMOX1 activity depends on dimerization in the ER membrane. Its membrane localization is abandoned by cleavage of the membrane domain by HM13. The resulting soluble enzyme is found in the cytosol, mitochondria, and the nucleus (Schaefer et al, 2017).

Literature References
PubMed ID Title Journal Year
29155886 Insights into the mechanism of isoenzyme-specific signal peptide peptidase-mediated translocation of heme oxygenase

Schaefer, B, Moriishi, K, Behrends, S

PLoS One 2017
29775961 Antioxidant response elements: Discovery, classes, regulation and potential applications

Raghunath, A, Sundarraj, K, Nagarajan, R, Arfuso, F, Bian, J, Kumar, AP, Sethi, G, Perumal, E

Redox Biol 2018
32849503 Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases

Funes, SC, Rios, M, Fernández-Fierro, A, Covián, C, Bueno, SM, Riedel, CA, Mackern-Oberti, JP, Kalergis, AM

Front Immunol 2020
16601269 Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications

Ryter, SW, Alam, J, Choi, AM

Physiol Rev 2006
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