Reactome | Regulation of HMOX1 expression and activity

Regulation of HMOX1 expression and activity

Stable Identifier

R-HSA-9707587

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Regulation of HMOX1 expression and activity

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Heme oxygenase 1 (HMOX1) is regulated at the level of gene transcription, mRNA translation, localization and degradation. Its gene is often activated under a wide range of stressful conditions. The transcriptional control of HMOX1 is determined by inducible regulatory elements localized in the 5′ region of the promoter, so called antioxidant response elements (ARE)(Raghunath et al, 2018).

AREs on the HMOX1 gene are ultimately controlled by the enhancing NFE2L2:MAFK dimer and the repressing BACH1:MAFK dimer, both of which are influenced by a multitude of processes. Less specific enhancement occurs via AP-1 (FOS:JUN) dimers (Funes et al, 2020).

HMOX1 activity depends on dimerization in the ER membrane. Its membrane localization is abandoned by cleavage of the membrane domain by HM13. The resulting soluble enzyme is found in the cytosol, mitochondria, and the nucleus (Schaefer et al, 2017).

Literature References

PubMed ID	Title	Journal	Year
29775961	Antioxidant response elements: Discovery, classes, regulation and potential applications Raghunath, A, Sundarraj, K, Nagarajan, R, Arfuso, F, Bian, J, Kumar, AP, Sethi, G, Perumal, E	Redox Biol	2018
29155886	Insights into the mechanism of isoenzyme-specific signal peptide peptidase-mediated translocation of heme oxygenase Schaefer, B, Moriishi, K, Behrends, S	PLoS One	2017
32849503	Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases Funes, SC, Rios, M, Fernández-Fierro, A, Covián, C, Bueno, SM, Riedel, CA, Mackern-Oberti, JP, Kalergis, AM	Front Immunol	2020
16601269	Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications Ryter, SW, Alam, J, Choi, AM	Physiol Rev	2006