Cleavage of heme oxygenase 1 (HMOX1) by HM13 (Signal peptide peptidase) takes place in the ER membrane and removes the membrane domain from HMOX1, making it soluble in the cytosol. The reaction only occurs under conditions of hypoxia (Schaefer et al, 2017; Boname et al, 2014).
Smith, DL, Smith, JC, Nathan, JA, Wandel, MP, Thurston, TL, Bloor, S, Dingwell, KS, Lehner, PJ, Randow, F, Boname, JM, Antrobus, R
Behrends, S, Schaefer, B, Moriishi, K
aspartic endopeptidase activity, intramembrane cleaving of HM13 [endoplasmic reticulum membrane]
© 2022 Reactome