HM13 cleaves HMOX1 dimer

Stable Identifier
R-HSA-9708457
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cleavage of heme oxygenase 1 (HMOX1) by HM13 (Signal peptide peptidase) takes place in the ER membrane and removes the membrane domain from HMOX1, making it soluble in the cytosol. The reaction only occurs under conditions of hypoxia (Schaefer et al, 2017; Boname et al, 2014).

Literature References
PubMed ID Title Journal Year
29155886 Insights into the mechanism of isoenzyme-specific signal peptide peptidase-mediated translocation of heme oxygenase

Schaefer, B, Moriishi, K, Behrends, S

PLoS One 2017
24958774 Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins

Boname, JM, Bloor, S, Wandel, MP, Nathan, JA, Antrobus, R, Dingwell, KS, Thurston, TL, Smith, DL, Smith, JC, Randow, F, Lehner, PJ

J Cell Biol 2014
Participants
Participates
Catalyst Activity

aspartic endopeptidase activity, intramembrane cleaving of HM13 [endoplasmic reticulum membrane]

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