HM13 cleaves HMOX1 dimer

Stable Identifier
R-HSA-9708457
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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HM13 cleaves HMOX1 dimer
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Cleavage of heme oxygenase 1 (HMOX1) by HM13 (Signal peptide peptidase) takes place in the ER membrane and removes the membrane domain from HMOX1, making it soluble in the cytosol. The reaction only occurs under conditions of hypoxia (Schaefer et al, 2017; Boname et al, 2014).
Literature References
PubMed ID Title Journal Year
24958774 Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins

Smith, DL, Smith, JC, Nathan, JA, Wandel, MP, Thurston, TL, Bloor, S, Dingwell, KS, Lehner, PJ, Randow, F, Boname, JM, Antrobus, R

J Cell Biol 2014
29155886 Insights into the mechanism of isoenzyme-specific signal peptide peptidase-mediated translocation of heme oxygenase

Behrends, S, Schaefer, B, Moriishi, K

PLoS One 2017
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Output
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as an event of
Catalyst Activity

aspartic endopeptidase activity, intramembrane cleaving of HM13 [endoplasmic reticulum membrane]

Physical Entity
HM13 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
aspartic endopeptidase activity, intramembrane cleaving (GO:0042500)
Orthologous Events
HM13 cleaves HMOX1 dimer (Bos taurus)
HM13 cleaves HMOX1 dimer (Canis familiaris)
HM13 cleaves HMOX1 dimer (Drosophila melanogaster)
HM13 cleaves HMOX1 dimer (Gallus gallus)
HM13 cleaves HMOX1 dimer (Mus musculus)
HM13 cleaves HMOX1 dimer (Rattus norvegicus)
HM13 cleaves HMOX1 dimer (Sus scrofa)
Authored
Stephan, R  (2020-11-23)
Reviewed
Somers, J  (2021-01-23)
Created
Stephan, R  (2020-11-30)
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