Transcription regulator protein BACH1 is a critical physiological repressor of heme oxygenase 1 (HMOX1). BACH1 binds to the multiple Maf recognition elements (MAREs) of HMOX1 enhancer MafK in vitro and represses its activity in vivo. BACH1 is inducible by hypoxia and IFN-gamma (Kitamuro et al, 2003; Sun et al, 2002).NFE2L2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that activates transcription of a battery of cytoprotective genes by binding to the ARE (antioxidant response element). It is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. HMOX1 is one of the genes whose expression it activates (Huang et al, 2000; Reichard et al, 2007).
Kitamuro, T, Takahashi, K, Ogawa, K, Udono-Fujimori, R, Takeda, K, Furuyama, K, Nakayama, M, Sun, J, Fujita, H, Hida, W, Hattori, T, Shirato, K, Igarashi, K, Shibahara, S
Sun, J, Hoshino, H, Takaku, K, Nakajima, O, Muto, A, Suzuki, H, Tashiro, S, Takahashi, S, Shibahara, S, Alam, J, Taketo, MM, Yamamoto, M, Igarashi, K
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