HMOX1 gene produces HMOX1 dimer

Stable Identifier
R-HSA-9707645
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm, endoplasmic reticulum membrane
Synonyms
HMOX1 expression is repressed by BACH1:MAFK
ReviewStatus
5/5
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HMOX1 gene produces HMOX1 dimer
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Transcription regulator protein BACH1 is a critical physiological repressor of heme oxygenase 1 (HMOX1). BACH1 binds to the multiple Maf recognition elements (MAREs) of HMOX1 enhancer MafK in vitro and represses its activity in vivo. BACH1 is inducible by hypoxia and IFN-gamma (Kitamuro et al, 2003; Sun et al, 2002).

NFE2L2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that activates transcription of a battery of cytoprotective genes by binding to the ARE (antioxidant response element). It is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. HMOX1 is one of the genes whose expression it activates (Huang et al, 2000; Reichard et al, 2007).
Literature References
PubMed ID Title Journal Year
12356737 Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene

Sun, J, Muto, A, Takaku, K, Suzuki, H, Takahashi, S, Taketo, MM, Shibahara, S, Alam, J, Yamamoto, M, Igarashi, K, Hoshino, H, Tashiro, S, Nakajima, O

EMBO J 2002
12511571 Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells

Sun, J, Takeda, K, Shirato, K, Nakayama, M, Shibahara, S, Fujita, H, Udono-Fujimori, R, Igarashi, K, Ogawa, K, Kitamuro, T, Hattori, T, Furuyama, K, Takahashi, K, Hida, W

J Biol Chem 2003
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
BACH1:MAFK [nucleoplasm] (Homo sapiens)
Positively by
Regulator
p-NFE2L2:MAFK [nucleoplasm] (Homo sapiens)
Authored
Stephan, R  (2020-11-12)
Reviewed
Somers, J  (2021-01-23)
Cuadrado, A  (2022-02-23)
Created
Stephan, R  (2020-11-19)
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