HMOX1 translocates from the cytosol to the nucleoplasm

Stable Identifier
R-HSA-9708536
Type
Reaction [uncertain]
Species
Homo sapiens
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Synonyms
HMOX1 localizes to the nucleus
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After exposure to hypoxia and heme or heme/hemopexin, soluble heme oxygenase 1 (HMOX1) is detected in the nucleus. Nuclear localization is also associated with reduction of HMOX1 activity. HMOX1 protein, whether it s enzymatically active or not, mediates activation of oxidant-responsive transcription factors, including activator protein-1 (AP-1). Nevertheless, nuclear HMOX1 protects cells against hydrogen peroxide-mediated injury equally as well as cytoplasmic HMOX1 (Lin et al, 2007).

Literature References
PubMed ID Title Journal Year
17430897 Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress

Lin, Q, Weis, S, Yang, G, Weng, YH, Helston, R, Rish, K, Smith, A, Bordner, J, Polte, T, Gaunitz, F, Dennery, PA

J Biol Chem 2007
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