After exposure to hypoxia and heme or heme/hemopexin, soluble heme oxygenase 1 (HMOX1) is detected in the nucleus. Nuclear localization is also associated with reduction of HMOX1 activity. HMOX1 protein, whether it s enzymatically active or not, mediates activation of oxidant-responsive transcription factors, including activator protein-1 (AP-1). Nevertheless, nuclear HMOX1 protects cells against hydrogen peroxide-mediated injury equally as well as cytoplasmic HMOX1 (Lin et al, 2007).
Lin, Q, Weis, S, Yang, G, Weng, YH, Helston, R, Rish, K, Smith, A, Bordner, J, Polte, T, Gaunitz, F, Dennery, PA
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