HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane

Stable Identifier
R-HSA-9708558
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
HMOX1 localizes to the mitochondrion
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Heme oxygenase 1 (HMOX1) expression increases dramatically in cytosolic and mitochondrial fractions of human alveolar (A549), or bronchial epithelial cells (Beas-2b) exposed to either heme, lipopolysaccharide, or cigarette smoke extract (CSE). Mitochondrial localization of HMOX1 is also observed in a primary culture of human small airway epithelial cells (Siebos et al, 2007).

Literature References
PubMed ID Title Journal Year
17079780 Mitochondrial localization and function of heme oxygenase-1 in cigarette smoke-induced cell death

Slebos, DJ, Ryter, SW, van der Toorn, M, Liu, F, Guo, F, Baty, CJ, Karlsson, JM, Watkins, SC, Kim, HP, Wang, X, Lee, JS, Postma, DS, Kauffman, HF, Choi, AM

Am J Respir Cell Mol Biol 2007
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