Negative regulation of FLT3

Stable Identifier
R-HSA-9706369
Type
Pathway
Species
Homo sapiens
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Negative regulation of FLT3
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FLT3 activity is negatively regulated through several mechanisms including dephosphorylation, interaction with protein partners that limit downstream signaling pathways, and by ubiquitin-mediated internalization and degradation (reviewed in Kazi and Roonstrand, 2019).

Literature References
PubMed ID Title Journal Year
31066629 FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

Kazi, JU, Rönnstrand, L

Physiol. Rev. 2019
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Orthologous Events
Negative regulation of FLT3 (Bos taurus)
Negative regulation of FLT3 (Canis familiaris)
Negative regulation of FLT3 (Mus musculus)
Negative regulation of FLT3 (Rattus norvegicus)
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-11-04)
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