Negative regulation of FLT3

Stable Identifier
R-HSA-9706369
Type
Pathway
Species
Homo sapiens
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Negative regulation of FLT3
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FLT3 activity is negatively regulated through several mechanisms including dephosphorylation, interaction with protein partners that limit downstream signaling pathways, and by ubiquitin-mediated internalization and degradation (reviewed in Kazi and Roonstrand, 2019).

Literature References
PubMed ID Title Journal Year
31066629 FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

Kazi, JU, Rönnstrand, L

Physiol. Rev. 2019
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Orthologous Events
Negative regulation of FLT3 (Bos taurus)
Negative regulation of FLT3 (Canis familiaris)
Negative regulation of FLT3 (Mus musculus)
Negative regulation of FLT3 (Rattus norvegicus)
Negative regulation of FLT3 (Sus scrofa)
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-11-04)
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