PTN and MDK bind to PTPRZ

Stable Identifier
Homo sapiens
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MDK and PTN each bind PTPRZ through the chondroitin sulphate modification on the phosphatase (Maeda et al, 1999; Kuboyama et al, 2016; Ryan et al, 2016). MDK- or PTN-binding promotes oligomerization of the enzyme, inhibiting its catalytic activity (Fukada et al, 2006). Binding of PTN and MDK to PTPRZ therefore results in increased ALK tyrosine phosphorylation and downstream signaling (reviewed in Deuel, 2013; Della Corte et al, 2018).

Literature References
PubMed ID Title Journal Year
16814777 Protein tyrosine phosphatase receptor type Z is inactivated by ligand-induced oligomerization

Chow, JP, Fukada, M, Ikematsu, S, Sakuma, S, Fujikawa, A, Noda, M

FEBS Lett. 2006
29455642 Role and targeting of anaplastic lymphoma kinase in cancer

Troiani, T, Viscardi, G, Morgillo, F, Fasano, M, Martinelli, E, Ciardiello, F, Della Corte, CM, Di Liello, R

Mol. Cancer 2018
10212223 A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta

Maeda, N, Noda, M, Ichihara-Tanaka, K, Kadomatsu, K, Muramatsu, T, Kimura, T

J. Biol. Chem. 1999
27445335 Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION

Tanga, N, Kuboyama, K, Suzuki, R, Fujikawa, A, Noda, M

J. Biol. Chem. 2016
23777859 Anaplastic lymphoma kinase: "Ligand Independent Activation" mediated by the PTN/RPTPβ/ζ signaling pathway

Deuel, TF

Biochim. Biophys. Acta 2013
26896299 Structural studies reveal an important role for the pleiotrophin C-terminus in mediating interactions with chondroitin sulfate

Ryan, E, Shen, D, Wang, X

FEBS J. 2016
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