MDK and PTN each bind PTPRZ through the chondroitin sulphate modification on the phosphatase (Maeda et al, 1999; Kuboyama et al, 2016; Ryan et al, 2016). MDK- or PTN-binding promotes oligomerization of the enzyme, inhibiting its catalytic activity (Fukada et al, 2006). Binding of PTN and MDK to PTPRZ therefore results in increased ALK tyrosine phosphorylation and downstream signaling (reviewed in Deuel, 2013; Della Corte et al, 2018).
Chow, JP, Fukada, M, Ikematsu, S, Sakuma, S, Fujikawa, A, Noda, M
Troiani, T, Viscardi, G, Morgillo, F, Fasano, M, Martinelli, E, Ciardiello, F, Della Corte, CM, Di Liello, R
Maeda, N, Noda, M, Ichihara-Tanaka, K, Kadomatsu, K, Muramatsu, T, Kimura, T
Tanga, N, Kuboyama, K, Suzuki, R, Fujikawa, A, Noda, M
Deuel, TF
Ryan, E, Shen, D, Wang, X
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