Reactome | PTN and MDK bind to PTPRZ

PTN and MDK bind to PTPRZ

Stable Identifier

R-HSA-9700120

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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MDK and PTN each bind PTPRZ through the chondroitin sulphate modification on the phosphatase (Maeda et al, 1999; Kuboyama et al, 2016; Ryan et al, 2016). MDK- or PTN-binding promotes oligomerization of the enzyme, inhibiting its catalytic activity (Fukada et al, 2006). Binding of PTN and MDK to PTPRZ therefore results in increased ALK tyrosine phosphorylation and downstream signaling (reviewed in Deuel, 2013; Della Corte et al, 2018).

Literature References

PubMed ID	Title	Journal	Year
16814777	Protein tyrosine phosphatase receptor type Z is inactivated by ligand-induced oligomerization Fukada, M, Fujikawa, A, Chow, JP, Ikematsu, S, Sakuma, S, Noda, M	FEBS Lett.	2006
29455642	Role and targeting of anaplastic lymphoma kinase in cancer Della Corte, CM, Viscardi, G, Di Liello, R, Fasano, M, Martinelli, E, Troiani, T, Ciardiello, F, Morgillo, F	Mol. Cancer	2018
10212223	A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta Maeda, N, Ichihara-Tanaka, K, Kimura, T, Kadomatsu, K, Muramatsu, T, Noda, M	J. Biol. Chem.	1999
27445335	Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION Kuboyama, K, Fujikawa, A, Suzuki, R, Tanga, N, Noda, M	J. Biol. Chem.	2016
23777859	Anaplastic lymphoma kinase: "Ligand Independent Activation" mediated by the PTN/RPTPβ/ζ signaling pathway Deuel, TF	Biochim. Biophys. Acta	2013
26896299	Structural studies reveal an important role for the pleiotrophin C-terminus in mediating interactions with chondroitin sulfate Ryan, E, Shen, D, Wang, X	FEBS J.	2016