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Microbial modulation of RIPK1-mediated regulated necrosis
Stable Identifier
R-HSA-9686347
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective RIPK1-mediated regulated necrosis (Homo sapiens)
Microbial modulation of RIPK1-mediated regulated necrosis (Homo sapiens)
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Activation of receptor-interacting serine/threonine protein (RIP) kinases RIPK1 and RIPK3 coordinate an immunogenic form of programmed cell death known as regulated necrosis or necroptosis (Upton JW et al. 2017). This form of necrosis leads to anti-viral inflammation in host through cell death-associated release of damage-associated molecular patterns (DAMPs) (Nailwal H & Ka-Ming Chan F 2019; Upton JW et al. 2017). Microbial pathogens are able to modulate host regulated necrosis through different triggers and pathways. The promotion and inhibition of host cell death vary and depend on the microbe types, virulence, and phenotypes (Upton JW et al. 2010, 2012, 2017; Jaclyn S Pearson JS et al. 2017; Petrie EJ et al. 2019; Fletcher-Etherington A et al. 2020; Nailwal H & Ka-Ming Chan F 2019; ).
Participants
Events
SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer
(Homo sapiens)
SARS-CoV-1 3a oligomerizes
(Homo sapiens)
SARS-CoV-1 3a binds the lysosomal membrane
(Homo sapiens)
IAV NS1 binds MLKL
(Homo sapiens)
HSV1 RIR1 binds RIPK1
(Homo sapiens)
HSV1 RIR1 binds RIPK3
(Homo sapiens)
HSV1 RIR1 binds CASP8
(Homo sapiens)
Viral serpin blocks caspase-8 activity
(Homo sapiens)
HCMV UL36 binds MLKL
(Homo sapiens)
Participates
as an event of
Defective RIPK1-mediated regulated necrosis (Homo sapiens)
Disease
Name
Identifier
Synonyms
bacterial infectious disease
DOID:104
viral infectious disease
DOID:934
Viral disease, virus infection, virus infection
Cross References
BioModels Database
BIOMD0000000407
Authored
Shamovsky, V (2020-05-21)
Reviewed
Murphy, JM (2020-08-28)
D'Eustachio, P (2020-06-26)
Created
Shamovsky, V (2020-04-30)
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