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Defective RIPK1-mediated regulated necrosis
Stable Identifier
R-HSA-9693928
DOI
10.3180/R-HSA-9693928.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective RIPK1-mediated regulated necrosis (Homo sapiens)
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Receptor Interacting Serine/Threonine Kinase 1 (RIPK1)-mediated regulated necrosis also called necroptosis is an important type of programmed cell death in addition to apoptosis. Necroptosis eventually leads to cell lysis and release of cytoplasmic content into the extracellular region. Necroptosis must be tightly controlled. Disregulated or defective necroptotic cell death is often associated with a tissue damage resulting in an intense inflammatory response. Defects of necroptosis may contribute to various pathological processes, including autoimmune disease, neurodegeneration, multiple cancers, and kidney injury.
Literature References
PubMed ID
Title
Journal
Year
29593066
Necroptosis in development and diseases
Najafov, A
,
Shan, B
,
Yuan, J
,
Pan, H
Genes Dev.
2018
Participants
Events
RIPK1 variant is not cleaved by CASP8
(Homo sapiens)
Microbial modulation of RIPK1-mediated regulated necrosis
(Homo sapiens)
Participates
as an event of
Diseases of programmed cell death (Homo sapiens)
Disease
Name
Identifier
Synonyms
genetic disease
DOID:630
Cross References
BioModels Database
BIOMD0000000407
Authored
Shamovsky, V (2020-07-08)
Reviewed
Lalaoui, N (2020-08-20)
D'Eustachio, P (2020-06-26)
Created
Shamovsky, V (2020-07-08)
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