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SERPING1 [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-9650418
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
C1Inh, plasma protease C1 inhibitor, C1-In
Icon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Intrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
SERPING1 is secreted (Homo sapiens)
SERPING1 [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P05155 SERPING1
Gene Names
SERPING1, C1IN, C1NH
Chain
signal peptide:1-22, chain:23-500
Reference Genes
BioGPS Gene:710 SERPING1
COSMIC (genes):SERPING1 SERPING1
CTD Gene:710 SERPING1
dbSNP Gene:710 SERPING1
ENSEMBL:ENSG00000149131 SERPING1
ENSEMBL_homo_sapiens_GENE:ENSG00000149131.17 SERPING1
HGNC:1228 SERPING1
KEGG Gene (Homo sapiens):710 SERPING1
Monarch:710 SERPING1
NCBI Gene:710 SERPING1
OMIM:606860 SERPING1
UCSC:P05155 SERPING1
Reference Transcript
RefSeq:NM_001032295.1 SERPING1
RefSeq:NM_000062.2 SERPING1
Other Identifiers
11715368_a_at
11751845_x_at
16724861
200986_PM_at
200986_at
3331358
3331359
3331360
3331362
3331363
3331364
3331365
3331366
3331369
3331372
3331373
3331376
3331379
3331380
39775_at
710
7940028
A_14_P105872
A_23_P139123
A_33_P3413987
A_33_P3413989
GE61906
GO:0001869
GO:0002376
GO:0003013
GO:0004867
GO:0005515
GO:0005576
GO:0005615
GO:0005783
GO:0005788
GO:0006958
GO:0007596
GO:0007599
GO:0008015
GO:0030312
GO:0030414
GO:0031012
GO:0031093
GO:0031410
GO:0042060
GO:0042730
GO:0043226
GO:0045087
GO:0062023
GO:0070062
GO:0072562
GO:0098542
GO:0098772
HMNXSV003008886
ILMN_1670305
ILMN_1711272
M13690_s_at
PH_hs_0018714
TC11000467.hg
TC11002677.hg
g4557378_3p_at
Participates
as an input of
SERPING1 is secreted (Homo sapiens)
Other forms of this molecule
SERPING1 [platelet alpha granule lumen]
SERPING1 L177P [endoplasmic reticulum lumen]
SERPING1 R400C [endoplasmic reticulum lumen]
SERPING1 V288E [endoplasmic reticulum lumen]
SERPING1 G184_P228del [endoplasmic reticulum lumen]
SERPING1 F236S [endoplasmic reticulum lumen]
SERPING1 T189N [endoplasmic reticulum lumen]
SERPING1 P476L [endoplasmic reticulum lumen]
SERPING1 G184R [endoplasmic reticulum lumen]
SERPING1 P489R [endoplasmic reticulum lumen]
SERPING1 S170P [endoplasmic reticulum lumen]
SERPING1 S280_P282del [endoplasmic reticulum lumen]
SERPING1 V473M [endoplasmic reticulum lumen]
SERPING1 N291H [endoplasmic reticulum lumen]
SERPING1 Q484* [endoplasmic reticulum lumen]
SERPING1 A2_M53del [endoplasmic reticulum lumen]
SERPING1 W482* [endoplasmic reticulum lumen]
SERPING1 Q338* [endoplasmic reticulum lumen]
SERPING1 I196N [endoplasmic reticulum lumen]
SERPING1 S36Ffs*21 [endoplasmic reticulum lumen]
SERPING1 G184E [endoplasmic reticulum lumen]
SERPING1 L481P [endoplasmic reticulum lumen]
SERPING1 G345R [endoplasmic reticulum lumen]
SERPING1 L481R [endoplasmic reticulum lumen]
SERPING1 S318* [endoplasmic reticulum lumen]
SERPING1 R494* [endoplasmic reticulum lumen]
SERPING1 G493E [endoplasmic reticulum lumen]
SERPING1 F225* [endoplasmic reticulum lumen]
SERPING1 P498R [endoplasmic reticulum lumen]
SERPING1 Y496* [endoplasmic reticulum lumen]
SERPING1 Q474* [endoplasmic reticulum lumen]
SERPING1 R466S [extracellular region]
SERPING1 I462S [extracellular region]
SERPING1 P498S [extracellular region]
SERPING1 A456E [extracellular region]
SERPING1 R466C [extracellular region]
SERPING1 A458T [extracellular region]
SERPING1 R466L [extracellular region]
SERPING1 R466H [extracellular region]
SERPING1 [extracellular region]
SERPING1 T467P [extracellular region]
SERPING1 G493R [extracellular region]
SERPING1 L273del [extracellular region]
SERPING1 D84_T138del [extracellular region]
SERPING1 A458V [extracellular region]
Inferred To
SERPING1 [endoplasmic reticulum lumen]
(Bos taurus)
SERPING1 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
SERPING1 [endoplasmic reticulum lumen]
(Canis familiaris)
SERPING1 [endoplasmic reticulum lumen]
(Gallus gallus)
SERPING1 [endoplasmic reticulum lumen]
(Sus scrofa)
Spn75F [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Spn88Ea [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Spn42Dc [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Spn55B [endoplasmic reticulum lumen]
(Drosophila melanogaster)
nec [endoplasmic reticulum lumen]
(Drosophila melanogaster)
srp-2 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
Spn43Ab [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Spn42Db [endoplasmic reticulum lumen]
(Drosophila melanogaster)
srp-3 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
Spn53F [endoplasmic reticulum lumen]
(Drosophila melanogaster)
srp-8 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
Serping1 [endoplasmic reticulum lumen]
(Mus musculus)
Serping1 [endoplasmic reticulum lumen]
(Rattus norvegicus)
Spn42De [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Homologues of SERPING1 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
Homologues of SERPING1 [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Spn100A [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Spn28F [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Spn43Aa [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Spn43Ad [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Spn42Dd [endoplasmic reticulum lumen]
(Drosophila melanogaster)
srp-1 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
Spn31A [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Spn38F [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Spn28B [endoplasmic reticulum lumen]
(Drosophila melanogaster)
srp-6 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
Spn28Da [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Dmel\CG43366 [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Spn27A [endoplasmic reticulum lumen]
(Drosophila melanogaster)
srp-7 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
Acp76A [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Spn42Da [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Spn28Db [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Spn85F [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Spn47C [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Spn88Eb [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001027466.1
,
NP_000053.2
OpenTargets
ENSG00000149131
HPA
ENSG00000149131-SERPING1
GeneCards
P05155
Ensembl
ENST00000378324
,
ENST00000378323
,
ENSP00000278407
,
ENST00000676670
,
ENSP00000504807
,
ENSP00000367575
,
ENSG00000149131
,
ENST00000278407
,
ENSP00000367574
PRO
P05155
Pharos - Targets
P05155
Orphanet
15274
PDB
5DU3
,
7AKV
,
2OAY
,
5DUQ
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P09871 C1S
3
C1S(16-688) [extracellular region]
(R-HSA-173557)
C1S C-terminal fragment [extracellular region]
(R-HSA-173608)
C1S N-terminal fragment [extracellular region]
(R-HSA-173607)
0.715
5
UniProt:O00187 MASP2
0.676
3
UniProt:O82882 STCE
0.618
3
UniProt:Q79GN7 Q79GN7
0.611
3
UniProt:O43889-2 CREB3
0.556
3
UniProt:P00736 C1R
3
C1R(18-705) [extracellular region]
(R-HSA-173554)
C1R N-terminal fragment [extracellular region]
(R-HSA-173606)
C1R C-terminal fragment [extracellular region]
(R-HSA-173603)
0.544
2
UniProt:Q5JTY5 ZNG1C
0.527
2
UniProt:Q8N6H7 ARFGAP2
1
ARFGAP2 [cytosol]
(R-HSA-6807738)
0.527
2
UniProt:P0C6X7-PRO_0000037310 REP
0.508
2
UniProt:P0C6X7-PRO_0000037320 REP
0.508
2
UniProt:P00750 PLAT
3
PLAT(311-562) [extracellular region]
(R-HSA-158762)
PLAT(36-310) [extracellular region]
(R-HSA-158758)
PLAT(36-562) [extracellular region]
(R-HSA-158754)
0.499
2
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