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C1S C-terminal fragment [extracellular region]
Stable Identifier
R-HSA-173608
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
C1S(427-688)
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Initial triggering of complement (Homo sapiens)
Conversion of C2 into C2a and C2b (Homo sapiens)
C4 activators [plasma membrane] (Homo sapiens)
Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Homo sapiens)
C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
Activated C1S [extracellular region] (Homo sapiens)
C1S C-terminal fragment [extracellular region] (Homo sapiens)
Conversion of C4 into C4a and C4b (Homo sapiens)
C4 activators [plasma membrane] (Homo sapiens)
Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Homo sapiens)
C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
Activated C1S [extracellular region] (Homo sapiens)
C1S C-terminal fragment [extracellular region] (Homo sapiens)
Creation of C4 and C2 activators (Homo sapiens)
Classical antibody-mediated complement activation (Homo sapiens)
Activation of C1s (Homo sapiens)
Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Homo sapiens)
C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
Activated C1S [extracellular region] (Homo sapiens)
C1S C-terminal fragment [extracellular region] (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Homo sapiens)
Activated C1S:SERPING1 [extracellular region] (Homo sapiens)
Activated C1S [extracellular region] (Homo sapiens)
C1S C-terminal fragment [extracellular region] (Homo sapiens)
Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 [extracellular region] (Homo sapiens)
2x Activated C1R:SERPING1:2x Activated C1S:SERPING1 [extracellular region] (Homo sapiens)
Activated C1S:SERPING1 [extracellular region] (Homo sapiens)
Activated C1S [extracellular region] (Homo sapiens)
C1S C-terminal fragment [extracellular region] (Homo sapiens)
C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Homo sapiens)
Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Homo sapiens)
C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
Activated C1S [extracellular region] (Homo sapiens)
C1S C-terminal fragment [extracellular region] (Homo sapiens)
Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane] (Homo sapiens)
Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Homo sapiens)
C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
Activated C1S [extracellular region] (Homo sapiens)
C1S C-terminal fragment [extracellular region] (Homo sapiens)
C1-Inh binds and inactivates C1r, C1s (Homo sapiens)
Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane] (Homo sapiens)
Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Homo sapiens)
C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
2x Activated C1R:2x Activated C1S [extracellular region] (Homo sapiens)
Activated C1S [extracellular region] (Homo sapiens)
C1S C-terminal fragment [extracellular region] (Homo sapiens)
Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 [extracellular region] (Homo sapiens)
2x Activated C1R:SERPING1:2x Activated C1S:SERPING1 [extracellular region] (Homo sapiens)
Activated C1S:SERPING1 [extracellular region] (Homo sapiens)
Activated C1S [extracellular region] (Homo sapiens)
C1S C-terminal fragment [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P09871 C1S
Gene Names
C1S
Chain
signal peptide:1-15, chain:16-688, chain:16-437, chain:438-688
Reference Genes
BioGPS Gene:716 C1S
COSMIC (genes):C1S C1S
CTD Gene:716 C1S
dbSNP Gene:716 C1S
ENSEMBL:ENSG00000182326 C1S
HGNC:1247 C1S
KEGG:hsa:716 C1S
Monarch:716 C1S
NCBI Gene:716 C1S
OMIM:120580 C1S
UCSC:P09871 C1S
Reference Transcript
RefSeq:NM_201442.3 C1S
RefSeq:NM_001734.4 C1S
RefSeq:XM_005253760.1 C1S
RefSeq:NM_001346850.1 C1S
Other Identifiers
11758100_s_at
11762882_at
11762883_x_at
1555229_PM_a_at
1555229_a_at
16747678
208747_PM_s_at
208747_s_at
3403165
3403167
3403172
3403179
3403180
3403182
3403183
3403184
3403185
3403186
3403187
3403188
3403189
3403190
3403191
3403192
3403193
3403194
3403195
3403196
3403197
3403198
3403199
3403200
3403201
3403202
3403203
3403204
3403205
3403206
3403207
3403208
3403209
3403210
3403211
3403212
40496_at
716
73511_at
7953603
A_14_P107079
A_23_P2492
A_33_P3230478
GE57497
GE84792
GE84848
GO:0002376
GO:0003824
GO:0004175
GO:0004252
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0006508
GO:0006956
GO:0006958
GO:0008236
GO:0016787
GO:0042802
GO:0045087
GO:0046872
GO:0072562
GO:0098542
GO:0140096
HMNXSV003006381
ILMN_1677603
ILMN_1781626
J04080_at
PH_hs_0026358
PH_hs_0038076
TC12003224.hg
g179647_3p_a_at
Participates
as a component of
Activated C1S [extracellular region] (Homo sapiens)
Other forms of this molecule
C1S N-terminal fragment [extracellular region]
C1S(16-688) [extracellular region]
Inferred To
C1S C-terminal fragment [extracellular region]
(Bos taurus)
C1S C-terminal fragment [extracellular region]
(Canis familiaris)
C1S C-terminal fragment [extracellular region]
(Gallus gallus)
C1S C-terminal fragment [extracellular region]
(Mus musculus)
C1S C-terminal fragment [extracellular region]
(Rattus norvegicus)
C1S C-terminal fragment [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_958850.1
,
NP_001333779.1
,
XP_005253817.1
,
NP_001725.1
ZINC - World Drugs
C1S_HUMAN
Guide to Pharmacology - Targets
2335
OpenTargets
ENSG00000182326
ENSEMBL
ENST00000406697
,
ENSP00000385035
,
ENSP00000328173
,
ENSP00000354057
,
ENST00000360817
,
ENST00000328916
ZINC - Substances
C1S_HUMAN
ZINC target
P09871
PRO
P09871
PDB
6F1H
,
4J1Y
,
4LOT
,
8GMN
,
4LOS
,
6F1C
,
4LOR
,
8TYP
,
4LMF
,
1ELV
,
1NZI
HPA
ENSG00000182326-C1S
Pharos - Targets
P09871
Orphanet
C1S
ZINC - Predictions - Purchasable
C1S_HUMAN
HMDB Protein
HMDBP07481
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05155 SERPING1
20
SERPING1 [platelet alpha granule lumen]
(R-HSA-139868)
SERPING1 L177P [endoplasmic reticulum lumen]
(R-HSA-9650574)
SERPING1 R400C [endoplasmic reticulum lumen]
(R-HSA-9650511)
SERPING1 V288E [endoplasmic reticulum lumen]
(R-HSA-9650415)
SERPING1 G184_P228del [endoplasmic reticulum lumen]
(R-HSA-9650472)
SERPING1 F236S [endoplasmic reticulum lumen]
(R-HSA-9650538)
SERPING1 T189N [endoplasmic reticulum lumen]
(R-HSA-9650346)
SERPING1 P476L [endoplasmic reticulum lumen]
(R-HSA-9650563)
SERPING1 G184R [endoplasmic reticulum lumen]
(R-HSA-9650424)
SERPING1 P489R [endoplasmic reticulum lumen]
(R-HSA-9650330)
SERPING1 S170P [endoplasmic reticulum lumen]
(R-HSA-9650362)
SERPING1 S280_P282del [endoplasmic reticulum lumen]
(R-HSA-9650522)
SERPING1 V473M [endoplasmic reticulum lumen]
(R-HSA-9650331)
SERPING1 N291H [endoplasmic reticulum lumen]
(R-HSA-9650545)
SERPING1 Q484* [endoplasmic reticulum lumen]
(R-HSA-9650410)
SERPING1 A2_M53del [endoplasmic reticulum lumen]
(R-HSA-9651435)
SERPING1 W482* [endoplasmic reticulum lumen]
(R-HSA-9650502)
SERPING1 Q338* [endoplasmic reticulum lumen]
(R-HSA-9651424)
SERPING1 I196N [endoplasmic reticulum lumen]
(R-HSA-9651390)
SERPING1 S36Ffs*21 [endoplasmic reticulum lumen]
(R-HSA-9651423)
0.715
5
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