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ARFGAP2 [cytosol]
Stable Identifier
R-HSA-6807738
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP2 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP2 [cytosol] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP2 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 binds effectors at the plasma membrane (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
ARFGAP2 [cytosol] (Homo sapiens)
CDC42:GTP:CDC42 effectors [plasma membrane] (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
ARFGAP2 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP2 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP2 [cytosol] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP2 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP2 [cytosol] (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Golgi-to-ER retrograde transport (Homo sapiens)
COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP2 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP2 [cytosol] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP2 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N6H7 ARFGAP2
Gene Names
ARFGAP2, ZNF289, Nbla10535
Chain
initiator methionine:, chain:2-521
Reference Genes
BioGPS Gene:84364 ARFGAP2
COSMIC (genes):ARFGAP2 ARFGAP2
CTD Gene:84364 ARFGAP2
dbSNP Gene:84364 ARFGAP2
ENSEMBL:ENSG00000149182 ARFGAP2
HGNC:13504 ARFGAP2
KEGG:hsa:84364 ARFGAP2
Monarch:84364 ARFGAP2
NCBI Gene:84364 ARFGAP2
OMIM:606908 ARFGAP2
UCSC:Q8N6H7 ARFGAP2
Reference Transcript
RefSeq:NM_001242832.1 ARFGAP2
RefSeq:NM_032389.4 ARFGAP2
Other Identifiers
11734038_a_at
11747963_a_at
11748218_a_at
11761097_at
16737890
211975_PM_at
211975_at
235734_PM_at
235734_at
3371929
3371930
3371931
3371932
3371933
3371934
3371935
3371936
3371937
3371938
3371940
3371941
3371942
3371943
3371944
3371945
3371946
3371947
3371948
3371949
3371950
3371951
3371952
3371953
3371954
3371955
3371956
3371957
3371958
3371959
3371960
3371961
3371962
3371963
39437_at
69566_at
7947784
84364
A_23_P161552
A_33_P3272483
A_33_P3358347
GE83414
GO:0000139
GO:0005096
GO:0005737
GO:0005794
GO:0005829
GO:0005886
GO:0008270
GO:0012505
GO:0015031
GO:0016020
GO:0016192
GO:0043226
GO:0046872
GO:0048205
GO:0098772
HMNXSV003024144
Hs.173281.0.A1_3p_at
Hs.256310.1.S1_3p_at
ILMN_1769250
PH_hs_0025485
PH_hs_0033384
TC11001730.hg
p2288
Participates
as a candidate of
CDC42 effectors [cytosol] (Homo sapiens)
as a member of
ARFGAP1,2,3 [cytosol] (Homo sapiens)
Inferred To
ARFGAP2 [cytosol]
(Bos taurus)
ARFGAP2 [cytosol]
(Caenorhabditis elegans)
ARFGAP2 [cytosol]
(Canis familiaris)
ARFGAP2 [cytosol]
(Dictyostelium discoideum)
ARFGAP2 [cytosol]
(Gallus gallus)
ARFGAP2 [cytosol]
(Plasmodium falciparum)
ARFGAP2 [cytosol]
(Schizosaccharomyces pombe)
ARFGAP2 [cytosol]
(Sus scrofa)
ArfGAP3 [cytosol]
(Drosophila melanogaster)
Homologues of ARFGAP2 [cytosol]
(Dictyostelium discoideum)
Homologues of ARFGAP2 [cytosol]
(Plasmodium falciparum)
Homologues of ARFGAP2 [cytosol]
(Saccharomyces cerevisiae)
Homologues of ARFGAP2 [cytosol]
(Schizosaccharomyces pombe)
GLO3 [cytosol]
(Saccharomyces cerevisiae)
arfgap2 [cytosol]
(Xenopus tropicalis)
glo3 [cytosol]
(Schizosaccharomyces pombe)
Arfgap2 [cytosol]
(Mus musculus)
Arfgap2 [cytosol]
(Rattus norvegicus)
GCS1 [cytosol]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_001229761.1
,
NP_115765.2
ENSEMBL
ENSG00000149182
,
ENSP00000434442
,
ENST00000524782
OpenTargets
ENSG00000149182
GeneCards
ARFGAP2
HPA
ENSG00000149182-ARFGAP2
PRO
Q8N6H7
Pharos - Targets
Q8N6H7
HMDB Protein
HMDBP08306
PDB
2P57
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05155 SERPING1
20
SERPING1 L177P [endoplasmic reticulum lumen]
(R-HSA-9650574)
SERPING1 R400C [endoplasmic reticulum lumen]
(R-HSA-9650511)
SERPING1 V288E [endoplasmic reticulum lumen]
(R-HSA-9650415)
SERPING1 G184_P228del [endoplasmic reticulum lumen]
(R-HSA-9650472)
SERPING1 F236S [endoplasmic reticulum lumen]
(R-HSA-9650538)
SERPING1 T189N [endoplasmic reticulum lumen]
(R-HSA-9650346)
SERPING1 P476L [endoplasmic reticulum lumen]
(R-HSA-9650563)
SERPING1 G184R [endoplasmic reticulum lumen]
(R-HSA-9650424)
SERPING1 P489R [endoplasmic reticulum lumen]
(R-HSA-9650330)
SERPING1 S170P [endoplasmic reticulum lumen]
(R-HSA-9650362)
SERPING1 S280_P282del [endoplasmic reticulum lumen]
(R-HSA-9650522)
SERPING1 V473M [endoplasmic reticulum lumen]
(R-HSA-9650331)
SERPING1 N291H [endoplasmic reticulum lumen]
(R-HSA-9650545)
SERPING1 Q484* [endoplasmic reticulum lumen]
(R-HSA-9650410)
SERPING1 A2_M53del [endoplasmic reticulum lumen]
(R-HSA-9651435)
SERPING1 W482* [endoplasmic reticulum lumen]
(R-HSA-9650502)
SERPING1 Q338* [endoplasmic reticulum lumen]
(R-HSA-9651424)
SERPING1 I196N [endoplasmic reticulum lumen]
(R-HSA-9651390)
SERPING1 S36Ffs*21 [endoplasmic reticulum lumen]
(R-HSA-9651423)
SERPING1 G184E [endoplasmic reticulum lumen]
(R-HSA-9650527)
0.527
2
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