Reactome | ARFGAP2 [cytosol]

ARFGAP2 [cytosol]

Stable Identifier

R-HSA-6807738

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
        
        ARFGAP1,2,3 [cytosol] (Homo sapiens)
        
        ARFGAP2 [cytosol] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        ARFGAP1,2,3 [cytosol] (Homo sapiens)
        
        ARFGAP2 [cytosol] (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        ARFGAP1,2,3 [cytosol] (Homo sapiens)
        
        ARFGAP2 [cytosol] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        ARFGAP1,2,3 [cytosol] (Homo sapiens)
        
        ARFGAP2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8N6H7 ARFGAP2

Gene Names

ARFGAP2, ZNF289, Nbla10535

Chain

initiator methionine:1, chain:2-521

Reference Genes

BioGPS Gene:84364 ARFGAP2

COSMIC (genes):ARFGAP2 ARFGAP2

CTD Gene:84364 ARFGAP2

dbSNP Gene:84364 ARFGAP2

ENSEMBL:ENSG00000149182 ARFGAP2

HGNC:13504 ARFGAP2

KEGG Gene (Homo sapiens):84364 ARFGAP2

Monarch:84364 ARFGAP2

NCBI Gene:84364 ARFGAP2

OMIM:606908 ARFGAP2

UCSC:Q8N6H7 ARFGAP2

Reference Transcript

Other Identifiers

0005360097

11734038_a_at

11747963_a_at

11748218_a_at

16737890

211975_at

3371929

3371930

3371932

3371933

3371934

3371936

3371937

3371940

3371941

3371942

3371945

3371950

3371951

3371956

3371957

3371959

3371960

3371962

39437_at

69566_at

7947784

84364

A_23_P161552

A_33_P3272483

GE83414

GO:0000139

GO:0003674

GO:0005096

GO:0005575

GO:0005622

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0006810

GO:0006888

GO:0006890

GO:0008150

GO:0015031

GO:0016020

GO:0016192

GO:0030234

GO:0043167

GO:0043226

GO:0043547

GO:0046872

GO:0048205

GO:0061024

HMNXSV003024144

Hs.256310.1.S1_3p_at

ILMN_1769250

PH_hs_0025485

PH_hs_0033384

TC11001730.hg

Participates

as a candidate of

CDC42 effectors [cytosol] (Homo sapiens)

as a member of

ARFGAP1,2,3 [cytosol] (Homo sapiens)

Inferred To

ARFGAP2 [cytosol] (Caenorhabditis elegans)

ARFGAP2 [cytosol] (Canis familiaris)

ARFGAP2 [cytosol] (Dictyostelium discoideum)

ARFGAP2 [cytosol] (Gallus gallus)

ARFGAP2 [cytosol] (Plasmodium falciparum)

ARFGAP2 [cytosol] (Sus scrofa)

ARFGAP2 [cytosol] (Xenopus tropicalis)

ArfGAP3 [cytosol] (Drosophila melanogaster)

Homologues of ARFGAP2 [cytosol] (Dictyostelium discoideum)

Homologues of ARFGAP2 [cytosol] (Plasmodium falciparum)

Homologues of ARFGAP2 [cytosol] (Saccharomyces cerevisiae)

GLO3 [cytosol] (Saccharomyces cerevisiae)

arfgap2 [cytosol] (Danio rerio)

glo3 [cytosol] (Schizosaccharomyces pombe)

Arfgap2 [cytosol] (Mus musculus)

Arfgap2 [cytosol] (Rattus norvegicus)

GCS1 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001229761.1, NP_115765.2

OpenTargets

ENSG00000149182

GeneCards

Q8N6H7

HPA

ENSG00000149182-ARFGAP2

Ensembl

ENSG00000149182, ENST00000524782, ENSP00000434442

PRO

Q8N6H7

Pharos - Targets

Q8N6H7

HMDB Protein

HMDBP08306

PDB

2P57