Reactome | ARFGAP2 [cytosol]

ARFGAP2 [cytosol]

Stable Identifier

R-HSA-6807738

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
        
        ARFGAP1,2,3 [cytosol] (Homo sapiens)
        
        ARFGAP2 [cytosol] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        ARFGAP1,2,3 [cytosol] (Homo sapiens)
        
        ARFGAP2 [cytosol] (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        ARFGAP1,2,3 [cytosol] (Homo sapiens)
        
        ARFGAP2 [cytosol] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        ARFGAP1,2,3 [cytosol] (Homo sapiens)
        
        ARFGAP2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8N6H7 ARFGAP2

Gene Names

ARFGAP2, ZNF289, Nbla10535

Chain

initiator methionine:, chain:2-521

Reference Genes

BioGPS Gene:84364 ARFGAP2

COSMIC (genes):ARFGAP2 ARFGAP2

CTD Gene:84364 ARFGAP2

dbSNP Gene:84364 ARFGAP2

ENSEMBL:ENSG00000149182 ARFGAP2

HGNC:13504 ARFGAP2

KEGG:hsa:84364 ARFGAP2

Monarch:84364 ARFGAP2

NCBI Gene:84364 ARFGAP2

OMIM:606908 ARFGAP2

UCSC:Q8N6H7 ARFGAP2

Reference Transcript

Other Identifiers

11734038_a_at

11747963_a_at

11748218_a_at

11761097_at

16737890

211975_PM_at

211975_at

235734_PM_at

235734_at

3371929

3371930

3371931

3371932

3371933

3371934

3371935

3371936

3371937

3371938

3371940

3371941

3371942

3371943

3371944

3371945

3371946

3371947

3371948

3371949

3371950

3371951

3371952

3371953

3371954

3371955

3371956

3371957

3371958

3371959

3371960

3371961

3371962

3371963

39437_at

69566_at

7947784

84364

A_23_P161552

A_33_P3272483

A_33_P3358347

GE83414

GO:0000139

GO:0005096

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0008270

GO:0012505

GO:0015031

GO:0016020

GO:0016192

GO:0043226

GO:0046872

GO:0048205

GO:0098772

HMNXSV003024144

Hs.173281.0.A1_3p_at

Hs.256310.1.S1_3p_at

ILMN_1769250

PH_hs_0025485

PH_hs_0033384

TC11001730.hg

p2288

Participates

as a candidate of

CDC42 effectors [cytosol] (Homo sapiens)

as a member of

ARFGAP1,2,3 [cytosol] (Homo sapiens)

Inferred To

ARFGAP2 [cytosol] (Bos taurus)

ARFGAP2 [cytosol] (Caenorhabditis elegans)

ARFGAP2 [cytosol] (Canis familiaris)

ARFGAP2 [cytosol] (Dictyostelium discoideum)

ARFGAP2 [cytosol] (Gallus gallus)

ARFGAP2 [cytosol] (Plasmodium falciparum)

ARFGAP2 [cytosol] (Schizosaccharomyces pombe)

ARFGAP2 [cytosol] (Sus scrofa)

ArfGAP3 [cytosol] (Drosophila melanogaster)

Homologues of ARFGAP2 [cytosol] (Dictyostelium discoideum)

Homologues of ARFGAP2 [cytosol] (Plasmodium falciparum)

Homologues of ARFGAP2 [cytosol] (Saccharomyces cerevisiae)

Homologues of ARFGAP2 [cytosol] (Schizosaccharomyces pombe)

GLO3 [cytosol] (Saccharomyces cerevisiae)

arfgap2 [cytosol] (Xenopus tropicalis)

glo3 [cytosol] (Schizosaccharomyces pombe)

Arfgap2 [cytosol] (Mus musculus)

Arfgap2 [cytosol] (Rattus norvegicus)

GCS1 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001229761.1, NP_115765.2

ENSEMBL

ENSG00000149182, ENSP00000434442, ENST00000524782

OpenTargets

ENSG00000149182

GeneCards

ARFGAP2

HPA

ENSG00000149182-ARFGAP2

PRO

Q8N6H7

Pharos - Targets

Q8N6H7

HMDB Protein

HMDBP08306

PDB

2P57

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05155 SERPING1	20	SERPING1 L177P [endoplasmic reticulum lumen] (R-HSA-9650574) SERPING1 R400C [endoplasmic reticulum lumen] (R-HSA-9650511) SERPING1 V288E [endoplasmic reticulum lumen] (R-HSA-9650415) SERPING1 G184_P228del [endoplasmic reticulum lumen] (R-HSA-9650472) SERPING1 F236S [endoplasmic reticulum lumen] (R-HSA-9650538) SERPING1 T189N [endoplasmic reticulum lumen] (R-HSA-9650346) SERPING1 P476L [endoplasmic reticulum lumen] (R-HSA-9650563) SERPING1 G184R [endoplasmic reticulum lumen] (R-HSA-9650424) SERPING1 P489R [endoplasmic reticulum lumen] (R-HSA-9650330) SERPING1 S170P [endoplasmic reticulum lumen] (R-HSA-9650362) SERPING1 S280_P282del [endoplasmic reticulum lumen] (R-HSA-9650522) SERPING1 V473M [endoplasmic reticulum lumen] (R-HSA-9650331) SERPING1 N291H [endoplasmic reticulum lumen] (R-HSA-9650545) SERPING1 Q484* [endoplasmic reticulum lumen] (R-HSA-9650410) SERPING1 A2_M53del [endoplasmic reticulum lumen] (R-HSA-9651435) SERPING1 W482* [endoplasmic reticulum lumen] (R-HSA-9650502) SERPING1 Q338* [endoplasmic reticulum lumen] (R-HSA-9651424) SERPING1 I196N [endoplasmic reticulum lumen] (R-HSA-9651390) SERPING1 S36Ffs*21 [endoplasmic reticulum lumen] (R-HSA-9651423) SERPING1 G184E [endoplasmic reticulum lumen] (R-HSA-9650527)	0.527	2