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NOS2 gene produces NOS2 protein
Stable Identifier
R-HSA-9636261
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
nucleoplasm
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Infection with Mycobacterium tuberculosis (Homo sapiens)
Response of Mtb to phagocytosis (Homo sapiens)
Suppression of phagosomal maturation (Homo sapiens)
Inhibition of nitric oxide production (Homo sapiens)
NOS2 gene produces NOS2 protein (Homo sapiens)
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The inducible nitric oxide synthase (NOS2) gene produces NOS2 protein. It is regulated by a NOS2 promotor, which itself is regulated by mycobacterial PPE family protein PPE2 (Bhat et al. 2017).
Literature References
PubMed ID
Title
Journal
Year
28071726
The PPE2 protein of Mycobacterium tuberculosis translocates to host nucleus and inhibits nitric oxide production
Ghosh, S
,
Mukhopadhyay, S
,
Kotturu, SK
,
Bhat, KH
,
Srivastava, S
Sci Rep
2017
Participants
Input
NOS2 gene [nucleoplasm]
(Homo sapiens)
Output
NOS2 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Inhibition of nitric oxide production (Homo sapiens)
This event is regulated
Negatively by
Regulator
PPE2:NOS2 gene [nucleoplasm]
(Homo sapiens)
Disease
Name
Identifier
Synonyms
tuberculosis
DOID:399
tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R (2019-02-06)
Reviewed
Wilkinson, RJ (2019-10-23)
Deffur, A (2019-10-23)
Created
Koile, I (2019-02-12)
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