NEIL3 resolves psoralen-induced ICLs

Stable Identifier
R-HSA-9635996
Type
Reaction [transition]
Species
Homo sapiens
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NEIL3 can resolve interstrand crosslinks (ICLs) in replicating DNA, induced by intercalating DNA damaging agent psoralen, which cross links thymine bases from two replicated double strand DNAs (dsDNAs). NEIL3-mediated cleavage of psoralen-induced ICLs results in one dsDNA molecule with an abasic site (AP site) and one dsDNA molecule with a thymine-psoralen adduct. NEIL3-mediated resolution of ICLs is independent of the Fanconia anemia (FA) pathway and was demonstrated for both Xenopus (Semlow et al. 2016) and human (Martin et al. 2017) NEIL3.

Literature References
PubMed ID Title Journal Year
29234069 The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure

Martin, PR, Couvé, S, Zutterling, C, Albelazi, MS, Groisman, R, Matkarimov, BT, Parsons, JL, Elder, RH, Saparbaev, MK

Sci Rep 2017
27693351 Replication-Dependent Unhooking of DNA Interstrand Cross-Links by the NEIL3 Glycosylase

Semlow, DR, Zhang, J, Budzowska, M, Drohat, AC, Walter, JC

Cell 2016
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Catalyst Activity
Title
DNA N-glycosylase activity of NEIL3 [nucleoplasm]
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