NEIL3 resolves psoralen-induced ICLs

Stable Identifier
Reaction [transition]
Homo sapiens
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NEIL3 can resolve interstrand crosslinks (ICLs) in replicating DNA, induced by intercalating DNA damaging agent psoralen, which cross links thymine bases from two replicated double strand DNAs (dsDNAs). NEIL3-mediated cleavage of psoralen-induced ICLs results in one dsDNA molecule with an abasic site (AP site) and one dsDNA molecule with a thymine-psoralen adduct. NEIL3-mediated resolution of ICLs is independent of the Fanconia anemia (FA) pathway and was demonstrated for both Xenopus (Semlow et al. 2016) and human (Martin et al. 2017) NEIL3.

Literature References
PubMed ID Title Journal Year
27693351 Replication-Dependent Unhooking of DNA Interstrand Cross-Links by the NEIL3 Glycosylase

Budzowska, M, Zhang, J, Semlow, DR, Drohat, AC, Walter, JC

Cell 2016
29234069 The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure

Saparbaev, MK, Groisman, R, Couvé, S, Zutterling, C, Parsons, JL, Matkarimov, BT, Martin, PR, Elder, RH, Albelazi, MS

Sci Rep 2017
Catalyst Activity

DNA N-glycosylase activity of NEIL3 [nucleoplasm]

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