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AP-dsDNA [nucleoplasm]
Stable Identifier
R-HSA-110187
Type
Genes and Transcripts [GenomeEncodedEntity]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA containing an apurinic/apyrimidinic (AP) site
Locations in the PathwayBrowser
for Species:
Homo sapiens
Gallus gallus
Expand all
DNA replication and repair (Gallus gallus)
DNA repair (Gallus gallus)
Base Excision Repair (Gallus gallus)
Resolution of Abasic Sites (AP sites) (Gallus gallus)
Displacement of DNA glycosylase and endonucleolytic cleavage by DNA-lyase (Gallus gallus)
AP-dsDNA [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Base-Excision Repair, AP Site Formation (Homo sapiens)
Depurination (Homo sapiens)
Cleavage of the damaged purine (Homo sapiens)
Cleavage of 3-methyladenine by MPG glycosylase (Homo sapiens)
MPG:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Homo sapiens)
MUTYH:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Cleavage of ethenoadenine by MPG glycosylase (Homo sapiens)
MPG:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Cleavage of hypoxanthine by MPG glycosylase (Homo sapiens)
MPG:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Excision of 8-oxoguanine by OGG1 glycosylase (Homo sapiens)
OGG1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL3 cleaves 5-guanidinohydantoin (Homo sapiens)
NEIL3:AP-DNA [nucleoplasm] (Homo sapiens)
AP-DNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL3 cleaves spiroiminodihydantoin (Homo sapiens)
NEIL3:AP-DNA [nucleoplasm] (Homo sapiens)
AP-DNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Depyrimidination (Homo sapiens)
Cleavage of the damaged pyrimidine (Homo sapiens)
Cleavage of 5-hydroxyluracil by UNG glycosylase (Homo sapiens)
UNG-1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Cleavage of cytosine glycol by NTHL1 glycosylase (Homo sapiens)
NTHL1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Cleavage of dihydrouracil by NTHL1 glycosylase (Homo sapiens)
NTHL1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Cleavage of ethenocytosine by TDG glycosylase (Homo sapiens)
TDG:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase (Homo sapiens)
NTHL1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Cleavage of thymine by MBD4 glycosylase (Homo sapiens)
MBD4:CpG(AP)-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Cleavage of thymine by TDG glycosylase (Homo sapiens)
TDG:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Cleavage of thymine glycol by NTHL1 glycosylase (Homo sapiens)
NTHL1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Cleavage of uracil by MBD4 glycosylase (Homo sapiens)
MBD4:CpG(AP)-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Cleavage of uracil by SMUG1 glycosylase (Homo sapiens)
SMUG1:AP-DNA [nucleoplasm] (Homo sapiens)
AP-DNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Cleavage of uracil by TDG glycosylase (Homo sapiens)
TDG:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Cleavage of uracil by UNG glycosylase (Homo sapiens)
UNG-1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Excision of FapyG by OGG1 glycosylase (Homo sapiens)
OGG1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1 cleaves DHU from damaged DNA (Homo sapiens)
NEIL1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1 cleaves FapyA from damaged DNA (Homo sapiens)
NEIL1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1 cleaves FapyG from damaged DNA (Homo sapiens)
NEIL1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1 cleaves thymine glycol from damaged DNA (Homo sapiens)
NEIL1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL2 cleaves 5-OHU from damaged DNA (Homo sapiens)
NEIL2:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL3 cleaves thymine glycol (Homo sapiens)
NEIL3:AP-DNA [nucleoplasm] (Homo sapiens)
AP-DNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL3-mediated resolution of ICLs (Homo sapiens)
NEIL3 resolves abasic site-induced ICLs (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL3 resolves psoralen-induced ICLs (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Homo sapiens)
APEX1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Homo sapiens)
NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Homo sapiens)
NEIL1,NEIL2:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
OGG1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2 incises DNA strand 5' to the AP site (Homo sapiens)
NEIL1,NEIL2:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Displacement of DNA glycosylase by APEX1 (Homo sapiens)
Displacement of MBD4 glycosylase by APEX1 at the AP site (Homo sapiens)
APEX1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
MBD4:CpG(AP)-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Displacement of MPG glycosylase by APEX1 at the AP site (Homo sapiens)
APEX1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
MPG:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Displacement of MUTYH glycosylase by APEX1 at the AP site (Homo sapiens)
APEX1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
MUTYH:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Homo sapiens)
APEX1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
NTHL1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Displacement of OGG1 glycosylase by APEX1 at the AP site (Homo sapiens)
APEX1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
OGG1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Displacement of SMUG1 glycosylase by APEX1 at the AP site (Homo sapiens)
APEX1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
SMUG1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Displacement of TDG glycosylase by APEX1 at the AP site (Homo sapiens)
APEX1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
TDG:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Displacement of UNG glycosylase by APEX1 at the AP site (Homo sapiens)
APEX1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
UNG-1:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
DNA Damage Bypass (Homo sapiens)
Recognition of DNA damage by PCNA-containing replication complex (Homo sapiens)
Damaged dsDNA becomes damaged DNA template (Homo sapiens)
Damaged dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Homo sapiens)
Termination of translesion DNA synthesis (Homo sapiens)
POLD,POLE complete replication of damaged DNA after TLS (Homo sapiens)
Damaged dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
TET1,2,3 and TDG demethylate DNA (Homo sapiens)
TDG excises 5-carboxylcytosine (Homo sapiens)
TDG:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
TDG excises 5-formylcytosine (Homo sapiens)
TDG:AP-dsDNA [nucleoplasm] (Homo sapiens)
AP-dsDNA [nucleoplasm] (Homo sapiens)
Participates
as an input of
Displacement of DNA glycosylase and endonucleolytic cleavage by DNA-lyase (Gallus gallus)
as a member of
Damaged dsDNA [nucleoplasm] (Homo sapiens)
AP-DNA [nucleoplasm] (Homo sapiens)
as a component of
Mutyh:AP-dsDNA [nucleoplasm] (Mus musculus)
SMUG1:AP-dsDNA [nucleoplasm] (Homo sapiens)
APEX1:AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1,NEIL2:AP-dsDNA [nucleoplasm] (Homo sapiens)
MBD4:CpG(AP)-dsDNA [nucleoplasm] (Homo sapiens)
NTHL1:AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL1:AP-dsDNA [nucleoplasm] (Homo sapiens)
TDG:AP-dsDNA [nucleoplasm] (Homo sapiens)
NEIL2:AP-dsDNA [nucleoplasm] (Homo sapiens)
UNG-1:AP-dsDNA [nucleoplasm] (Homo sapiens)
MPG:AP-dsDNA [nucleoplasm] (Homo sapiens)
MUTYH:AP-dsDNA [nucleoplasm] (Homo sapiens)
OGG1:AP-dsDNA [nucleoplasm] (Homo sapiens)
as an output of
NEIL3 resolves psoralen-induced ICLs (Homo sapiens)
NEIL3 resolves abasic site-induced ICLs (Homo sapiens)
Inferred To
Ghost homologue of AP-dsDNA [nucleoplasm]
(Bos taurus)
Ghost homologue of AP-dsDNA [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of AP-dsDNA [nucleoplasm]
(Canis familiaris)
Ghost homologue of AP-dsDNA [nucleoplasm]
(Danio rerio)
Ghost homologue of AP-dsDNA [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of AP-dsDNA [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of AP-dsDNA [nucleoplasm]
(Gallus gallus)
Ghost homologue of AP-dsDNA [nucleoplasm]
(Mus musculus)
Ghost homologue of AP-dsDNA [nucleoplasm]
(Plasmodium falciparum)
Ghost homologue of AP-dsDNA [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of AP-dsDNA [nucleoplasm]
(Saccharomyces cerevisiae)
Ghost homologue of AP-dsDNA [nucleoplasm]
(Schizosaccharomyces pombe)
Ghost homologue of AP-dsDNA [nucleoplasm]
(Sus scrofa)
Ghost homologue of AP-dsDNA [nucleoplasm]
(Xenopus tropicalis)
Cross References
ChEBI
16991
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