NEIL3-mediated resolution of ICLs

Stable Identifier
R-HSA-9636003
Type
Pathway
Species
Homo sapiens
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DNA glycosylase activity of NEIL3 is involved in resolution (unhooking) of psolaren-induced interstrand crosslinks (ICLs), as well as abasic site-induced ICLs (AP-ICLs) in a Fanconia anemia (FA) pathway-independent fashion (Semlow et al. 2016, Martin et al. 2017).

Literature References
PubMed ID Title Journal Year
29234069 The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure

Martin, PR, Couvé, S, Zutterling, C, Albelazi, MS, Groisman, R, Matkarimov, BT, Parsons, JL, Elder, RH, Saparbaev, MK

Sci Rep 2017
27693351 Replication-Dependent Unhooking of DNA Interstrand Cross-Links by the NEIL3 Glycosylase

Semlow, DR, Zhang, J, Budzowska, M, Drohat, AC, Walter, JC

Cell 2016
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