NEIL3-mediated resolution of ICLs

Stable Identifier
R-HSA-9636003
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NEIL3-mediated resolution of ICLs
Click the image above or here to open this pathway in the Pathway Browser
DNA glycosylase activity of NEIL3 is involved in resolution (unhooking) of psolaren-induced interstrand crosslinks (ICLs), as well as abasic site-induced ICLs (AP-ICLs) in a Fanconia anemia (FA) pathway-independent fashion (Semlow et al. 2016, Martin et al. 2017).
Literature References
PubMed ID Title Journal Year
27693351 Replication-Dependent Unhooking of DNA Interstrand Cross-Links by the NEIL3 Glycosylase

Budzowska, M, Zhang, J, Semlow, DR, Drohat, AC, Walter, JC

Cell 2016
29234069 The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure

Saparbaev, MK, Groisman, R, Couvé, S, Zutterling, C, Parsons, JL, Matkarimov, BT, Martin, PR, Elder, RH, Albelazi, MS

Sci Rep 2017
Participants
Events
Participates
as an event of
Reviewed
Zhou, J  (2019-02-11)
Created
Orlic-Milacic, M  (2019-02-12)
Cite Us!